Biofilm and equine limb wounds

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Biofilm and equine limb wounds. / Jørgensen, Elin; Bjarnsholt, Thomas; Jacobsen, Stine.

In: Animals, Vol. 11, No. 10, 2825, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Jørgensen, E, Bjarnsholt, T & Jacobsen, S 2021, 'Biofilm and equine limb wounds', Animals, vol. 11, no. 10, 2825. https://doi.org/10.3390/ani11102825

APA

Jørgensen, E., Bjarnsholt, T., & Jacobsen, S. (2021). Biofilm and equine limb wounds. Animals, 11(10), [2825]. https://doi.org/10.3390/ani11102825

Vancouver

Jørgensen E, Bjarnsholt T, Jacobsen S. Biofilm and equine limb wounds. Animals. 2021;11(10). 2825. https://doi.org/10.3390/ani11102825

Author

Jørgensen, Elin ; Bjarnsholt, Thomas ; Jacobsen, Stine. / Biofilm and equine limb wounds. In: Animals. 2021 ; Vol. 11, No. 10.

Bibtex

@article{83d559073a334ac687deee7300d75935,
title = "Biofilm and equine limb wounds",
abstract = "In chronic wounds in humans, biofilm formation and wound chronicity are linked, as biofilms contribute to chronic inflammation and delayed healing. Biofilms are aggregates of bacteria, and living as biofilms is the default mode of bacterial life; within these aggregates, the bacteria are protected from both antimicrobial substances and the immune response of the host. In horses, delayed healing is more commonly seen in limb wounds than body wounds. Chronic inflammation and hypoxia are the main characteristics of delayed wound healing in equine limbs, and biofilms might also contribute to this healing pattern in horses. However, biofilm formation in equine wounds has been studied to a very limited degree. Biofilms have been detected in equine traumatic wounds, and recent experimental models have shown that biofilms protract the healing of equine limb wounds. Detection of biofilms within wounds necessitates advanced techniques that are not available in routine diagnostic yet. However, infections with biofilm should be suspected in equine limb wounds not healing as expected, as they are in human wounds. Treatment should be based on repeated debridement and application of topical antimicrobial therapy.",
keywords = "Bacterial aggregates, Biofilm, Delayed wound healing, Horse, Infection, Wound, Wound chronicity",
author = "Elin J{\o}rgensen and Thomas Bjarnsholt and Stine Jacobsen",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
doi = "10.3390/ani11102825",
language = "English",
volume = "11",
journal = "Animals",
issn = "2076-2615",
publisher = "MDPI",
number = "10",

}

RIS

TY - JOUR

T1 - Biofilm and equine limb wounds

AU - Jørgensen, Elin

AU - Bjarnsholt, Thomas

AU - Jacobsen, Stine

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - In chronic wounds in humans, biofilm formation and wound chronicity are linked, as biofilms contribute to chronic inflammation and delayed healing. Biofilms are aggregates of bacteria, and living as biofilms is the default mode of bacterial life; within these aggregates, the bacteria are protected from both antimicrobial substances and the immune response of the host. In horses, delayed healing is more commonly seen in limb wounds than body wounds. Chronic inflammation and hypoxia are the main characteristics of delayed wound healing in equine limbs, and biofilms might also contribute to this healing pattern in horses. However, biofilm formation in equine wounds has been studied to a very limited degree. Biofilms have been detected in equine traumatic wounds, and recent experimental models have shown that biofilms protract the healing of equine limb wounds. Detection of biofilms within wounds necessitates advanced techniques that are not available in routine diagnostic yet. However, infections with biofilm should be suspected in equine limb wounds not healing as expected, as they are in human wounds. Treatment should be based on repeated debridement and application of topical antimicrobial therapy.

AB - In chronic wounds in humans, biofilm formation and wound chronicity are linked, as biofilms contribute to chronic inflammation and delayed healing. Biofilms are aggregates of bacteria, and living as biofilms is the default mode of bacterial life; within these aggregates, the bacteria are protected from both antimicrobial substances and the immune response of the host. In horses, delayed healing is more commonly seen in limb wounds than body wounds. Chronic inflammation and hypoxia are the main characteristics of delayed wound healing in equine limbs, and biofilms might also contribute to this healing pattern in horses. However, biofilm formation in equine wounds has been studied to a very limited degree. Biofilms have been detected in equine traumatic wounds, and recent experimental models have shown that biofilms protract the healing of equine limb wounds. Detection of biofilms within wounds necessitates advanced techniques that are not available in routine diagnostic yet. However, infections with biofilm should be suspected in equine limb wounds not healing as expected, as they are in human wounds. Treatment should be based on repeated debridement and application of topical antimicrobial therapy.

KW - Bacterial aggregates

KW - Biofilm

KW - Delayed wound healing

KW - Horse

KW - Infection

KW - Wound

KW - Wound chronicity

U2 - 10.3390/ani11102825

DO - 10.3390/ani11102825

M3 - Review

C2 - 34679846

AN - SCOPUS:85115773735

VL - 11

JO - Animals

JF - Animals

SN - 2076-2615

IS - 10

M1 - 2825

ER -

ID: 281156051