Microbial Primer: In vivo biofilm
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Microbial Primer : In vivo biofilm. / Rumbaugh, Kendra P.; Bjarnsholt, Thomas.
In: Microbiology (United Kingdom), Vol. 169, No. 12, 001407, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Microbial Primer
T2 - In vivo biofilm
AU - Rumbaugh, Kendra P.
AU - Bjarnsholt, Thomas
N1 - Publisher Copyright: © 2023 The Authors.
PY - 2023
Y1 - 2023
N2 - In this primer on biofilms and their role in infections, we trace the historical roots of microbial understanding from Van Leeuwenhoek’s observations to Bill Costerton’s groundbreaking work, which solidified biofilms' significance in infections. In vivo biofilm research, investigating patient samples and utilizing diverse host models, has yielded invaluable insights into these complex microbial communities. However, it comes with several challenges, particularly regarding replicating biofilm infections accurately in the laboratory. In vivo biofilm analyses involve various techniques, revealing biofilm architecture, composition, and behaviour, while gaps in knowledge persist regarding infection initiation and source, diversity, and the Infectious Microenvironment (IME). Ultimately, the study of biofilms in infections remains a dynamic and evolving field poised to transform our approach to combat biofilm-associated diseases.
AB - In this primer on biofilms and their role in infections, we trace the historical roots of microbial understanding from Van Leeuwenhoek’s observations to Bill Costerton’s groundbreaking work, which solidified biofilms' significance in infections. In vivo biofilm research, investigating patient samples and utilizing diverse host models, has yielded invaluable insights into these complex microbial communities. However, it comes with several challenges, particularly regarding replicating biofilm infections accurately in the laboratory. In vivo biofilm analyses involve various techniques, revealing biofilm architecture, composition, and behaviour, while gaps in knowledge persist regarding infection initiation and source, diversity, and the Infectious Microenvironment (IME). Ultimately, the study of biofilms in infections remains a dynamic and evolving field poised to transform our approach to combat biofilm-associated diseases.
KW - animal model
KW - biofilm
KW - in vivo
U2 - 10.1099/mic.0.001407
DO - 10.1099/mic.0.001407
M3 - Journal article
C2 - 38050845
AN - SCOPUS:85178850844
VL - 169
JO - Microbiology
JF - Microbiology
SN - 1350-0872
IS - 12
M1 - 001407
ER -
ID: 377835056