Tim Holm Jakobsen

Tim Holm Jakobsen

Associate Professor

ORCID: 0000-0002-1671-2155

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  1. Published

    Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

    Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Solid-phase synthesis and biological evaluation of N-dipeptido L-homoserine lactones as quorum sensing activators

    Hansen, M. R., Le Quement, S. T., Jakobsen, Tim Holm, Skovstrup, S., Taboureau, O., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T. E., 10 Feb 2014, In: ChemBioChem. 15, 3, p. 460-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Quorum sensing regulation in Aeromonas hydrophila

    Garde, C., Bjarnsholt, Thomas, Givskov, Michael, Jakobsen, Tim Holm, Hentzer, M., Claussen, A., Sneppen, K., Ferkinghoff-Borg, J. & Sams, T., 2010, In: Journal of Molecular Biology. 396, 4, p. 849-57 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

    Fong, J., Yuan, M., Jakobsen, Tim Holm, Mortensen, K. T., Delos Santos, M. M. S., Chua, S. L., Yang, L., Tan, C. H., Nielsen, Thomas Eiland & Givskov, Michael, 12 Jan 2017, In: Journal of Medicinal Chemistry. 60, 1, p. 215-227

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors

    Flagstad, T., Pedersen, M. T., Jakobsen, Tim Holm, Felding, J., Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, K. & Nielsen, Thomas Eiland, 2022, In: Bioorganic and Medicinal Chemistry Letters. 57, 128499.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR

    Claussen, A., Jakobsen, Tim Holm, Bjarnsholt, Thomas, Givskov, Michael, Welch, M., Ferkinghoff-Borg, J. & Sams, T., 2013, In: International Journal of Molecular Sciences (Online). 14, 7, p. 13360-76 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Imaging N-acyl homoserine lactone quorum sensing in vivo

    Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Givskov, Michael & Bjarnsholt, Thomas, 1 Jan 2011, In: Methods in Molecular Biology. 692, 2, p. 147-157 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

    Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    In vitro screens for quorum sensing inhibitors and in vivo confirmation of their effect

    Bjarnsholt, Thomas, van Gennip, M., Jakobsen, Tim Holm, Hultqvist, Louise Dahl, Jensen, Peter Østrup & Givskov, Michael, 2010, In: Nature Protocols (Print Edition). 5, 2, p. 282-93 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Process for the manufacture of ajoene derivatives

    Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

    Research output: Patent

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