TY - JOUR

T1 - Immune Responses to Pseudomonas aeruginosa Biofilm Infections

AU - Moser, Claus

AU - Jensen, Peter Østrup

AU - Thomsen, Kim

AU - Kolpen, Mette

AU - Rybtke, Morten

AU - Lauland, Anne Sofie

AU - Trøstrup, Hannah

AU - Tolker-Nielsen, Tim

PY - 2021

Y1 - 2021

N2 - Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these infections the bacteria congregate in biofilms and cannot be eradicated by standard antibiotic treatment or host immune responses. The persistent biofilms induce a hyper inflammatory state that results in collateral damage of the adjacent host tissue. The host fails to eradicate the biofilm infection, resulting in hindered remodeling and healing. In the present review we describe our current understanding of innate and adaptive immune responses elicited by P. aeruginosa biofilms in cystic fibrosis lung infections and chronic wounds. This includes the mechanisms that are involved in the activation of the immune responses, as well as the effector functions, the antimicrobial components and the associated tissue destruction. The mechanisms by which the biofilms evade immune responses, and potential treatment targets of the immune response are also discussed.

AB - Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these infections the bacteria congregate in biofilms and cannot be eradicated by standard antibiotic treatment or host immune responses. The persistent biofilms induce a hyper inflammatory state that results in collateral damage of the adjacent host tissue. The host fails to eradicate the biofilm infection, resulting in hindered remodeling and healing. In the present review we describe our current understanding of innate and adaptive immune responses elicited by P. aeruginosa biofilms in cystic fibrosis lung infections and chronic wounds. This includes the mechanisms that are involved in the activation of the immune responses, as well as the effector functions, the antimicrobial components and the associated tissue destruction. The mechanisms by which the biofilms evade immune responses, and potential treatment targets of the immune response are also discussed.

KW - adaptive immune response

KW - biofilm infections

KW - innate immune response

KW - novel treatment possibilities

KW - Pseudomonas aeruginosa

U2 - 10.3389/fimmu.2021.625597

DO - 10.3389/fimmu.2021.625597

M3 - Review

C2 - 33692800

AN - SCOPUS:85102237924

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 625597

ER -