Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

Research output: Contribution to journal › Letter › Research › peer-review

Standard

Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. / Sun, Jiadong; Marais, Jannie P J; Khoo, Christina; LaPlante, Kerry; Vejborg, Rebecca M; Givskov, Michael; Tolker-Nielsen, Tim; Seeram, Navindra P; Rowley, David C.

In: Journal of Functional Foods, Vol. 17, 08.2015, p. 235-242.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Sun, J, Marais, JPJ, Khoo, C, LaPlante, K, Vejborg, RM, Givskov, M, Tolker-Nielsen, T, Seeram, NP & Rowley, DC 2015, 'Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli', Journal of Functional Foods, vol. 17, pp. 235-242. https://doi.org/10.1016/j.jff.2015.05.016

APA

Sun, J., Marais, J. P. J., Khoo, C., LaPlante, K., Vejborg, R. M., Givskov, M., Tolker-Nielsen, T., Seeram, N. P., & Rowley, D. C. (2015). Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. Journal of Functional Foods, 17, 235-242. https://doi.org/10.1016/j.jff.2015.05.016

Vancouver

Sun J, Marais JPJ, Khoo C, LaPlante K, Vejborg RM, Givskov M et al. Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. Journal of Functional Foods. 2015 Aug;17:235-242. https://doi.org/10.1016/j.jff.2015.05.016

Author

Sun, Jiadong ; Marais, Jannie P J ; Khoo, Christina ; LaPlante, Kerry ; Vejborg, Rebecca M ; Givskov, Michael ; Tolker-Nielsen, Tim ; Seeram, Navindra P ; Rowley, David C. / Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. In: Journal of Functional Foods. 2015 ; Vol. 17. pp. 235-242.

Bibtex

@article{1e8fc7a7856b429f9b89b4c4bd27a589,
title = "Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli",
abstract = "The preventive effects of the American cranberry (Vaccinium macrocarpon) against urinary tract infections are supported by extensive studies which have primarily focused on its phenolic constituents. Herein, a phenolic-free carbohydrate fraction (designated cranf1b-F2) was purified from cranberry fruit using ion exchange and size exclusion chromatography. MALDI-TOF-MS analysis revealed that the cranf1b-F2 constituents are predominantly oligosaccharides possessing various degrees of polymerisation and further structural analysis (by GC-MS and NMR) revealed mainly xyloglucan and arabinan residues. In antimicrobial assays, cranf1b-F2 (at 1.25 mg/mL concentration) reduced biofilm production by the uropathogenic Escherichia coli CFT073 strain by over 50% but did not inhibit bacterial growth. Cranf1b-F2 (ranging from 0.625 - 10 mg/mL) also inhibited biofilm formation of the non-pathogenic E. coli MG1655 strain up to 60% in a concentration-dependent manner. These results suggest that cranberry oligosaccharides, in addition to its phenolic constituents, may play a role in its preventive effects against urinary tract infections.",
author = "Jiadong Sun and Marais, {Jannie P J} and Christina Khoo and Kerry LaPlante and Vejborg, {Rebecca M} and Michael Givskov and Tim Tolker-Nielsen and Seeram, {Navindra P} and Rowley, {David C}",
year = "2015",
month = aug,
doi = "10.1016/j.jff.2015.05.016",
language = "English",
volume = "17",
pages = "235--242",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli

AU - Sun, Jiadong

AU - Marais, Jannie P J

AU - Khoo, Christina

AU - LaPlante, Kerry

AU - Vejborg, Rebecca M

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

AU - Seeram, Navindra P

AU - Rowley, David C

PY - 2015/8

Y1 - 2015/8

N2 - The preventive effects of the American cranberry (Vaccinium macrocarpon) against urinary tract infections are supported by extensive studies which have primarily focused on its phenolic constituents. Herein, a phenolic-free carbohydrate fraction (designated cranf1b-F2) was purified from cranberry fruit using ion exchange and size exclusion chromatography. MALDI-TOF-MS analysis revealed that the cranf1b-F2 constituents are predominantly oligosaccharides possessing various degrees of polymerisation and further structural analysis (by GC-MS and NMR) revealed mainly xyloglucan and arabinan residues. In antimicrobial assays, cranf1b-F2 (at 1.25 mg/mL concentration) reduced biofilm production by the uropathogenic Escherichia coli CFT073 strain by over 50% but did not inhibit bacterial growth. Cranf1b-F2 (ranging from 0.625 - 10 mg/mL) also inhibited biofilm formation of the non-pathogenic E. coli MG1655 strain up to 60% in a concentration-dependent manner. These results suggest that cranberry oligosaccharides, in addition to its phenolic constituents, may play a role in its preventive effects against urinary tract infections.

AB - The preventive effects of the American cranberry (Vaccinium macrocarpon) against urinary tract infections are supported by extensive studies which have primarily focused on its phenolic constituents. Herein, a phenolic-free carbohydrate fraction (designated cranf1b-F2) was purified from cranberry fruit using ion exchange and size exclusion chromatography. MALDI-TOF-MS analysis revealed that the cranf1b-F2 constituents are predominantly oligosaccharides possessing various degrees of polymerisation and further structural analysis (by GC-MS and NMR) revealed mainly xyloglucan and arabinan residues. In antimicrobial assays, cranf1b-F2 (at 1.25 mg/mL concentration) reduced biofilm production by the uropathogenic Escherichia coli CFT073 strain by over 50% but did not inhibit bacterial growth. Cranf1b-F2 (ranging from 0.625 - 10 mg/mL) also inhibited biofilm formation of the non-pathogenic E. coli MG1655 strain up to 60% in a concentration-dependent manner. These results suggest that cranberry oligosaccharides, in addition to its phenolic constituents, may play a role in its preventive effects against urinary tract infections.

U2 - 10.1016/j.jff.2015.05.016

DO - 10.1016/j.jff.2015.05.016

M3 - Letter

C2 - 26613004

VL - 17

SP - 235

EP - 242

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -

ID: 152934000