Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice

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Standard

Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. / Moser, C; Johansen, H K; Song, Z; Hougen, H P; Rygaard, J; Høiby, N.

In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 105, No. 11, 1997, p. 838-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Moser, C, Johansen, HK, Song, Z, Hougen, HP, Rygaard, J & Høiby, N 1997, 'Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 105, no. 11, pp. 838-42.

APA

Moser, C., Johansen, H. K., Song, Z., Hougen, H. P., Rygaard, J., & Høiby, N. (1997). Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, 105(11), 838-42.

Vancouver

Moser C, Johansen HK, Song Z, Hougen HP, Rygaard J, Høiby N. Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 1997;105(11):838-42.

Author

Moser, C ; Johansen, H K ; Song, Z ; Hougen, H P ; Rygaard, J ; Høiby, N. / Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice. In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 1997 ; Vol. 105, No. 11. pp. 838-42.

Bibtex

@article{7a8a8276aa0f4055aa6f6ab5385f04be,
title = "Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice",
abstract = "The chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) is characterized by a pronounced antibody response and microcolonies surrounded by numerous polymorphonuclear neutrophils (PMN). Poor prognosis is correlated with a high antibody response to P. aeruginosa antigens. An animal model of this infection was established in two strains of mice: C3H/HeN and BALB/c, generally known as Th1 and Th2 responders, respectively, which were challenged with alginate-embedded P. aeruginosa. Mortality was significantly lower in C3H/HeN compared to BALB/c mice (p <0.025). P. aeruginosa was cleared more efficiently in C3H/HeN mice and significantly more C3H/HeN mice showed normal lung histopathology (p <0.02), and we found significantly fewer microabscesses in C3H/HeN mice than in BALB/c mice (p <0.005). In supernatants from P. aeruginosa antigen and concanavalin A-stimulated spleen cells from the two strains of mice, the interferon-(IFN-) gamma levels were higher, whereas IL-4 levels were lower in C3H/HeN mice than in BALB/c mice. The implications of these findings for CF patients with chronic P. aeruginosa lung infection are discussed.",
keywords = "Animals, Chronic Disease, Female, Interferon-gamma, Interleukin-4, Lymphocyte Activation, Mice, Mice, Inbred BALB C, Mice, Inbred C3H, Pneumonia, Bacterial, Pseudomonas Infections, Pseudomonas aeruginosa, Spleen, Th1 Cells, Th2 Cells",
author = "C Moser and Johansen, {H K} and Z Song and Hougen, {H P} and J Rygaard and N H{\o}iby",
year = "1997",
language = "English",
volume = "105",
pages = "838--42",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "11",

}

RIS

TY - JOUR

T1 - Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice

AU - Moser, C

AU - Johansen, H K

AU - Song, Z

AU - Hougen, H P

AU - Rygaard, J

AU - Høiby, N

PY - 1997

Y1 - 1997

N2 - The chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) is characterized by a pronounced antibody response and microcolonies surrounded by numerous polymorphonuclear neutrophils (PMN). Poor prognosis is correlated with a high antibody response to P. aeruginosa antigens. An animal model of this infection was established in two strains of mice: C3H/HeN and BALB/c, generally known as Th1 and Th2 responders, respectively, which were challenged with alginate-embedded P. aeruginosa. Mortality was significantly lower in C3H/HeN compared to BALB/c mice (p <0.025). P. aeruginosa was cleared more efficiently in C3H/HeN mice and significantly more C3H/HeN mice showed normal lung histopathology (p <0.02), and we found significantly fewer microabscesses in C3H/HeN mice than in BALB/c mice (p <0.005). In supernatants from P. aeruginosa antigen and concanavalin A-stimulated spleen cells from the two strains of mice, the interferon-(IFN-) gamma levels were higher, whereas IL-4 levels were lower in C3H/HeN mice than in BALB/c mice. The implications of these findings for CF patients with chronic P. aeruginosa lung infection are discussed.

AB - The chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) is characterized by a pronounced antibody response and microcolonies surrounded by numerous polymorphonuclear neutrophils (PMN). Poor prognosis is correlated with a high antibody response to P. aeruginosa antigens. An animal model of this infection was established in two strains of mice: C3H/HeN and BALB/c, generally known as Th1 and Th2 responders, respectively, which were challenged with alginate-embedded P. aeruginosa. Mortality was significantly lower in C3H/HeN compared to BALB/c mice (p <0.025). P. aeruginosa was cleared more efficiently in C3H/HeN mice and significantly more C3H/HeN mice showed normal lung histopathology (p <0.02), and we found significantly fewer microabscesses in C3H/HeN mice than in BALB/c mice (p <0.005). In supernatants from P. aeruginosa antigen and concanavalin A-stimulated spleen cells from the two strains of mice, the interferon-(IFN-) gamma levels were higher, whereas IL-4 levels were lower in C3H/HeN mice than in BALB/c mice. The implications of these findings for CF patients with chronic P. aeruginosa lung infection are discussed.

KW - Animals

KW - Chronic Disease

KW - Female

KW - Interferon-gamma

KW - Interleukin-4

KW - Lymphocyte Activation

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C3H

KW - Pneumonia, Bacterial

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - Spleen

KW - Th1 Cells

KW - Th2 Cells

M3 - Journal article

C2 - 9393554

VL - 105

SP - 838

EP - 842

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 11

ER -

ID: 44354112