Human skin microbiota in health and disease: The cutaneous communities’ interplay in equilibrium and dysbiosis
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Human skin microbiota in health and disease : The cutaneous communities’ interplay in equilibrium and dysbiosis. / Bay, Lene; Ring, Hans Christian.
In: APMIS, Vol. 130, No. 12, 2022, p. 706-718.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Human skin microbiota in health and disease
T2 - The cutaneous communities’ interplay in equilibrium and dysbiosis
AU - Bay, Lene
AU - Ring, Hans Christian
N1 - Publisher Copyright: © 2021 Scandinavian Societies for Medical Microbiology and Pathology.
PY - 2022
Y1 - 2022
N2 - Cutaneous microbial composition is driven by the microenvironment of the skin, as well as by internal and external factors. Local changes in the microenvironment can affect the configuration of the community, which may lead toward an imbalance of microbiota. Alterations in the microbial profile are common in both inflammatory skin diseases and chronic infections. A shift in balance within the microbiota, toward limited variation and a greater abundance of specific pathogens, may further worsen the pathogenicity of the diseases. These alterations may be prevented by topical treatment of probiotic solutions stimulating a balanced multispecies community. Compositional variations may further constitute potential biomarkers to predict flares or monitor efficacy during therapy. New approaches such as machine learning may contribute to this prediction of microbial alterations prior to the development of chronic infections and flares. This review provides insight into the composition and distribution of a healthy community of microorganisms in the skin and draws parallels with the community in chronic infections and chronic inflammatory skin diseases such acne vulgaris and Hidradenitis Suppurativa. We discuss the potential role of specific species in the pathogenesis and the possible prevention of disease exacerbation.
AB - Cutaneous microbial composition is driven by the microenvironment of the skin, as well as by internal and external factors. Local changes in the microenvironment can affect the configuration of the community, which may lead toward an imbalance of microbiota. Alterations in the microbial profile are common in both inflammatory skin diseases and chronic infections. A shift in balance within the microbiota, toward limited variation and a greater abundance of specific pathogens, may further worsen the pathogenicity of the diseases. These alterations may be prevented by topical treatment of probiotic solutions stimulating a balanced multispecies community. Compositional variations may further constitute potential biomarkers to predict flares or monitor efficacy during therapy. New approaches such as machine learning may contribute to this prediction of microbial alterations prior to the development of chronic infections and flares. This review provides insight into the composition and distribution of a healthy community of microorganisms in the skin and draws parallels with the community in chronic infections and chronic inflammatory skin diseases such acne vulgaris and Hidradenitis Suppurativa. We discuss the potential role of specific species in the pathogenesis and the possible prevention of disease exacerbation.
U2 - 10.1111/apm.13201
DO - 10.1111/apm.13201
M3 - Review
C2 - 34919288
AN - SCOPUS:85122156741
VL - 130
SP - 706
EP - 718
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 12
ER -
ID: 289392936