Bacteria-triggered release of antimicrobial agents

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bacteria-triggered release of antimicrobial agents. / Komnatnyy, Vitaly V; Chiang, Wen-Chi; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas E.

In: Angewandte Chemie (International ed. in English), Vol. 53, No. 2, 07.01.2014, p. 439-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Komnatnyy, VV, Chiang, W-C, Tolker-Nielsen, T, Givskov, M & Nielsen, TE 2014, 'Bacteria-triggered release of antimicrobial agents', Angewandte Chemie (International ed. in English), vol. 53, no. 2, pp. 439-41. https://doi.org/10.1002/anie.201307975

APA

Komnatnyy, V. V., Chiang, W-C., Tolker-Nielsen, T., Givskov, M., & Nielsen, T. E. (2014). Bacteria-triggered release of antimicrobial agents. Angewandte Chemie (International ed. in English), 53(2), 439-41. https://doi.org/10.1002/anie.201307975

Vancouver

Komnatnyy VV, Chiang W-C, Tolker-Nielsen T, Givskov M, Nielsen TE. Bacteria-triggered release of antimicrobial agents. Angewandte Chemie (International ed. in English). 2014 Jan 7;53(2):439-41. https://doi.org/10.1002/anie.201307975

Author

Komnatnyy, Vitaly V ; Chiang, Wen-Chi ; Tolker-Nielsen, Tim ; Givskov, Michael ; Nielsen, Thomas E. / Bacteria-triggered release of antimicrobial agents. In: Angewandte Chemie (International ed. in English). 2014 ; Vol. 53, No. 2. pp. 439-41.

Bibtex

@article{4c31eea6e39a46f989c21639e44cceee,
title = "Bacteria-triggered release of antimicrobial agents",
abstract = "Medical devices employed in healthcare practice are often susceptible to microbial contamination. Pathogenic bacteria may attach themselves to device surfaces of catheters or implants by formation of chemically complex biofilms, which may be the direct cause of device failure. Extracellular bacterial lipases are particularly abundant at sites of infection. Herein it is shown how active or proactive compounds attached to polymeric surfaces using lipase-sensitive linkages, such as fatty acid esters or anhydrides, may be released in response to infection. Proof-of-concept of the responsive material is demonstrated by the bacteria-triggered release of antibiotics to control bacterial populations and signaling molecules to modulate quorum sensing. The self-regulating system provides the basis for the development of device-relevant polymeric materials, which only release antibiotics in dependency of the titer of bacteria surrounding the medical device.",
keywords = "Anhydrides, Anti-Bacterial Agents, Bacterial Adhesion, Biofilms, Lipase, Molecular Structure, Polymers, Prostheses and Implants, Prosthesis-Related Infections, Pseudomonas aeruginosa, Quorum Sensing, Substrate Specificity, Surface Properties",
author = "Komnatnyy, {Vitaly V} and Wen-Chi Chiang and Tim Tolker-Nielsen and Michael Givskov and Nielsen, {Thomas E}",
note = "Copyright {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2014",
month = jan,
day = "7",
doi = "10.1002/anie.201307975",
language = "English",
volume = "53",
pages = "439--41",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "2",

}

RIS

TY - JOUR

T1 - Bacteria-triggered release of antimicrobial agents

AU - Komnatnyy, Vitaly V

AU - Chiang, Wen-Chi

AU - Tolker-Nielsen, Tim

AU - Givskov, Michael

AU - Nielsen, Thomas E

N1 - Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2014/1/7

Y1 - 2014/1/7

N2 - Medical devices employed in healthcare practice are often susceptible to microbial contamination. Pathogenic bacteria may attach themselves to device surfaces of catheters or implants by formation of chemically complex biofilms, which may be the direct cause of device failure. Extracellular bacterial lipases are particularly abundant at sites of infection. Herein it is shown how active or proactive compounds attached to polymeric surfaces using lipase-sensitive linkages, such as fatty acid esters or anhydrides, may be released in response to infection. Proof-of-concept of the responsive material is demonstrated by the bacteria-triggered release of antibiotics to control bacterial populations and signaling molecules to modulate quorum sensing. The self-regulating system provides the basis for the development of device-relevant polymeric materials, which only release antibiotics in dependency of the titer of bacteria surrounding the medical device.

AB - Medical devices employed in healthcare practice are often susceptible to microbial contamination. Pathogenic bacteria may attach themselves to device surfaces of catheters or implants by formation of chemically complex biofilms, which may be the direct cause of device failure. Extracellular bacterial lipases are particularly abundant at sites of infection. Herein it is shown how active or proactive compounds attached to polymeric surfaces using lipase-sensitive linkages, such as fatty acid esters or anhydrides, may be released in response to infection. Proof-of-concept of the responsive material is demonstrated by the bacteria-triggered release of antibiotics to control bacterial populations and signaling molecules to modulate quorum sensing. The self-regulating system provides the basis for the development of device-relevant polymeric materials, which only release antibiotics in dependency of the titer of bacteria surrounding the medical device.

KW - Anhydrides

KW - Anti-Bacterial Agents

KW - Bacterial Adhesion

KW - Biofilms

KW - Lipase

KW - Molecular Structure

KW - Polymers

KW - Prostheses and Implants

KW - Prosthesis-Related Infections

KW - Pseudomonas aeruginosa

KW - Quorum Sensing

KW - Substrate Specificity

KW - Surface Properties

U2 - 10.1002/anie.201307975

DO - 10.1002/anie.201307975

M3 - Journal article

C2 - 24288347

VL - 53

SP - 439

EP - 441

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 2

ER -

ID: 129018745