Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. / Hentzer, Morten; Givskov, Michael.

In: Journal of Clinical Investigation, Vol. 112, No. 9, 2003, p. 1300-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hentzer, M & Givskov, M 2003, 'Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections', Journal of Clinical Investigation, vol. 112, no. 9, pp. 1300-7. https://doi.org/10.1172/JCI20074

APA

Hentzer, M., & Givskov, M. (2003). Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. Journal of Clinical Investigation, 112(9), 1300-7. https://doi.org/10.1172/JCI20074

Vancouver

Hentzer M, Givskov M. Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. Journal of Clinical Investigation. 2003;112(9):1300-7. https://doi.org/10.1172/JCI20074

Author

Hentzer, Morten ; Givskov, Michael. / Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. In: Journal of Clinical Investigation. 2003 ; Vol. 112, No. 9. pp. 1300-7.

Bibtex

@article{03c62210fcf011ddb219000ea68e967b,
title = "Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections",
abstract = "Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.",
author = "Morten Hentzer and Michael Givskov",
note = "Keywords: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Bacterial Infections; Biofilms; Chronic Disease; Furans; Humans; Signal Transduction",
year = "2003",
doi = "10.1172/JCI20074",
language = "English",
volume = "112",
pages = "1300--7",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "American Society for Clinical Investigation",
number = "9",

}

RIS

TY - JOUR

T1 - Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

AU - Hentzer, Morten

AU - Givskov, Michael

N1 - Keywords: 4-Butyrolactone; Animals; Anti-Bacterial Agents; Bacterial Infections; Biofilms; Chronic Disease; Furans; Humans; Signal Transduction

PY - 2003

Y1 - 2003

N2 - Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.

AB - Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. The discovery of bacterial-communication systems (quorum-sensing systems), which orchestrate important temporal events during the infection process, has afforded a novel opportunity to ameliorate bacterial infection by means other than growth inhibition. Compounds able to override bacterial signaling are present in nature. Herein we discuss the known signaling mechanisms and potential antipathogenic drugs that specifically target quorum-sensing systems in a manner unlikely to pose a selective pressure for the development of resistant mutants.

U2 - 10.1172/JCI20074

DO - 10.1172/JCI20074

M3 - Journal article

C2 - 14597754

VL - 112

SP - 1300

EP - 1307

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 9

ER -

ID: 10615223