Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections. / Kristensen, Rasmus; Tolker-Nielsen, Tim; Jakobsen, Tim Holm.

Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, 2022. p. 159-179 (Springer Series on Biofilms; No. 11).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Kristensen, R, Tolker-Nielsen, T & Jakobsen, TH 2022, Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections. in Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, Springer Series on Biofilms, no. 11, pp. 159-179.

APA

Kristensen, R., Tolker-Nielsen, T., & Jakobsen, T. H. (2022). Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections. In Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms (pp. 159-179). Springer. Springer Series on Biofilms No. 11

Vancouver

Kristensen R, Tolker-Nielsen T, Jakobsen TH. Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections. In Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer. 2022. p. 159-179. (Springer Series on Biofilms; No. 11).

Author

Kristensen, Rasmus ; Tolker-Nielsen, Tim ; Jakobsen, Tim Holm. / Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections. Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Springer, 2022. pp. 159-179 (Springer Series on Biofilms; No. 11).

Bibtex

@inbook{c9c0b43e891e45208e1a214978195e8c,
title = "Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections",
abstract = "At the end of the last century, bacterial biofilms were recognised as being a common cause of persistent infections. This finding encouraged intense research in biofilms, revealing that the biofilm life form is an essential factor for bacteria to develop persistent infections, which is because of an increased resistance to the immune system and conventional antibiotics. However, the increased scientific focus on studying the underlying mechanisms of biofilm formation has not yet led to the development of efficient therapeutic applications to eradicate biofilm infections, and treatment of these infections remains a critical struggle for physicians. The bacterial cell-to-cell quorum-sensing signalling system and the intracellular cyclic-di-GMP signalling system have gained increasing attention as potential targets for the treatment of persistent biofilm infections. Here, we describe these two systems in relation to virulence and regulation of biofilm formation in Pseudomonas aeruginosa. We also describe the potential use of small molecules to chemically interfere with these systems for treatment purposes, and we review the scientific development and novel findings of compounds that have been identified as potential modulators of the two regulatory processes.",
author = "Rasmus Kristensen and Tim Tolker-Nielsen and Jakobsen, {Tim Holm}",
year = "2022",
language = "English",
isbn = "978-3-031-10991-1",
series = "Springer Series on Biofilms",
publisher = "Springer",
number = "11",
pages = "159--179",
booktitle = "Antibiofilm Strategies",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - Chemical Regulation of Pseudomonas aeruginosa Biofilm Formation as a Potential Treatment for Persistent Infections

AU - Kristensen, Rasmus

AU - Tolker-Nielsen, Tim

AU - Jakobsen, Tim Holm

PY - 2022

Y1 - 2022

N2 - At the end of the last century, bacterial biofilms were recognised as being a common cause of persistent infections. This finding encouraged intense research in biofilms, revealing that the biofilm life form is an essential factor for bacteria to develop persistent infections, which is because of an increased resistance to the immune system and conventional antibiotics. However, the increased scientific focus on studying the underlying mechanisms of biofilm formation has not yet led to the development of efficient therapeutic applications to eradicate biofilm infections, and treatment of these infections remains a critical struggle for physicians. The bacterial cell-to-cell quorum-sensing signalling system and the intracellular cyclic-di-GMP signalling system have gained increasing attention as potential targets for the treatment of persistent biofilm infections. Here, we describe these two systems in relation to virulence and regulation of biofilm formation in Pseudomonas aeruginosa. We also describe the potential use of small molecules to chemically interfere with these systems for treatment purposes, and we review the scientific development and novel findings of compounds that have been identified as potential modulators of the two regulatory processes.

AB - At the end of the last century, bacterial biofilms were recognised as being a common cause of persistent infections. This finding encouraged intense research in biofilms, revealing that the biofilm life form is an essential factor for bacteria to develop persistent infections, which is because of an increased resistance to the immune system and conventional antibiotics. However, the increased scientific focus on studying the underlying mechanisms of biofilm formation has not yet led to the development of efficient therapeutic applications to eradicate biofilm infections, and treatment of these infections remains a critical struggle for physicians. The bacterial cell-to-cell quorum-sensing signalling system and the intracellular cyclic-di-GMP signalling system have gained increasing attention as potential targets for the treatment of persistent biofilm infections. Here, we describe these two systems in relation to virulence and regulation of biofilm formation in Pseudomonas aeruginosa. We also describe the potential use of small molecules to chemically interfere with these systems for treatment purposes, and we review the scientific development and novel findings of compounds that have been identified as potential modulators of the two regulatory processes.

M3 - Book chapter

SN - 978-3-031-10991-1

T3 - Springer Series on Biofilms

SP - 159

EP - 179

BT - Antibiofilm Strategies

PB - Springer

ER -

ID: 385019755