Novel and future treatment strategies
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Novel and future treatment strategies. / Alhede, Morten; Jakobsen, Tim Holm; Givskov, Michael.
Biofilm Infections. Springer, 2011. p. 231-249.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Novel and future treatment strategies
AU - Alhede, Morten
AU - Jakobsen, Tim Holm
AU - Givskov, Michael
PY - 2011/12/1
Y1 - 2011/12/1
N2 - The biofilm mode of life is by many scientists acknowledged as a successful, bacterial survival strategy in hostile environments. When bacteria invade their hosts, they encounter harsh conditions such as low levels of iron, oxidative stress, macerating enzymes, phagocytic cells, and host-derived as well as administered antimicrobials. Experimental evidence has accumulated over the years showing that biofilms tolerate antimicrobial properties of the immune system and antibiotics. This multifaceted tolerance relies to a certain extend on general resistance mechanisms including efflux pumps and enzymatic modifications in addition to innate tolerances offered by integral structure-functions of the biofilm.
AB - The biofilm mode of life is by many scientists acknowledged as a successful, bacterial survival strategy in hostile environments. When bacteria invade their hosts, they encounter harsh conditions such as low levels of iron, oxidative stress, macerating enzymes, phagocytic cells, and host-derived as well as administered antimicrobials. Experimental evidence has accumulated over the years showing that biofilms tolerate antimicrobial properties of the immune system and antibiotics. This multifaceted tolerance relies to a certain extend on general resistance mechanisms including efflux pumps and enzymatic modifications in addition to innate tolerances offered by integral structure-functions of the biofilm.
UR - http://www.scopus.com/inward/record.url?scp=84855884107&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-6084-9_14
DO - 10.1007/978-1-4419-6084-9_14
M3 - Book chapter
AN - SCOPUS:84855884107
SN - 9781441960832
SP - 231
EP - 249
BT - Biofilm Infections
PB - Springer
ER -
ID: 201670826