How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1
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How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. / Rasmussen, T B; Manefield, M; Andersen, Jens Bo; Eberl, Leo; Anthoni, U; Christophersen, C; Steinberg, P; Kjelleberg, S; Givskov, M.
In: Microbiology, Vol. 146 Pt 12, 2000, p. 3237-44.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1
AU - Rasmussen, T B
AU - Manefield, M
AU - Andersen, Jens Bo
AU - Eberl, Leo
AU - Anthoni, U
AU - Christophersen, C
AU - Steinberg, P
AU - Kjelleberg, S
AU - Givskov, M
PY - 2000
Y1 - 2000
N2 - Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.
AB - Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.
KW - 4-Butyrolactone
KW - Furans
KW - Gene Expression Regulation, Bacterial
KW - Lipoproteins
KW - Luminescent Measurements
KW - Movement
KW - Peptides, Cyclic
KW - Rhodophyta
KW - Serratia
KW - Signal Transduction
KW - Transcription, Genetic
M3 - Journal article
C2 - 11101681
VL - 146 Pt 12
SP - 3237
EP - 3244
JO - Microbiology
JF - Microbiology
SN - 1350-0872
ER -
ID: 44310701