Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer. / Vejlgaard, Maja; Maibom, Sophia L.; Joensen, Ulla N.; Moser, Claus; Røder, Andreas.

In: Urology, Vol. 183, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Vejlgaard, M, Maibom, SL, Joensen, UN, Moser, C & Røder, A 2024, 'Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer', Urology, vol. 183. https://doi.org/10.1016/j.urology.2023.09.007

APA

Vejlgaard, M., Maibom, S. L., Joensen, U. N., Moser, C., & Røder, A. (2024). Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer. Urology, 183. https://doi.org/10.1016/j.urology.2023.09.007

Vancouver

Vejlgaard M, Maibom SL, Joensen UN, Moser C, Røder A. Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer. Urology. 2024;183. https://doi.org/10.1016/j.urology.2023.09.007

Author

Vejlgaard, Maja ; Maibom, Sophia L. ; Joensen, Ulla N. ; Moser, Claus ; Røder, Andreas. / Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer. In: Urology. 2024 ; Vol. 183.

Bibtex

@article{f9f594edcced4f598ad9c5015a71487b,
title = "Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer",
abstract = "Objective: To report microbial pathogens detected at infection-related readmissions, including their susceptibility to antimicrobials. Materials and Methods: A retrospective review of 785 patients who underwent radical cystectomy for bladder cancer at a tertiary center in Denmark between 2009 and 2019. All patients received prophylactic cefuroxime preoperatively and pivmecillinam at stent- or catheter removal. Data were collected through the national medical records and microbiology database. The primary outcome was readmission rate and pathogens detected at infection-related readmissions. Univariable and multivariable regression analyses were carried out to identify risk factors of readmission. Results: Within 90 days of surgery, 225 (29%) patients experienced at least one infection-related readmission. The most common pathogen identified was Enterococcus spp (24% of all positive samples). In blood cultures, the most dominant species were Escherichia coli (29%) and Staphylococcus spp (26%). Due to the heterogeneity in microbial species identified, more than one-third of the bacteria where mecillinam was tested showed resistance. Most isolates were susceptible to piperacillin + tazobactam. Orthotopic neobladder and continent cutaneous reservoir were associated with the highest risk of infection-related readmission compared to ileal conduit (odds ratios 2.78 [95%CI 1.66;4.65] and 3.08 [95%CI 1.58;5.98], respectively). Patients with diabetes had an increased risk of infection-related readmission compared to patients without diabetes (odds ratio 1.67 [95%CI 1.02;2.73]). Conclusion: Nearly one-third of all patients experienced at least one postoperative infection-related readmission with a wide range of microbial etiologies. Generalizability of our results is uncertain, but the data can be used to plan interventional trials of antibiotic prophylaxis.",
author = "Maja Vejlgaard and Maibom, {Sophia L.} and Joensen, {Ulla N.} and Claus Moser and Andreas R{\o}der",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2024",
doi = "10.1016/j.urology.2023.09.007",
language = "English",
volume = "183",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Microbial Trends in Infection-related Readmissions Following Radical Cystectomy for Bladder Cancer

AU - Vejlgaard, Maja

AU - Maibom, Sophia L.

AU - Joensen, Ulla N.

AU - Moser, Claus

AU - Røder, Andreas

N1 - Publisher Copyright: © 2023 The Authors

PY - 2024

Y1 - 2024

N2 - Objective: To report microbial pathogens detected at infection-related readmissions, including their susceptibility to antimicrobials. Materials and Methods: A retrospective review of 785 patients who underwent radical cystectomy for bladder cancer at a tertiary center in Denmark between 2009 and 2019. All patients received prophylactic cefuroxime preoperatively and pivmecillinam at stent- or catheter removal. Data were collected through the national medical records and microbiology database. The primary outcome was readmission rate and pathogens detected at infection-related readmissions. Univariable and multivariable regression analyses were carried out to identify risk factors of readmission. Results: Within 90 days of surgery, 225 (29%) patients experienced at least one infection-related readmission. The most common pathogen identified was Enterococcus spp (24% of all positive samples). In blood cultures, the most dominant species were Escherichia coli (29%) and Staphylococcus spp (26%). Due to the heterogeneity in microbial species identified, more than one-third of the bacteria where mecillinam was tested showed resistance. Most isolates were susceptible to piperacillin + tazobactam. Orthotopic neobladder and continent cutaneous reservoir were associated with the highest risk of infection-related readmission compared to ileal conduit (odds ratios 2.78 [95%CI 1.66;4.65] and 3.08 [95%CI 1.58;5.98], respectively). Patients with diabetes had an increased risk of infection-related readmission compared to patients without diabetes (odds ratio 1.67 [95%CI 1.02;2.73]). Conclusion: Nearly one-third of all patients experienced at least one postoperative infection-related readmission with a wide range of microbial etiologies. Generalizability of our results is uncertain, but the data can be used to plan interventional trials of antibiotic prophylaxis.

AB - Objective: To report microbial pathogens detected at infection-related readmissions, including their susceptibility to antimicrobials. Materials and Methods: A retrospective review of 785 patients who underwent radical cystectomy for bladder cancer at a tertiary center in Denmark between 2009 and 2019. All patients received prophylactic cefuroxime preoperatively and pivmecillinam at stent- or catheter removal. Data were collected through the national medical records and microbiology database. The primary outcome was readmission rate and pathogens detected at infection-related readmissions. Univariable and multivariable regression analyses were carried out to identify risk factors of readmission. Results: Within 90 days of surgery, 225 (29%) patients experienced at least one infection-related readmission. The most common pathogen identified was Enterococcus spp (24% of all positive samples). In blood cultures, the most dominant species were Escherichia coli (29%) and Staphylococcus spp (26%). Due to the heterogeneity in microbial species identified, more than one-third of the bacteria where mecillinam was tested showed resistance. Most isolates were susceptible to piperacillin + tazobactam. Orthotopic neobladder and continent cutaneous reservoir were associated with the highest risk of infection-related readmission compared to ileal conduit (odds ratios 2.78 [95%CI 1.66;4.65] and 3.08 [95%CI 1.58;5.98], respectively). Patients with diabetes had an increased risk of infection-related readmission compared to patients without diabetes (odds ratio 1.67 [95%CI 1.02;2.73]). Conclusion: Nearly one-third of all patients experienced at least one postoperative infection-related readmission with a wide range of microbial etiologies. Generalizability of our results is uncertain, but the data can be used to plan interventional trials of antibiotic prophylaxis.

U2 - 10.1016/j.urology.2023.09.007

DO - 10.1016/j.urology.2023.09.007

M3 - Journal article

C2 - 37742848

AN - SCOPUS:85174204247

VL - 183

JO - Urology

JF - Urology

SN - 0090-4295

ER -

ID: 373887243