Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms. / Hengzhuang, Wang; Wu, Hong; Ciofu, Oana; Song, Zhijun; Høiby, Niels; Wang, Hengzhuang.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 9, 09.2011, p. 4469-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hengzhuang, W, Wu, H, Ciofu, O, Song, Z, Høiby, N & Wang, H 2011, 'Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms', Antimicrobial Agents and Chemotherapy, vol. 55, no. 9, pp. 4469-74. https://doi.org/10.1128/AAC.00126-11

APA

Hengzhuang, W., Wu, H., Ciofu, O., Song, Z., Høiby, N., & Wang, H. (2011). Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 55(9), 4469-74. https://doi.org/10.1128/AAC.00126-11

Vancouver

Hengzhuang W, Wu H, Ciofu O, Song Z, Høiby N, Wang H. Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy. 2011 Sep;55(9):4469-74. https://doi.org/10.1128/AAC.00126-11

Author

Hengzhuang, Wang ; Wu, Hong ; Ciofu, Oana ; Song, Zhijun ; Høiby, Niels ; Wang, Hengzhuang. / Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms. In: Antimicrobial Agents and Chemotherapy. 2011 ; Vol. 55, No. 9. pp. 4469-74.

Bibtex

@article{979b2d23b04141e38ced3e087a8a3a00,
title = "Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms",
abstract = "The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.",
keywords = "Anti-Bacterial Agents, Biofilms, Colistin, Imipenem, Pseudomonas aeruginosa",
author = "Wang Hengzhuang and Hong Wu and Oana Ciofu and Zhijun Song and Niels H{\o}iby and Hengzhuang Wang",
year = "2011",
month = sep,
doi = "10.1128/AAC.00126-11",
language = "English",
volume = "55",
pages = "4469--74",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",

}

RIS

TY - JOUR

T1 - Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

AU - Hengzhuang, Wang

AU - Wu, Hong

AU - Ciofu, Oana

AU - Song, Zhijun

AU - Høiby, Niels

AU - Wang, Hengzhuang

PY - 2011/9

Y1 - 2011/9

N2 - The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

AB - The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.

KW - Anti-Bacterial Agents

KW - Biofilms

KW - Colistin

KW - Imipenem

KW - Pseudomonas aeruginosa

U2 - 10.1128/AAC.00126-11

DO - 10.1128/AAC.00126-11

M3 - Journal article

C2 - 21670181

VL - 55

SP - 4469

EP - 4474

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 9

ER -

ID: 113179926