A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

Research output: Contribution to journal › Journal article › Research › peer-review

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A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors. / Bang, Claus G.; Jensen, Jakob F.; O'Hanlon Cohrt, Emil; Olsen, Lasse B.; Siyum, Saba G.; Mortensen, Kim T.; Skovgaard, Tine; Berthelsen, Jens; Yang, Liang; Givskov, Michael; Qvortrup, Katrine; Nielsen, Thomas E.

In: ACS Combinatorial Science, Vol. 19, No. 10, 10.2017, p. 657-669.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bang, CG, Jensen, JF, O'Hanlon Cohrt, E, Olsen, LB, Siyum, SG, Mortensen, KT, Skovgaard, T, Berthelsen, J, Yang, L, Givskov, M, Qvortrup, K & Nielsen, TE 2017, 'A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors', ACS Combinatorial Science, vol. 19, no. 10, pp. 657-669. https://doi.org/10.1021/acscombsci.7b00068

APA

Bang, C. G., Jensen, J. F., O'Hanlon Cohrt, E., Olsen, L. B., Siyum, S. G., Mortensen, K. T., Skovgaard, T., Berthelsen, J., Yang, L., Givskov, M., Qvortrup, K., & Nielsen, T. E. (2017). A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors. ACS Combinatorial Science, 19(10), 657-669. https://doi.org/10.1021/acscombsci.7b00068

Vancouver

Bang CG, Jensen JF, O'Hanlon Cohrt E, Olsen LB, Siyum SG, Mortensen KT et al. A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors. ACS Combinatorial Science. 2017 Oct;19(10):657-669. https://doi.org/10.1021/acscombsci.7b00068

Author

Bang, Claus G. ; Jensen, Jakob F. ; O'Hanlon Cohrt, Emil ; Olsen, Lasse B. ; Siyum, Saba G. ; Mortensen, Kim T. ; Skovgaard, Tine ; Berthelsen, Jens ; Yang, Liang ; Givskov, Michael ; Qvortrup, Katrine ; Nielsen, Thomas E. / A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors. In: ACS Combinatorial Science. 2017 ; Vol. 19, No. 10. pp. 657-669.

Bibtex

@article{0bb1121eb07c435fab21fc87348560f9,
title = "A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors",
abstract = "We herein present broadly useful, readily available and nonintegral hydroxylamine linkers for the routine solid-phase synthesis of hydroxamic acids. The developed protocols enable the efficient synthesis and release of a wide range of hydroxamic acids from various resins, relying on high control and flexibility with respect to reagents and synthetic processes. A trityl-based hydroxylamine linker was used to synthesize a library of peptide hydroxamic acids. The inhibitory effects of the compounds were examined for seven HDAC enzyme subtypes using a chemiluminescence-based assay.",
keywords = "HDAC inhibitor, hydroxamic acid, linker, solid-phase synthesis",
author = "Bang, {Claus G.} and Jensen, {Jakob F.} and {O'Hanlon Cohrt}, Emil and Olsen, {Lasse B.} and Siyum, {Saba G.} and Mortensen, {Kim T.} and Tine Skovgaard and Jens Berthelsen and Liang Yang and Michael Givskov and Katrine Qvortrup and Nielsen, {Thomas E.}",
year = "2017",
month = oct,
doi = "10.1021/acscombsci.7b00068",
language = "English",
volume = "19",
pages = "657--669",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "ACS Publications",
number = "10",

}

RIS

TY - JOUR

T1 - A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors

AU - Bang, Claus G.

AU - Jensen, Jakob F.

AU - O'Hanlon Cohrt, Emil

AU - Olsen, Lasse B.

AU - Siyum, Saba G.

AU - Mortensen, Kim T.

AU - Skovgaard, Tine

AU - Berthelsen, Jens

AU - Yang, Liang

AU - Givskov, Michael

AU - Qvortrup, Katrine

AU - Nielsen, Thomas E.

PY - 2017/10

Y1 - 2017/10

N2 - We herein present broadly useful, readily available and nonintegral hydroxylamine linkers for the routine solid-phase synthesis of hydroxamic acids. The developed protocols enable the efficient synthesis and release of a wide range of hydroxamic acids from various resins, relying on high control and flexibility with respect to reagents and synthetic processes. A trityl-based hydroxylamine linker was used to synthesize a library of peptide hydroxamic acids. The inhibitory effects of the compounds were examined for seven HDAC enzyme subtypes using a chemiluminescence-based assay.

AB - We herein present broadly useful, readily available and nonintegral hydroxylamine linkers for the routine solid-phase synthesis of hydroxamic acids. The developed protocols enable the efficient synthesis and release of a wide range of hydroxamic acids from various resins, relying on high control and flexibility with respect to reagents and synthetic processes. A trityl-based hydroxylamine linker was used to synthesize a library of peptide hydroxamic acids. The inhibitory effects of the compounds were examined for seven HDAC enzyme subtypes using a chemiluminescence-based assay.

KW - HDAC inhibitor

KW - hydroxamic acid

KW - linker

KW - solid-phase synthesis

U2 - 10.1021/acscombsci.7b00068

DO - 10.1021/acscombsci.7b00068

M3 - Journal article

C2 - 28746804

AN - SCOPUS:85030788051

VL - 19

SP - 657

EP - 669

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

SN - 2156-8952

IS - 10

ER -

ID: 185035650