Bead-based screening in chemical biology and drug discovery

Research output: Contribution to journal › Journal article › Research › peer-review

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Bead-based screening in chemical biology and drug discovery. / Komnatnyy, Vitaly V.; Nielsen, Thomas E.; Qvortrup, Katrine.

In: Chemical Communications, Vol. 54, No. 50, 2018, p. 6759-6771.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Komnatnyy, VV, Nielsen, TE & Qvortrup, K 2018, 'Bead-based screening in chemical biology and drug discovery', Chemical Communications, vol. 54, no. 50, pp. 6759-6771. https://doi.org/10.1039/c8cc02486c

APA

Komnatnyy, V. V., Nielsen, T. E., & Qvortrup, K. (2018). Bead-based screening in chemical biology and drug discovery. Chemical Communications, 54(50), 6759-6771. https://doi.org/10.1039/c8cc02486c

Vancouver

Komnatnyy VV, Nielsen TE, Qvortrup K. Bead-based screening in chemical biology and drug discovery. Chemical Communications. 2018;54(50):6759-6771. https://doi.org/10.1039/c8cc02486c

Author

Komnatnyy, Vitaly V. ; Nielsen, Thomas E. ; Qvortrup, Katrine. / Bead-based screening in chemical biology and drug discovery. In: Chemical Communications. 2018 ; Vol. 54, No. 50. pp. 6759-6771.

Bibtex

@article{2c77086b63dd401a9056c9d926205f7b,
title = "Bead-based screening in chemical biology and drug discovery",
abstract = "High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amenable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structurally diverse libraries for early drug discovery. Among the various library forms, the one-bead-one-compound (OBOC) library, where each bead carries many copies of a single compound, holds the greatest potential for the rapid identification of novel hits against emerging drug targets. However, this potential has not yet been fully realized due to a number of technical obstacles. In this feature article, we review the progress that has been made in bead-based library screening and its application to the discovery of bioactive compounds. We identify the key challenges of this approach and highlight key steps needed for making a greater impact in the field.",
author = "Komnatnyy, {Vitaly V.} and Nielsen, {Thomas E.} and Katrine Qvortrup",
year = "2018",
doi = "10.1039/c8cc02486c",
language = "English",
volume = "54",
pages = "6759--6771",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "50",

}

RIS

TY - JOUR

T1 - Bead-based screening in chemical biology and drug discovery

AU - Komnatnyy, Vitaly V.

AU - Nielsen, Thomas E.

AU - Qvortrup, Katrine

PY - 2018

Y1 - 2018

N2 - High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amenable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structurally diverse libraries for early drug discovery. Among the various library forms, the one-bead-one-compound (OBOC) library, where each bead carries many copies of a single compound, holds the greatest potential for the rapid identification of novel hits against emerging drug targets. However, this potential has not yet been fully realized due to a number of technical obstacles. In this feature article, we review the progress that has been made in bead-based library screening and its application to the discovery of bioactive compounds. We identify the key challenges of this approach and highlight key steps needed for making a greater impact in the field.

AB - High-throughput screening is an important component of the drug discovery process. The screening of libraries containing hundreds of thousands of compounds requires assays amenable to miniaturisation and automization. Combinatorial chemistry holds a unique promise to deliver structurally diverse libraries for early drug discovery. Among the various library forms, the one-bead-one-compound (OBOC) library, where each bead carries many copies of a single compound, holds the greatest potential for the rapid identification of novel hits against emerging drug targets. However, this potential has not yet been fully realized due to a number of technical obstacles. In this feature article, we review the progress that has been made in bead-based library screening and its application to the discovery of bioactive compounds. We identify the key challenges of this approach and highlight key steps needed for making a greater impact in the field.

U2 - 10.1039/c8cc02486c

DO - 10.1039/c8cc02486c

M3 - Journal article

C2 - 29888365

AN - SCOPUS:85048761432

VL - 54

SP - 6759

EP - 6771

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 50

ER -

ID: 208886864