Antibiotic treatment of biofilm infections

Research output: Contribution to journal › Review › Research › peer-review

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Antibiotic treatment of biofilm infections. / Ciofu, Oana; Rojo-Molinero, Estrella; Macià, María D.; Oliver, Antonio.

In: APMIS, Vol. 125, No. 4, 04.2017, p. 304-319.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Ciofu, O, Rojo-Molinero, E, Macià, MD & Oliver, A 2017, 'Antibiotic treatment of biofilm infections', APMIS, vol. 125, no. 4, pp. 304-319. https://doi.org/10.1111/apm.12673

APA

Ciofu, O., Rojo-Molinero, E., Macià, M. D., & Oliver, A. (2017). Antibiotic treatment of biofilm infections. APMIS, 125(4), 304-319. https://doi.org/10.1111/apm.12673

Vancouver

Ciofu O, Rojo-Molinero E, Macià MD, Oliver A. Antibiotic treatment of biofilm infections. APMIS. 2017 Apr;125(4):304-319. https://doi.org/10.1111/apm.12673

Author

Ciofu, Oana ; Rojo-Molinero, Estrella ; Macià, María D. ; Oliver, Antonio. / Antibiotic treatment of biofilm infections. In: APMIS. 2017 ; Vol. 125, No. 4. pp. 304-319.

Bibtex

@article{11a16d5cf7e24fb49d629eae7d5abc9f,
title = "Antibiotic treatment of biofilm infections",
abstract = "Bacterial biofilms are associated with a wide range of infections, from those related to exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such as those occurring in the lungs of cystic fibrosis patients. Biofilms are recalcitrant to antibiotic treatment due to multiple tolerance mechanisms (phenotypic resistance). This causes persistence of biofilm infections in spite of antibiotic exposure which predisposes to antibiotic resistance development (genetic resistance). Understanding the interplay between phenotypic and genetic resistance mechanisms acting on biofilms, as well as appreciating the diversity of environmental conditions of biofilm infections which influence the effect of antibiotics are required in order to optimize the antibiotic treatment of biofilm infections. Here, we review the current knowledge on phenotypic and genetic resistance in biofilms and describe the potential strategies for the antibiotic treatment of biofilm infections. Of note is the optimization of PK/PD parameters in biofilms, high-dose topical treatments, combined and sequential/alternate therapies or the use antibiotic adjuvants.",
keywords = "antibiotic resistance, antibiotic tolerance, Antibiotics, biofilms, combination therapy, topical treatment",
author = "Oana Ciofu and Estrella Rojo-Molinero and Maci{\`a}, {Mar{\'i}a D.} and Antonio Oliver",
year = "2017",
month = apr,
doi = "10.1111/apm.12673",
language = "English",
volume = "125",
pages = "304--319",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "4",

}

RIS

TY - JOUR

T1 - Antibiotic treatment of biofilm infections

AU - Ciofu, Oana

AU - Rojo-Molinero, Estrella

AU - Macià, María D.

AU - Oliver, Antonio

PY - 2017/4

Y1 - 2017/4

N2 - Bacterial biofilms are associated with a wide range of infections, from those related to exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such as those occurring in the lungs of cystic fibrosis patients. Biofilms are recalcitrant to antibiotic treatment due to multiple tolerance mechanisms (phenotypic resistance). This causes persistence of biofilm infections in spite of antibiotic exposure which predisposes to antibiotic resistance development (genetic resistance). Understanding the interplay between phenotypic and genetic resistance mechanisms acting on biofilms, as well as appreciating the diversity of environmental conditions of biofilm infections which influence the effect of antibiotics are required in order to optimize the antibiotic treatment of biofilm infections. Here, we review the current knowledge on phenotypic and genetic resistance in biofilms and describe the potential strategies for the antibiotic treatment of biofilm infections. Of note is the optimization of PK/PD parameters in biofilms, high-dose topical treatments, combined and sequential/alternate therapies or the use antibiotic adjuvants.

AB - Bacterial biofilms are associated with a wide range of infections, from those related to exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such as those occurring in the lungs of cystic fibrosis patients. Biofilms are recalcitrant to antibiotic treatment due to multiple tolerance mechanisms (phenotypic resistance). This causes persistence of biofilm infections in spite of antibiotic exposure which predisposes to antibiotic resistance development (genetic resistance). Understanding the interplay between phenotypic and genetic resistance mechanisms acting on biofilms, as well as appreciating the diversity of environmental conditions of biofilm infections which influence the effect of antibiotics are required in order to optimize the antibiotic treatment of biofilm infections. Here, we review the current knowledge on phenotypic and genetic resistance in biofilms and describe the potential strategies for the antibiotic treatment of biofilm infections. Of note is the optimization of PK/PD parameters in biofilms, high-dose topical treatments, combined and sequential/alternate therapies or the use antibiotic adjuvants.

KW - antibiotic resistance

KW - antibiotic tolerance

KW - Antibiotics

KW - biofilms

KW - combination therapy

KW - topical treatment

U2 - 10.1111/apm.12673

DO - 10.1111/apm.12673

M3 - Review

C2 - 28407419

AN - SCOPUS:85017528777

VL - 125

SP - 304

EP - 319

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 4

ER -

ID: 187265091