Nye retningslinjer for antibiotikadosering til patienter med nedsat nyrefunktion og patienter i haemodialyse

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Dosing of antibiotics in patients with renal insufficiency has almost exclusively been based on pharmacokinetic (PK) parameters, whereas the different pharmacodynamic (PD) parameters of antibiotics have only been sparsely considered. This is not appropriate since antibiotics can be divided into two distinct groups: 1) Time-dependent and 2) Concentration (or total dose) dependent killing of bacteria. In this document revised recommendations based on PK/PD parameters are suggested.
Udgivelsesdato: 2008-Feb-18
Translated title of the contributionNew recommendations for antibiotic dosing in patients with renal insufficiency and in patients undergoing haemodialysis
Original languageDanish
JournalUgeskrift for læger
Volume170
Issue number8
Pages (from-to)629-32
Number of pages3
ISSN0041-5782
Publication statusPublished - 2008

Bibliographical note

Keywords: Anti-Bacterial Agents; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Renal Dialysis; Renal Insufficiency; Time Factors

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