Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. / Marvig, Rasmus Lykke; Søndergaard, Mette S R; Damkiær, Søren; Høiby, Niels; Johansen, Helle Krogh; Molin, Søren; Jelsbak, Lars.

In: Antimicrobial Agents and Chemotherapy, Vol. 56, No. 8, 08.2012, p. 4519-4521.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Marvig, RL, Søndergaard, MSR, Damkiær, S, Høiby, N, Johansen, HK, Molin, S & Jelsbak, L 2012, 'Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa', Antimicrobial Agents and Chemotherapy, vol. 56, no. 8, pp. 4519-4521. https://doi.org/10.1128/AAC.00630-12

APA

Marvig, R. L., Søndergaard, M. S. R., Damkiær, S., Høiby, N., Johansen, H. K., Molin, S., & Jelsbak, L. (2012). Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 56(8), 4519-4521. https://doi.org/10.1128/AAC.00630-12

Vancouver

Marvig RL, Søndergaard MSR, Damkiær S, Høiby N, Johansen HK, Molin S et al. Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 2012 Aug;56(8):4519-4521. https://doi.org/10.1128/AAC.00630-12

Author

Marvig, Rasmus Lykke ; Søndergaard, Mette S R ; Damkiær, Søren ; Høiby, Niels ; Johansen, Helle Krogh ; Molin, Søren ; Jelsbak, Lars. / Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. In: Antimicrobial Agents and Chemotherapy. 2012 ; Vol. 56, No. 8. pp. 4519-4521.

Bibtex

@article{24409f6461a6415990c326325ed4bdf9,
title = "Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa",
abstract = "The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.",
keywords = "Anti-Bacterial Agents, Azithromycin, Cystic Fibrosis, Drug Resistance, Bacterial, Humans, Microbial Sensitivity Tests, Mutation, Point Mutation, Pseudomonas Infections, Pseudomonas aeruginosa, RNA, Bacterial, RNA, Ribosomal, 23S",
author = "Marvig, {Rasmus Lykke} and S{\o}ndergaard, {Mette S R} and S{\o}ren Damki{\ae}r and Niels H{\o}iby and Johansen, {Helle Krogh} and S{\o}ren Molin and Lars Jelsbak",
year = "2012",
month = aug,
doi = "10.1128/AAC.00630-12",
language = "English",
volume = "56",
pages = "4519--4521",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "8",

}

RIS

TY - JOUR

T1 - Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

AU - Marvig, Rasmus Lykke

AU - Søndergaard, Mette S R

AU - Damkiær, Søren

AU - Høiby, Niels

AU - Johansen, Helle Krogh

AU - Molin, Søren

AU - Jelsbak, Lars

PY - 2012/8

Y1 - 2012/8

N2 - The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

AB - The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

KW - Anti-Bacterial Agents

KW - Azithromycin

KW - Cystic Fibrosis

KW - Drug Resistance, Bacterial

KW - Humans

KW - Microbial Sensitivity Tests

KW - Mutation

KW - Point Mutation

KW - Pseudomonas Infections

KW - Pseudomonas aeruginosa

KW - RNA, Bacterial

KW - RNA, Ribosomal, 23S

U2 - 10.1128/AAC.00630-12

DO - 10.1128/AAC.00630-12

M3 - Journal article

C2 - 22644032

VL - 56

SP - 4519

EP - 4521

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 8

ER -

ID: 49278360