Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

Research output: Contribution to journalJournal articlepeer-review

Standard

Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. / Christensen, Louise; van Gennip, Maria; Jakobsen, Tim H; Alhede, Morten; Hougen, Hans Petter; Høiby, Niels; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Maria.

In: The Journal of antimicrobial chemotherapy, Vol. 67, No. 5, 05.2012, p. 1198-206.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Christensen, L, van Gennip, M, Jakobsen, TH, Alhede, M, Hougen, HP, Høiby, N, Bjarnsholt, T, Givskov, M & Alhede, M 2012, 'Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model', The Journal of antimicrobial chemotherapy, vol. 67, no. 5, pp. 1198-206. https://doi.org/10.1093/jac/dks002

APA

Christensen, L., van Gennip, M., Jakobsen, T. H., Alhede, M., Hougen, H. P., Høiby, N., Bjarnsholt, T., Givskov, M., & Alhede, M. (2012). Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. The Journal of antimicrobial chemotherapy, 67(5), 1198-206. https://doi.org/10.1093/jac/dks002

Vancouver

Christensen L, van Gennip M, Jakobsen TH, Alhede M, Hougen HP, Høiby N et al. Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. The Journal of antimicrobial chemotherapy. 2012 May;67(5):1198-206. https://doi.org/10.1093/jac/dks002

Author

Christensen, Louise ; van Gennip, Maria ; Jakobsen, Tim H ; Alhede, Morten ; Hougen, Hans Petter ; Høiby, Niels ; Bjarnsholt, Thomas ; Givskov, Michael ; Alhede, Maria. / Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model. In: The Journal of antimicrobial chemotherapy. 2012 ; Vol. 67, No. 5. pp. 1198-206.

Bibtex

@article{e9e958bffc104c479ee2f93652d0302c,
title = "Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model",
abstract = "Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.",
keywords = "Animals, Anti-Bacterial Agents, Bacterial Load, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Female, Foreign Bodies, Histocytochemistry, Mice, Mice, Inbred BALB C, Peritonitis, Pseudomonas Infections, Pseudomonas aeruginosa, Quorum Sensing, Tobramycin",
author = "Louise Christensen and {van Gennip}, Maria and Jakobsen, {Tim H} and Morten Alhede and Hougen, {Hans Petter} and Niels H{\o}iby and Thomas Bjarnsholt and Michael Givskov and Maria Alhede",
year = "2012",
month = may,
doi = "10.1093/jac/dks002",
language = "English",
volume = "67",
pages = "1198--206",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

AU - Christensen, Louise

AU - van Gennip, Maria

AU - Jakobsen, Tim H

AU - Alhede, Morten

AU - Hougen, Hans Petter

AU - Høiby, Niels

AU - Bjarnsholt, Thomas

AU - Givskov, Michael

AU - Alhede, Maria

PY - 2012/5

Y1 - 2012/5

N2 - Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.

AB - Quorum sensing (QS)-deficient Pseudomonas aeruginosa biofilms formed in vitro are more susceptible to tobramycin than QS-proficient P. aeruginosa biofilms, and combination treatment with a QS inhibitor (QSI) and tobramycin shows synergistic effects on the killing of in vitro biofilms. We extended these results to an in vivo P. aeruginosa foreign-body biofilm model. The effect of treatment initiated prophylactically was compared with treatment initiated 11 days post-insertion.

KW - Animals

KW - Anti-Bacterial Agents

KW - Bacterial Load

KW - Disease Models, Animal

KW - Drug Synergism

KW - Drug Therapy, Combination

KW - Female

KW - Foreign Bodies

KW - Histocytochemistry

KW - Mice

KW - Mice, Inbred BALB C

KW - Peritonitis

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Quorum Sensing

KW - Tobramycin

U2 - 10.1093/jac/dks002

DO - 10.1093/jac/dks002

M3 - Journal article

C2 - 22302561

VL - 67

SP - 1198

EP - 1206

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 5

ER -

ID: 105877773