Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

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Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
Original languageEnglish
JournalThe Journal of antimicrobial chemotherapy
Issue number5
Pages (from-to)1198-206
Number of pages9
Publication statusPublished - May 2012

    Research areas

  • Animals, Anti-Bacterial Agents, Bacterial Load, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Female, Foreign Bodies, Histocytochemistry, Mice, Mice, Inbred BALB C, Peritonitis, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing, Tobramycin

ID: 105877773