A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.

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A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli. / Tolker-Nielsen, Tim; Boe, Lars.

In: Journal of Bacteriology, Vol. 176, No. 14, 1994, p. 4306-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tolker-Nielsen, T & Boe, L 1994, 'A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.', Journal of Bacteriology, vol. 176, no. 14, pp. 4306-10.

APA

Tolker-Nielsen, T., & Boe, L. (1994). A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli. Journal of Bacteriology, 176(14), 4306-10.

Vancouver

Tolker-Nielsen T, Boe L. A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli. Journal of Bacteriology. 1994;176(14):4306-10.

Author

Tolker-Nielsen, Tim ; Boe, Lars. / A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli. In: Journal of Bacteriology. 1994 ; Vol. 176, No. 14. pp. 4306-10.

Bibtex

@article{84baf8c0bd4211dd8e02000ea68e967b,
title = "A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.",
abstract = "By methods analogous to those used in the classical statistical analysis of bacterial mutation, we have analyzed the formation of plasmid-free cells in populations of Escherichia coli harboring pBR322-derived plasmids. Application of fluctuation tests and papilla analysis suggested that there is a high variance in the probability that a plasmid-containing cell will produce a plasmid-free daughter cell. Apparently a subpopulation of plasmid-containing cells gives rise to progeny that produces plasmid-free cells with a high and unpredictable rate. This finding raises the question of whether plasmid maintenance can be adequately described by the conventional mathematical models.",
author = "Tim Tolker-Nielsen and Lars Boe",
note = "Keywords: Colony Count, Microbial; Culture Media; Escherichia coli; Models, Biological; Models, Statistical; Plasmids",
year = "1994",
language = "English",
volume = "176",
pages = "4306--10",
journal = "Journal of Bacteriology",
issn = "0021-9193",
publisher = "American Society for Microbiology",
number = "14",

}

RIS

TY - JOUR

T1 - A statistical analysis of the formation of plasmid-free cells in populations of Escherichia coli.

AU - Tolker-Nielsen, Tim

AU - Boe, Lars

N1 - Keywords: Colony Count, Microbial; Culture Media; Escherichia coli; Models, Biological; Models, Statistical; Plasmids

PY - 1994

Y1 - 1994

N2 - By methods analogous to those used in the classical statistical analysis of bacterial mutation, we have analyzed the formation of plasmid-free cells in populations of Escherichia coli harboring pBR322-derived plasmids. Application of fluctuation tests and papilla analysis suggested that there is a high variance in the probability that a plasmid-containing cell will produce a plasmid-free daughter cell. Apparently a subpopulation of plasmid-containing cells gives rise to progeny that produces plasmid-free cells with a high and unpredictable rate. This finding raises the question of whether plasmid maintenance can be adequately described by the conventional mathematical models.

AB - By methods analogous to those used in the classical statistical analysis of bacterial mutation, we have analyzed the formation of plasmid-free cells in populations of Escherichia coli harboring pBR322-derived plasmids. Application of fluctuation tests and papilla analysis suggested that there is a high variance in the probability that a plasmid-containing cell will produce a plasmid-free daughter cell. Apparently a subpopulation of plasmid-containing cells gives rise to progeny that produces plasmid-free cells with a high and unpredictable rate. This finding raises the question of whether plasmid maintenance can be adequately described by the conventional mathematical models.

M3 - Journal article

C2 - 8021216

VL - 176

SP - 4306

EP - 4310

JO - Journal of Bacteriology

JF - Journal of Bacteriology

SN - 0021-9193

IS - 14

ER -

ID: 8780635