Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms. / Armengol, Eva; Kragh, Kasper Nørskov; Tolker-Nielsen, Tim; Sierra, Josep M.; Higazy, Doaa; Ciofu, Oana; Viñas, Miguel; Høiby, Niels.

In: Antimicrobial Agents and Chemotherapy, Vol. 67, No. 4, e0164122, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Armengol, E, Kragh, KN, Tolker-Nielsen, T, Sierra, JM, Higazy, D, Ciofu, O, Viñas, M & Høiby, N 2023, 'Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms', Antimicrobial Agents and Chemotherapy, vol. 67, no. 4, e0164122. https://doi.org/10.1128/aac.01641-22

APA

Armengol, E., Kragh, K. N., Tolker-Nielsen, T., Sierra, J. M., Higazy, D., Ciofu, O., Viñas, M., & Høiby, N. (2023). Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms. Antimicrobial Agents and Chemotherapy, 67(4), [e0164122]. https://doi.org/10.1128/aac.01641-22

Vancouver

Armengol E, Kragh KN, Tolker-Nielsen T, Sierra JM, Higazy D, Ciofu O et al. Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms. Antimicrobial Agents and Chemotherapy. 2023;67(4). e0164122. https://doi.org/10.1128/aac.01641-22

Author

Armengol, Eva ; Kragh, Kasper Nørskov ; Tolker-Nielsen, Tim ; Sierra, Josep M. ; Higazy, Doaa ; Ciofu, Oana ; Viñas, Miguel ; Høiby, Niels. / Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms. In: Antimicrobial Agents and Chemotherapy. 2023 ; Vol. 67, No. 4.

Bibtex

@article{726fc19d9fb045de88c3eb75bda4fdc4,
title = "Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms",
abstract = "The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the need to find new strategies, such as the use of combinations of antibiotics. Among these, the combination of colistin with other antibiotics has been studied. Here, the action of combinations of colistin and rifampicin on both planktonic and sessile cells of colistin-resistant P. aeruginosa was studied. Dynamic biofilms were formed and treated with such a combination, resulting in an active killing effect of both colistin-resistant and colistin-susceptible P. aeruginosa in biofilms. The results suggest that the action of colistin on the outer membrane facilitates rifampicin penetration, regardless of the colistin-resistant phenotype. Based on these in vitro data, we propose a colistin-rifampicin combination as a promising treatment for infections caused by colistin-resistant P. aeruginosa.",
keywords = "biofilm, colistin, dynamic, rifampicin, synergism",
author = "Eva Armengol and Kragh, {Kasper N{\o}rskov} and Tim Tolker-Nielsen and Sierra, {Josep M.} and Doaa Higazy and Oana Ciofu and Miguel Vi{\~n}as and Niels H{\o}iby",
year = "2023",
doi = "10.1128/aac.01641-22",
language = "English",
volume = "67",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "4",

}

RIS

TY - JOUR

T1 - Colistin Enhances Rifampicin's Antimicrobial Action in Colistin-Resistant Pseudomonas aeruginosa Biofilms

AU - Armengol, Eva

AU - Kragh, Kasper Nørskov

AU - Tolker-Nielsen, Tim

AU - Sierra, Josep M.

AU - Higazy, Doaa

AU - Ciofu, Oana

AU - Viñas, Miguel

AU - Høiby, Niels

PY - 2023

Y1 - 2023

N2 - The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the need to find new strategies, such as the use of combinations of antibiotics. Among these, the combination of colistin with other antibiotics has been studied. Here, the action of combinations of colistin and rifampicin on both planktonic and sessile cells of colistin-resistant P. aeruginosa was studied. Dynamic biofilms were formed and treated with such a combination, resulting in an active killing effect of both colistin-resistant and colistin-susceptible P. aeruginosa in biofilms. The results suggest that the action of colistin on the outer membrane facilitates rifampicin penetration, regardless of the colistin-resistant phenotype. Based on these in vitro data, we propose a colistin-rifampicin combination as a promising treatment for infections caused by colistin-resistant P. aeruginosa.

AB - The emergence of multidrug-resistant Pseudomonas aeruginosa infections has urged the need to find new strategies, such as the use of combinations of antibiotics. Among these, the combination of colistin with other antibiotics has been studied. Here, the action of combinations of colistin and rifampicin on both planktonic and sessile cells of colistin-resistant P. aeruginosa was studied. Dynamic biofilms were formed and treated with such a combination, resulting in an active killing effect of both colistin-resistant and colistin-susceptible P. aeruginosa in biofilms. The results suggest that the action of colistin on the outer membrane facilitates rifampicin penetration, regardless of the colistin-resistant phenotype. Based on these in vitro data, we propose a colistin-rifampicin combination as a promising treatment for infections caused by colistin-resistant P. aeruginosa.

KW - biofilm

KW - colistin

KW - dynamic

KW - rifampicin

KW - synergism

U2 - 10.1128/aac.01641-22

DO - 10.1128/aac.01641-22

M3 - Journal article

C2 - 36856424

AN - SCOPUS:85152976339

VL - 67

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 4

M1 - e0164122

ER -

ID: 345416535