Forøget renal udskillelse af antibiotika kan resultere i underdosering ved sepsis
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Forøget renal udskillelse af antibiotika kan resultere i underdosering ved sepsis. / Moser, Claus; Hartvig, Tom; Schierbeck, Jens; Høiby, Niels.
In: Ugeskrift for Laeger, Vol. 178, V05150426, 2016, p. 2-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Forøget renal udskillelse af antibiotika kan resultere i underdosering ved sepsis
AU - Moser, Claus
AU - Hartvig, Tom
AU - Schierbeck, Jens
AU - Høiby, Niels
PY - 2016
Y1 - 2016
N2 - Early, relevant antibiotic treatment is of pivotal significance for survival for patients with sepsis. Recent reports reveal, that critically ill patients may need substantially higher dosing of antibiotics than the usual standards. The background is the newly described augmented renal clearance (ARC), which can be observed in critically ill patients with sepsis. ARC results in significantly reduced antibiotic concentrations in patients with sepsis and can potentially have fatal consequences. The purpose of this paper is to make medical doctors aware of the phenomenon and to compensate for the increased antibiotic clearance.
AB - Early, relevant antibiotic treatment is of pivotal significance for survival for patients with sepsis. Recent reports reveal, that critically ill patients may need substantially higher dosing of antibiotics than the usual standards. The background is the newly described augmented renal clearance (ARC), which can be observed in critically ill patients with sepsis. ARC results in significantly reduced antibiotic concentrations in patients with sepsis and can potentially have fatal consequences. The purpose of this paper is to make medical doctors aware of the phenomenon and to compensate for the increased antibiotic clearance.
KW - English Abstract
KW - Journal Article
M3 - Tidsskriftartikel
C2 - 27032308
VL - 178
SP - 2
EP - 6
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
M1 - V05150426
ER -
ID: 181026314