Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms. / Hengzhuang, Wang; Wu, Hong; Ciofu, Oana; Song, Zhijun; Høiby, Niels.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 9, 01.09.2011, p. 4469-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hengzhuang, W, Wu, H, Ciofu, O, Song, Z & Høiby, N 2011, 'Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms', Antimicrobial Agents and Chemotherapy, vol. 55, no. 9, pp. 4469-74. https://doi.org/10.1128/AAC.00126-11, https://doi.org/10.1128/AAC.00126-11

APA

Hengzhuang, W., Wu, H., Ciofu, O., Song, Z., & Høiby, N. (2011). Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms. Antimicrobial Agents and Chemotherapy, 55(9), 4469-74. https://doi.org/10.1128/AAC.00126-11, https://doi.org/10.1128/AAC.00126-11

Vancouver

Hengzhuang W, Wu H, Ciofu O, Song Z, Høiby N. Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms. Antimicrobial Agents and Chemotherapy. 2011 Sep 1;55(9):4469-74. https://doi.org/10.1128/AAC.00126-11, https://doi.org/10.1128/AAC.00126-11

Author

Hengzhuang, Wang ; Wu, Hong ; Ciofu, Oana ; Song, Zhijun ; Høiby, Niels. / Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms. In: Antimicrobial Agents and Chemotherapy. 2011 ; Vol. 55, No. 9. pp. 4469-74.

Bibtex

@article{1a78ad1c3cb04c8486e36ea87aa9ab89,
title = "Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms",
abstract = "The time course activity of Colistin and Imipenem on mucoid and non-mucoid biofilm-growing P. aeruginosa showed that compared with planktonic bacteria, the kinetics of Colistin and Imipenem retained the concentration- and time-dependent killings, respectively but higher doses of antibiotics and for longer periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate compared to non-mucoid biofilms.",
author = "Wang Hengzhuang and Hong Wu and Oana Ciofu and Zhijun Song and Niels H{\o}iby",
year = "2011",
month = sep,
day = "1",
doi = "10.1128/AAC.00126-11",
language = "English",
volume = "55",
pages = "4469--74",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",

}

RIS

TY - JOUR

T1 - Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

AU - Hengzhuang, Wang

AU - Wu, Hong

AU - Ciofu, Oana

AU - Song, Zhijun

AU - Høiby, Niels

PY - 2011/9/1

Y1 - 2011/9/1

N2 - The time course activity of Colistin and Imipenem on mucoid and non-mucoid biofilm-growing P. aeruginosa showed that compared with planktonic bacteria, the kinetics of Colistin and Imipenem retained the concentration- and time-dependent killings, respectively but higher doses of antibiotics and for longer periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate compared to non-mucoid biofilms.

AB - The time course activity of Colistin and Imipenem on mucoid and non-mucoid biofilm-growing P. aeruginosa showed that compared with planktonic bacteria, the kinetics of Colistin and Imipenem retained the concentration- and time-dependent killings, respectively but higher doses of antibiotics and for longer periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate compared to non-mucoid biofilms.

U2 - 10.1128/AAC.00126-11

DO - 10.1128/AAC.00126-11

M3 - Journal article

C2 - 21670181

VL - 55

SP - 4469

EP - 4474

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -

ID: 33842494