An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal

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An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal. / Harmsen, Morten; Yang, Liang; Pamp, Sünje J; Tolker-Nielsen, Tim.

In: FEMS Immunology and Medical Microbiology, Vol. 59, No. 3, 2010, p. 253-68.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Harmsen, M, Yang, L, Pamp, SJ & Tolker-Nielsen, T 2010, 'An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal', FEMS Immunology and Medical Microbiology, vol. 59, no. 3, pp. 253-68. https://doi.org/10.1111/j.1574-695X.2010.00690.x

APA

Harmsen, M., Yang, L., Pamp, S. J., & Tolker-Nielsen, T. (2010). An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal. FEMS Immunology and Medical Microbiology, 59(3), 253-68. https://doi.org/10.1111/j.1574-695X.2010.00690.x

Vancouver

Harmsen M, Yang L, Pamp SJ, Tolker-Nielsen T. An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal. FEMS Immunology and Medical Microbiology. 2010;59(3):253-68. https://doi.org/10.1111/j.1574-695X.2010.00690.x

Author

Harmsen, Morten ; Yang, Liang ; Pamp, Sünje J ; Tolker-Nielsen, Tim. / An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal. In: FEMS Immunology and Medical Microbiology. 2010 ; Vol. 59, No. 3. pp. 253-68.

Bibtex

@article{64e253b0d12a11df825b000ea68e967b,
title = "An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal",
abstract = "We review the recent advances in the understanding of the Pseudomonas aeruginosa biofilm lifestyle from studies using in vitro laboratory setups such as flow chambers and microtiter trays. Recent work sheds light on the role of nutrients, motility, and quorum sensing in structure formation in P. aeruginosa biofilms. The second messenger, c-di-GMP, is established as an important regulator of the synthesis of polysaccharide and protein components of the biofilm matrix. Extracellular DNA is shown to be an essential component of the biofilm matrix. It has become apparent that biofilm formation involves interactions between different subpopulations. The molecular mechanisms underlying the tolerance of biofilm bacteria to antimicrobial agents are beginning to be unraveled, and new knowledge has been obtained regarding the environmental cues and regulatory mechanisms involved in biofilm dispersal.",
author = "Morten Harmsen and Liang Yang and Pamp, {S{\"u}nje J} and Tim Tolker-Nielsen",
year = "2010",
doi = "10.1111/j.1574-695X.2010.00690.x",
language = "English",
volume = "59",
pages = "253--68",
journal = "Pathogens and Disease",
issn = "2049-632X",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal

AU - Harmsen, Morten

AU - Yang, Liang

AU - Pamp, Sünje J

AU - Tolker-Nielsen, Tim

PY - 2010

Y1 - 2010

N2 - We review the recent advances in the understanding of the Pseudomonas aeruginosa biofilm lifestyle from studies using in vitro laboratory setups such as flow chambers and microtiter trays. Recent work sheds light on the role of nutrients, motility, and quorum sensing in structure formation in P. aeruginosa biofilms. The second messenger, c-di-GMP, is established as an important regulator of the synthesis of polysaccharide and protein components of the biofilm matrix. Extracellular DNA is shown to be an essential component of the biofilm matrix. It has become apparent that biofilm formation involves interactions between different subpopulations. The molecular mechanisms underlying the tolerance of biofilm bacteria to antimicrobial agents are beginning to be unraveled, and new knowledge has been obtained regarding the environmental cues and regulatory mechanisms involved in biofilm dispersal.

AB - We review the recent advances in the understanding of the Pseudomonas aeruginosa biofilm lifestyle from studies using in vitro laboratory setups such as flow chambers and microtiter trays. Recent work sheds light on the role of nutrients, motility, and quorum sensing in structure formation in P. aeruginosa biofilms. The second messenger, c-di-GMP, is established as an important regulator of the synthesis of polysaccharide and protein components of the biofilm matrix. Extracellular DNA is shown to be an essential component of the biofilm matrix. It has become apparent that biofilm formation involves interactions between different subpopulations. The molecular mechanisms underlying the tolerance of biofilm bacteria to antimicrobial agents are beginning to be unraveled, and new knowledge has been obtained regarding the environmental cues and regulatory mechanisms involved in biofilm dispersal.

U2 - 10.1111/j.1574-695X.2010.00690.x

DO - 10.1111/j.1574-695X.2010.00690.x

M3 - Journal article

C2 - 20497222

VL - 59

SP - 253

EP - 268

JO - Pathogens and Disease

JF - Pathogens and Disease

SN - 2049-632X

IS - 3

ER -

ID: 22361301