Extracellular DNA as matrix component in microbial biofilms.
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Extracellular DNA as matrix component in microbial biofilms. / Chiang, Wen-Chi; Tolker-Nielsen, Tim.
Extracellular Nucleic Acids.. ed. / Y. Kikuchi; E. Rykova. Springer Publishing Company, 2010. p. 1-14.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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TY - CHAP
T1 - Extracellular DNA as matrix component in microbial biofilms.
AU - Chiang, Wen-Chi
AU - Tolker-Nielsen, Tim
PY - 2010
Y1 - 2010
N2 - Bacteria in nature primarily live in surface-associated communities commonly known as biofilms. Because bacteria in biofilms, in many cases, display tolerance to host immune systems, antibiotics, and biocides, they are often difficult or impossible to eradicate. Biofilm formation, therefore, leads to various persistent infections in humans and animals, and to a variety of complications in industry, where solid–water interfaces occur. Knowledge about the molecular mechanisms involved in biofilm formation is necessary for creating strategies to control biofilms. Recent studies have shown that extracellular DNA is an important component of the extracellular matrix of microbial biofilms. The present chapter is focussed on extracellular DNA as matrix component in biofilms formed by Pseudomonas aeruginosa as an example from the Gram-negative bacteria, and Streptococcus and Staphylococcus as examples from the Gram-positive bacteria. Besides the role of extracellular DNA in biofilm formation, the mechanisms involved in DNA release from P. aeruginosa, Streptococcus, and Staphylococcus are addressed.
AB - Bacteria in nature primarily live in surface-associated communities commonly known as biofilms. Because bacteria in biofilms, in many cases, display tolerance to host immune systems, antibiotics, and biocides, they are often difficult or impossible to eradicate. Biofilm formation, therefore, leads to various persistent infections in humans and animals, and to a variety of complications in industry, where solid–water interfaces occur. Knowledge about the molecular mechanisms involved in biofilm formation is necessary for creating strategies to control biofilms. Recent studies have shown that extracellular DNA is an important component of the extracellular matrix of microbial biofilms. The present chapter is focussed on extracellular DNA as matrix component in biofilms formed by Pseudomonas aeruginosa as an example from the Gram-negative bacteria, and Streptococcus and Staphylococcus as examples from the Gram-positive bacteria. Besides the role of extracellular DNA in biofilm formation, the mechanisms involved in DNA release from P. aeruginosa, Streptococcus, and Staphylococcus are addressed.
M3 - Book chapter
SP - 1
EP - 14
BT - Extracellular Nucleic Acids.
A2 - Kikuchi, Y.
A2 - Rykova, E.
PB - Springer Publishing Company
ER -
ID: 32314575