Standard
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. / Christensen, Louise; van Gennip, Maria; Jakobsen, Tim H; Alhede, Morten; Hougen, Hans Petter; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Maria.
In:
The Journal of antimicrobial chemotherapy, Vol. 67, No. 5, 05.2012, p. 1198-206.
Research output: Contribution to journal › Journal article › peer-review
Harvard
Christensen, L, van Gennip, M
, Jakobsen, TH, Alhede, M, Hougen, HP
, Høiby, N, Bjarnsholt, T, Givskov, M & Alhede, M 2012, '
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model',
The Journal of antimicrobial chemotherapy, vol. 67, no. 5, pp. 1198-206.
https://doi.org/10.1093/jac/dks002
APA
Christensen, L., van Gennip, M.
, Jakobsen, T. H., Alhede, M., Hougen, H. P.
, Høiby, N., Bjarnsholt, T., Givskov, M., & Alhede, M. (2012).
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
The Journal of antimicrobial chemotherapy,
67(5), 1198-206.
https://doi.org/10.1093/jac/dks002
Vancouver
Christensen L, van Gennip M
, Jakobsen TH, Alhede M, Hougen HP
, Høiby N et al.
Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.
The Journal of antimicrobial chemotherapy. 2012 May;67(5):1198-206.
https://doi.org/10.1093/jac/dks002
Author
Christensen, Louise ; van Gennip, Maria ; Jakobsen, Tim H ; Alhede, Morten ; Hougen, Hans Petter ; Høiby, Niels ; Bjarnsholt, Thomas ; Givskov, Michael ; Alhede, Maria. / Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. In: The Journal of antimicrobial chemotherapy. 2012 ; Vol. 67, No. 5. pp. 1198-206.
Bibtex
@article{e9e958bffc104c479ee2f93652d0302c,
title = "Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model",
abstract = "Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.",
keywords = "Animals, Anti-Bacterial Agents, Bacterial Load, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Female, Foreign Bodies, Histocytochemistry, Mice, Mice, Inbred BALB C, Peritonitis, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing, Tobramycin",
author = "Louise Christensen and {van Gennip}, Maria and Jakobsen, {Tim H} and Morten Alhede and Hougen, {Hans Petter} and Niels H{\o}iby and Thomas Bjarnsholt and Michael Givskov and Maria Alhede",
year = "2012",
month = may,
doi = "10.1093/jac/dks002",
language = "English",
volume = "67",
pages = "1198--206",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "5",
}
RIS
TY - JOUR
T1 - Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model
AU - Christensen, Louise
AU - van Gennip, Maria
AU - Jakobsen, Tim H
AU - Alhede, Morten
AU - Hougen, Hans Petter
AU - Høiby, Niels
AU - Bjarnsholt, Thomas
AU - Givskov, Michael
AU - Alhede, Maria
PY - 2012/5
Y1 - 2012/5
N2 - Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
AB - Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.
KW - Animals
KW - Anti-Bacterial Agents
KW - Bacterial Load
KW - Disease Models, Animal
KW - Drug Synergism
KW - Drug Therapy, Combination
KW - Female
KW - Foreign Bodies
KW - Histocytochemistry
KW - Mice
KW - Mice, Inbred BALB C
KW - Peritonitis
KW - Pseudomonas Infections
KW - Pseudomonas aeruginosa
KW - Quorum Sensing
KW - Tobramycin
U2 - 10.1093/jac/dks002
DO - 10.1093/jac/dks002
M3 - Journal article
C2 - 22302561
VL - 67
SP - 1198
EP - 1206
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 5
ER -