Lipocalin 2 is protective against E. coli pneumonia
Research output: Contribution to journal › Journal article › Research › peer-review
Lipocalin 2 is a bacteriostatic protein that binds the siderophore enterobactin, an iron-chelating molecule produced by Escherichia coli (E. coli) that is required for bacterial growth. Infection of the lungs by E. coli is rare despite a frequent exposure to this commensal bacterium. Lipocalin 2 is an effector molecule of the innate immune system and could therefore play a role in hindering growth of E. coli in the lungs.
| Original language | English |
|---|---|
| Journal | Respiratory research |
| Volume | 11 |
| Pages (from-to) | 96 |
| ISSN | 1465-9921 |
| DOIs | |
| Publication status | Published - 2010 |
- Acute-Phase Proteins, Animals, Blotting, Western, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Female, Ferrichrome, Immunity, Innate, Immunohistochemistry, Lipocalins, Lung, Matrix Metalloproteinase 9, Mice, Mice, Inbred C57BL, Mice, Knockout, Oncogene Proteins, Pneumocytes, Pneumonia, Bacterial, Respiratory Mucosa, Siderophores, Time Factors
Research areas
ID: 107122370