Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response

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Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. / Moser, C; Jensen, P O; Kobayashi, O; Hougen, Hans Petter; Song, Z; Rygaard, J; Kharazmi, A; Høiby, Niels.

In: Clinical and Experimental Immunology, Vol. 127, No. 2, 01.02.2002, p. 206-213.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Moser, C, Jensen, PO, Kobayashi, O, Hougen, HP, Song, Z, Rygaard, J, Kharazmi, A & Høiby, N 2002, 'Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response', Clinical and Experimental Immunology, vol. 127, no. 2, pp. 206-213.

APA

Moser, C., Jensen, P. O., Kobayashi, O., Hougen, H. P., Song, Z., Rygaard, J., Kharazmi, A., & Høiby, N. (2002). Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. Clinical and Experimental Immunology, 127(2), 206-213.

Vancouver

Moser C, Jensen PO, Kobayashi O, Hougen HP, Song Z, Rygaard J et al. Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. Clinical and Experimental Immunology. 2002 Feb 1;127(2):206-213.

Author

Moser, C ; Jensen, P O ; Kobayashi, O ; Hougen, Hans Petter ; Song, Z ; Rygaard, J ; Kharazmi, A ; Høiby, Niels. / Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. In: Clinical and Experimental Immunology. 2002 ; Vol. 127, No. 2. pp. 206-213.

Bibtex

@article{9528cce074c511dbbee902004c4f4f50,
title = "Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response",
abstract = "Repeated challenge with antigen is involved in the pathogenesis of a variety of pulmonary diseases. Patients with cystic fibrosis (CF) experience recurrent pulmonary colonization with Pseudomonas aeruginosa before establishment of chronic lung infection. To mimic recurrent lung infections in CF patients, the lungs of susceptible BALB/c mice were re-infected with P. aeruginosa 14 days after the initial infection. Singly-infected BALB/c mice, as well as non-infected mice, were used as controls. Decreased mortality and milder lung inflammation in re-infected BALB/c mice, as well as a tendency for improved clearance of bacteria, was observed when compared with singly-infected mice. The improved outcome in re-infected mice correlated with changes in CD4 cell numbers. Surface expression of LFA-1 on pulmonary CD4 cells was increased in re-infected compared with singly-infected mice. Moreover, resistance to re-infection was paralleled by a shift towards a Th1-dominated response and increased IL-12 production. No significant increase in serum IgG was observed in the re-infected mice. In conclusion, these results indicate a protective role for a Th1-dominated response, independent of antibody production, in chronic P. aeruginosa lung infection in CF.",
author = "C Moser and Jensen, {P O} and O Kobayashi and Hougen, {Hans Petter} and Z Song and J Rygaard and A Kharazmi and Niels H{\o}iby",
year = "2002",
month = feb,
day = "1",
language = "English",
volume = "127",
pages = "206--213",
journal = "Clinical and Experimental Immunology, Supplement",
issn = "0964-2536",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response

AU - Moser, C

AU - Jensen, P O

AU - Kobayashi, O

AU - Hougen, Hans Petter

AU - Song, Z

AU - Rygaard, J

AU - Kharazmi, A

AU - Høiby, Niels

PY - 2002/2/1

Y1 - 2002/2/1

N2 - Repeated challenge with antigen is involved in the pathogenesis of a variety of pulmonary diseases. Patients with cystic fibrosis (CF) experience recurrent pulmonary colonization with Pseudomonas aeruginosa before establishment of chronic lung infection. To mimic recurrent lung infections in CF patients, the lungs of susceptible BALB/c mice were re-infected with P. aeruginosa 14 days after the initial infection. Singly-infected BALB/c mice, as well as non-infected mice, were used as controls. Decreased mortality and milder lung inflammation in re-infected BALB/c mice, as well as a tendency for improved clearance of bacteria, was observed when compared with singly-infected mice. The improved outcome in re-infected mice correlated with changes in CD4 cell numbers. Surface expression of LFA-1 on pulmonary CD4 cells was increased in re-infected compared with singly-infected mice. Moreover, resistance to re-infection was paralleled by a shift towards a Th1-dominated response and increased IL-12 production. No significant increase in serum IgG was observed in the re-infected mice. In conclusion, these results indicate a protective role for a Th1-dominated response, independent of antibody production, in chronic P. aeruginosa lung infection in CF.

AB - Repeated challenge with antigen is involved in the pathogenesis of a variety of pulmonary diseases. Patients with cystic fibrosis (CF) experience recurrent pulmonary colonization with Pseudomonas aeruginosa before establishment of chronic lung infection. To mimic recurrent lung infections in CF patients, the lungs of susceptible BALB/c mice were re-infected with P. aeruginosa 14 days after the initial infection. Singly-infected BALB/c mice, as well as non-infected mice, were used as controls. Decreased mortality and milder lung inflammation in re-infected BALB/c mice, as well as a tendency for improved clearance of bacteria, was observed when compared with singly-infected mice. The improved outcome in re-infected mice correlated with changes in CD4 cell numbers. Surface expression of LFA-1 on pulmonary CD4 cells was increased in re-infected compared with singly-infected mice. Moreover, resistance to re-infection was paralleled by a shift towards a Th1-dominated response and increased IL-12 production. No significant increase in serum IgG was observed in the re-infected mice. In conclusion, these results indicate a protective role for a Th1-dominated response, independent of antibody production, in chronic P. aeruginosa lung infection in CF.

M3 - Journal article

VL - 127

SP - 206

EP - 213

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

SN - 0964-2536

IS - 2

ER -

ID: 134554