Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis
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Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis. / Dalbøge, C S; Hansen, C R; Pressler, T; Høiby, N; Johansen, H K.
In: Journal of Cystic Fibrosis, Vol. 10, No. 5, 01.09.2011, p. 318-25.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis
AU - Dalbøge, C S
AU - Hansen, C R
AU - Pressler, T
AU - Høiby, N
AU - Johansen, H K
N1 - Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Background The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear. Method All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2years without any other chronic Gram-negative infection were matched to two non-infected CF controls. Results Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV1 compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3years before the patients became chronically infected. Discussions Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.
AB - Background The clinical consequences of chronic Stenotrophomonas maltophilia infection in cystic fibrosis (CF) patient are still unclear. Method All patients treated in the Copenhagen CF centre (N=278) from 1 January 2008 to 31 December 2009 were included. Each patient chronically infected with S. maltophilia for at least 2years without any other chronic Gram-negative infection were matched to two non-infected CF controls. Results Twenty-one patients were chronically infected with S. maltophilia during the 2-year study period. Fifteen were infected for at least 2years. The patients in the S. maltophilia group had a steeper decline (-3.2%/year vs. -0.3%/year) in FEV1 compared to the non-infected CF controls (P=0.03). The rate of decline was the same as observed 3years before the patients became chronically infected. Discussions Chronic infection with S. maltophilia does not lead to a steeper decline in lung function when compared to the period before chronic infection.
U2 - 10.1016/j.jcf.2011.03.006
DO - 10.1016/j.jcf.2011.03.006
M3 - Journal article
C2 - 21463972
VL - 10
SP - 318
EP - 325
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
IS - 5
ER -
ID: 40216887