Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora

Research output: Contribution to journal › Journal article › Research › peer-review

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Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. / Manefield, M; Welch, M; Givskov, M; Salmond, G P; Kjelleberg, S.

In: F E M S Microbiology Letters, Vol. 205, No. 1, 2001, p. 131-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Manefield, M, Welch, M, Givskov, M, Salmond, GP & Kjelleberg, S 2001, 'Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora', F E M S Microbiology Letters, vol. 205, no. 1, pp. 131-8.

APA

Manefield, M., Welch, M., Givskov, M., Salmond, G. P., & Kjelleberg, S. (2001). Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. F E M S Microbiology Letters, 205(1), 131-8.

Vancouver

Manefield M, Welch M, Givskov M, Salmond GP, Kjelleberg S. Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. F E M S Microbiology Letters. 2001;205(1):131-8.

Author

Manefield, M ; Welch, M ; Givskov, M ; Salmond, G P ; Kjelleberg, S. / Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora. In: F E M S Microbiology Letters. 2001 ; Vol. 205, No. 1. pp. 131-8.

Bibtex

@article{96b10f4cd6204bf8b567bbc67fb2bf44,
title = "Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora",
abstract = "The plant pathogen Erwinia carotovora regulates expression of virulence factors and antibiotic production via an N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HSL) dependent quorum sensing mechanism. The marine alga Delisea pulchra produces halogenated furanones known to antagonise 3-oxo-C6-HSL activity. We have tested the effects of a halogenated furanone on the production of carbapenem, cellulase and protease in E. carotovora. Despite differences in the regulatory mechanisms controlling carbapenem and exoenzyme production each was inhibited by the algal metabolite. We present evidence to suggest that the furanone dependent inhibition of carbapenem production is a result of the disruption of the 3-oxo-C6-HSL dependent expression of the carABCDEFGH operon.",
author = "M Manefield and M Welch and M Givskov and Salmond, {G P} and S Kjelleberg",
year = "2001",
language = "English",
volume = "205",
pages = "131--8",
journal = "F E M S Microbiology Letters",
issn = "0378-1097",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Halogenated furanones from the red alga, Delisea pulchra, inhibit carbapenem antibiotic synthesis and exoenzyme virulence factor production in the phytopathogen Erwinia carotovora

AU - Manefield, M

AU - Welch, M

AU - Givskov, M

AU - Salmond, G P

AU - Kjelleberg, S

PY - 2001

Y1 - 2001

N2 - The plant pathogen Erwinia carotovora regulates expression of virulence factors and antibiotic production via an N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HSL) dependent quorum sensing mechanism. The marine alga Delisea pulchra produces halogenated furanones known to antagonise 3-oxo-C6-HSL activity. We have tested the effects of a halogenated furanone on the production of carbapenem, cellulase and protease in E. carotovora. Despite differences in the regulatory mechanisms controlling carbapenem and exoenzyme production each was inhibited by the algal metabolite. We present evidence to suggest that the furanone dependent inhibition of carbapenem production is a result of the disruption of the 3-oxo-C6-HSL dependent expression of the carABCDEFGH operon.

AB - The plant pathogen Erwinia carotovora regulates expression of virulence factors and antibiotic production via an N-3-oxohexanoyl-L-homoserine lactone (3-oxo-C6-HSL) dependent quorum sensing mechanism. The marine alga Delisea pulchra produces halogenated furanones known to antagonise 3-oxo-C6-HSL activity. We have tested the effects of a halogenated furanone on the production of carbapenem, cellulase and protease in E. carotovora. Despite differences in the regulatory mechanisms controlling carbapenem and exoenzyme production each was inhibited by the algal metabolite. We present evidence to suggest that the furanone dependent inhibition of carbapenem production is a result of the disruption of the 3-oxo-C6-HSL dependent expression of the carABCDEFGH operon.

M3 - Journal article

C2 - 11728727

VL - 205

SP - 131

EP - 138

JO - F E M S Microbiology Letters

JF - F E M S Microbiology Letters

SN - 0378-1097

IS - 1

ER -

ID: 44310336