Cross-reactive Legionella antigens and the antibody response during infection

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cross-reactive Legionella antigens and the antibody response during infection. / Bangsborg, Jette Marie; Shand, G; Pearlman, E; Høiby, N.

In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Vol. 99, No. 9, 1991, p. 854-65.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bangsborg, JM, Shand, G, Pearlman, E & Høiby, N 1991, 'Cross-reactive Legionella antigens and the antibody response during infection', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 99, no. 9, pp. 854-65.

APA

Bangsborg, J. M., Shand, G., Pearlman, E., & Høiby, N. (1991). Cross-reactive Legionella antigens and the antibody response during infection. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, 99(9), 854-65.

Vancouver

Bangsborg JM, Shand G, Pearlman E, Høiby N. Cross-reactive Legionella antigens and the antibody response during infection. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 1991;99(9):854-65.

Author

Bangsborg, Jette Marie ; Shand, G ; Pearlman, E ; Høiby, N. / Cross-reactive Legionella antigens and the antibody response during infection. In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 1991 ; Vol. 99, No. 9. pp. 854-65.

Bibtex

@article{af382e6c79df40f5bb6fe08cf028dadf,
title = "Cross-reactive Legionella antigens and the antibody response during infection",
abstract = "In order to define cross-reactive Legionella antigens suitable for diagnostic purposes, we investigated sonicate antigens from two Legionella species, including two serogroups of L. pneumophila. The antigens were reacted with heterologous and homologous rabbit antisera in Western blot. Sera from seven patients with culture-verified L. pneumophila infection and nine patients with serologically confirmed L. micdadei infection were also investigated for reactivity with the corresponding antigens. Among the cross-reactive Legionella antigens defined, non-specific reactivity in patients' sera with the 58-kDa common antigen (CA) was noted. Specific reactions were observed with the Legionella flagellum antigen and with the macrophage infectivity potentiator (Mip) protein; with both antigens, however, the reactive sera were too few to suggest the use of a single antigen in a diagnostic test.",
keywords = "Animals, Antibody Formation, Antigens, Bacterial, Blotting, Western, Cross Reactions, Electrophoresis, Polyacrylamide Gel, Humans, Legionella, Legionnaires' Disease, Molecular Weight, Rabbits, Serotyping",
author = "Bangsborg, {Jette Marie} and G Shand and E Pearlman and N H{\o}iby",
year = "1991",
language = "English",
volume = "99",
pages = "854--65",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "9",

}

RIS

TY - JOUR

T1 - Cross-reactive Legionella antigens and the antibody response during infection

AU - Bangsborg, Jette Marie

AU - Shand, G

AU - Pearlman, E

AU - Høiby, N

PY - 1991

Y1 - 1991

N2 - In order to define cross-reactive Legionella antigens suitable for diagnostic purposes, we investigated sonicate antigens from two Legionella species, including two serogroups of L. pneumophila. The antigens were reacted with heterologous and homologous rabbit antisera in Western blot. Sera from seven patients with culture-verified L. pneumophila infection and nine patients with serologically confirmed L. micdadei infection were also investigated for reactivity with the corresponding antigens. Among the cross-reactive Legionella antigens defined, non-specific reactivity in patients' sera with the 58-kDa common antigen (CA) was noted. Specific reactions were observed with the Legionella flagellum antigen and with the macrophage infectivity potentiator (Mip) protein; with both antigens, however, the reactive sera were too few to suggest the use of a single antigen in a diagnostic test.

AB - In order to define cross-reactive Legionella antigens suitable for diagnostic purposes, we investigated sonicate antigens from two Legionella species, including two serogroups of L. pneumophila. The antigens were reacted with heterologous and homologous rabbit antisera in Western blot. Sera from seven patients with culture-verified L. pneumophila infection and nine patients with serologically confirmed L. micdadei infection were also investigated for reactivity with the corresponding antigens. Among the cross-reactive Legionella antigens defined, non-specific reactivity in patients' sera with the 58-kDa common antigen (CA) was noted. Specific reactions were observed with the Legionella flagellum antigen and with the macrophage infectivity potentiator (Mip) protein; with both antigens, however, the reactive sera were too few to suggest the use of a single antigen in a diagnostic test.

KW - Animals

KW - Antibody Formation

KW - Antigens, Bacterial

KW - Blotting, Western

KW - Cross Reactions

KW - Electrophoresis, Polyacrylamide Gel

KW - Humans

KW - Legionella

KW - Legionnaires' Disease

KW - Molecular Weight

KW - Rabbits

KW - Serotyping

M3 - Journal article

C2 - 1892639

VL - 99

SP - 854

EP - 865

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 9

ER -

ID: 40334266