Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis. / Solli, Camilla N.; Bock, Magnus; Kaur, Kamal P.; Kristensen, Jonas H.; Greibe, Eva; Hansen, Henrik P.; Boesby, Lene; Borg, Rikke; Chaudry, Mavish; Hoffmann-Lücke, Elke; Moser, Claus; Falkentoft, Alexander C.; Fosbøl, Emil; Østergaard, Lauge; Torp-Pedersen, Christian; Bundgaard, Henning; Iversen, Kasper; Bruun, Niels E.

In: Journal of Antimicrobial Chemotherapy, Vol. 78, No. 3, 2023, p. 724-731.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Solli, CN, Bock, M, Kaur, KP, Kristensen, JH, Greibe, E, Hansen, HP, Boesby, L, Borg, R, Chaudry, M, Hoffmann-Lücke, E, Moser, C, Falkentoft, AC, Fosbøl, E, Østergaard, L, Torp-Pedersen, C, Bundgaard, H, Iversen, K & Bruun, NE 2023, 'Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis', Journal of Antimicrobial Chemotherapy, vol. 78, no. 3, pp. 724-731. https://doi.org/10.1093/jac/dkad002

APA

Solli, C. N., Bock, M., Kaur, K. P., Kristensen, J. H., Greibe, E., Hansen, H. P., Boesby, L., Borg, R., Chaudry, M., Hoffmann-Lücke, E., Moser, C., Falkentoft, A. C., Fosbøl, E., Østergaard, L., Torp-Pedersen, C., Bundgaard, H., Iversen, K., & Bruun, N. E. (2023). Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis. Journal of Antimicrobial Chemotherapy, 78(3), 724-731. https://doi.org/10.1093/jac/dkad002

Vancouver

Solli CN, Bock M, Kaur KP, Kristensen JH, Greibe E, Hansen HP et al. Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis. Journal of Antimicrobial Chemotherapy. 2023;78(3):724-731. https://doi.org/10.1093/jac/dkad002

Author

Solli, Camilla N. ; Bock, Magnus ; Kaur, Kamal P. ; Kristensen, Jonas H. ; Greibe, Eva ; Hansen, Henrik P. ; Boesby, Lene ; Borg, Rikke ; Chaudry, Mavish ; Hoffmann-Lücke, Elke ; Moser, Claus ; Falkentoft, Alexander C. ; Fosbøl, Emil ; Østergaard, Lauge ; Torp-Pedersen, Christian ; Bundgaard, Henning ; Iversen, Kasper ; Bruun, Niels E. / Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis. In: Journal of Antimicrobial Chemotherapy. 2023 ; Vol. 78, No. 3. pp. 724-731.

Bibtex

@article{9bc9f73f2fda4f459f5527ad4eceea2b,
title = "Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis",
abstract = "Objectives: In the randomized controlled trial PANTHEM, the prophylactic effect of oral amoxicillin or clindamycin is investigated in patients receiving chronic haemodialysis (HD). However, data on plasma concentrations of these antibiotics during HD are sparse. This study aims to determine if the plasma concentration of amoxicillin and clindamycin is sufficient during HD after oral administration of amoxicillin and clindamycin at three different time intervals prior to the HD procedure. Methods: Adult patients receiving chronic HD were investigated twice with an interval of at least 7 days starting with either a tablet of 500/125 mg amoxicillin/clavulanic acid or a tablet of 600 mg clindamycin. Patients were randomized to take the antibiotics either 30, 60 or 120 min prior to the HD procedure. Plasma antibiotic concentrations were measured at start, midway and at the end of HD. A lower threshold was set at 2.0 mg/L for amoxicillin and at 1.0 mg/L for clindamycin. In addition, a population pharmacokinetic (PK) analysis was performed, assessing PTA. Results: In the amoxicillin cohort (n=37), 84% of patients and 95% of all plasma amoxicillin concentrations were above or at the threshold throughout the dialysis procedure. In the clindamycin cohort (n=33), all concentrations were above the threshold throughout the dialysis procedure. Further, in all patients, the mean plasma concentration of both amoxicillin and clindamycin across the HD period was well above the threshold. Finally, the PK model predicted a high PTA in the majority of patients. Discussion: In patients on chronic HD, oral administration of amoxicillin/clavulanic acid (500/125 mg) or clindamycin (600 mg) within 30-120 min prior to HD leads to a sufficient prophylactic plasma concentration across the HD period. ",
author = "Solli, {Camilla N.} and Magnus Bock and Kaur, {Kamal P.} and Kristensen, {Jonas H.} and Eva Greibe and Hansen, {Henrik P.} and Lene Boesby and Rikke Borg and Mavish Chaudry and Elke Hoffmann-L{\"u}cke and Claus Moser and Falkentoft, {Alexander C.} and Emil Fosb{\o}l and Lauge {\O}stergaard and Christian Torp-Pedersen and Henning Bundgaard and Kasper Iversen and Bruun, {Niels E.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.",
year = "2023",
doi = "10.1093/jac/dkad002",
language = "English",
volume = "78",
pages = "724--731",
journal = "Journal of Antimicrobial Chemotherapy",
issn = "0305-7453",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - Plasma concentration of orally administered amoxicillin and clindamycin in patients receiving haemodialysis

AU - Solli, Camilla N.

AU - Bock, Magnus

AU - Kaur, Kamal P.

AU - Kristensen, Jonas H.

AU - Greibe, Eva

AU - Hansen, Henrik P.

AU - Boesby, Lene

AU - Borg, Rikke

AU - Chaudry, Mavish

AU - Hoffmann-Lücke, Elke

AU - Moser, Claus

AU - Falkentoft, Alexander C.

AU - Fosbøl, Emil

AU - Østergaard, Lauge

AU - Torp-Pedersen, Christian

AU - Bundgaard, Henning

AU - Iversen, Kasper

AU - Bruun, Niels E.

N1 - Publisher Copyright: © 2023 The Author(s). Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy.

PY - 2023

Y1 - 2023

N2 - Objectives: In the randomized controlled trial PANTHEM, the prophylactic effect of oral amoxicillin or clindamycin is investigated in patients receiving chronic haemodialysis (HD). However, data on plasma concentrations of these antibiotics during HD are sparse. This study aims to determine if the plasma concentration of amoxicillin and clindamycin is sufficient during HD after oral administration of amoxicillin and clindamycin at three different time intervals prior to the HD procedure. Methods: Adult patients receiving chronic HD were investigated twice with an interval of at least 7 days starting with either a tablet of 500/125 mg amoxicillin/clavulanic acid or a tablet of 600 mg clindamycin. Patients were randomized to take the antibiotics either 30, 60 or 120 min prior to the HD procedure. Plasma antibiotic concentrations were measured at start, midway and at the end of HD. A lower threshold was set at 2.0 mg/L for amoxicillin and at 1.0 mg/L for clindamycin. In addition, a population pharmacokinetic (PK) analysis was performed, assessing PTA. Results: In the amoxicillin cohort (n=37), 84% of patients and 95% of all plasma amoxicillin concentrations were above or at the threshold throughout the dialysis procedure. In the clindamycin cohort (n=33), all concentrations were above the threshold throughout the dialysis procedure. Further, in all patients, the mean plasma concentration of both amoxicillin and clindamycin across the HD period was well above the threshold. Finally, the PK model predicted a high PTA in the majority of patients. Discussion: In patients on chronic HD, oral administration of amoxicillin/clavulanic acid (500/125 mg) or clindamycin (600 mg) within 30-120 min prior to HD leads to a sufficient prophylactic plasma concentration across the HD period.

AB - Objectives: In the randomized controlled trial PANTHEM, the prophylactic effect of oral amoxicillin or clindamycin is investigated in patients receiving chronic haemodialysis (HD). However, data on plasma concentrations of these antibiotics during HD are sparse. This study aims to determine if the plasma concentration of amoxicillin and clindamycin is sufficient during HD after oral administration of amoxicillin and clindamycin at three different time intervals prior to the HD procedure. Methods: Adult patients receiving chronic HD were investigated twice with an interval of at least 7 days starting with either a tablet of 500/125 mg amoxicillin/clavulanic acid or a tablet of 600 mg clindamycin. Patients were randomized to take the antibiotics either 30, 60 or 120 min prior to the HD procedure. Plasma antibiotic concentrations were measured at start, midway and at the end of HD. A lower threshold was set at 2.0 mg/L for amoxicillin and at 1.0 mg/L for clindamycin. In addition, a population pharmacokinetic (PK) analysis was performed, assessing PTA. Results: In the amoxicillin cohort (n=37), 84% of patients and 95% of all plasma amoxicillin concentrations were above or at the threshold throughout the dialysis procedure. In the clindamycin cohort (n=33), all concentrations were above the threshold throughout the dialysis procedure. Further, in all patients, the mean plasma concentration of both amoxicillin and clindamycin across the HD period was well above the threshold. Finally, the PK model predicted a high PTA in the majority of patients. Discussion: In patients on chronic HD, oral administration of amoxicillin/clavulanic acid (500/125 mg) or clindamycin (600 mg) within 30-120 min prior to HD leads to a sufficient prophylactic plasma concentration across the HD period.

U2 - 10.1093/jac/dkad002

DO - 10.1093/jac/dkad002

M3 - Journal article

C2 - 36640129

AN - SCOPUS:85164995034

VL - 78

SP - 724

EP - 731

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 3

ER -

ID: 369083629