Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients. / Wen, Hanchun; Wang, Ke; Liu, Yang; Tay, Martin; Lauro, Federico M.; Huang, Hong; Wu, Huayu; Liang, Hongjie; Ding, Yichen; Givskov, Michael; Chen, Yiqiang; Yang, Liang.

In: Journal of clinical microbiology, Vol. 52, No. 9, 09.2014, p. 3200-3208.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wen, H, Wang, K, Liu, Y, Tay, M, Lauro, FM, Huang, H, Wu, H, Liang, H, Ding, Y, Givskov, M, Chen, Y & Yang, L 2014, 'Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients', Journal of clinical microbiology, vol. 52, no. 9, pp. 3200-3208. https://doi.org/10.1128/JCM.00921-14

APA

Wen, H., Wang, K., Liu, Y., Tay, M., Lauro, F. M., Huang, H., Wu, H., Liang, H., Ding, Y., Givskov, M., Chen, Y., & Yang, L. (2014). Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients. Journal of clinical microbiology, 52(9), 3200-3208. https://doi.org/10.1128/JCM.00921-14

Vancouver

Wen H, Wang K, Liu Y, Tay M, Lauro FM, Huang H et al. Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients. Journal of clinical microbiology. 2014 Sep;52(9):3200-3208. https://doi.org/10.1128/JCM.00921-14

Author

Wen, Hanchun ; Wang, Ke ; Liu, Yang ; Tay, Martin ; Lauro, Federico M. ; Huang, Hong ; Wu, Huayu ; Liang, Hongjie ; Ding, Yichen ; Givskov, Michael ; Chen, Yiqiang ; Yang, Liang. / Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients. In: Journal of clinical microbiology. 2014 ; Vol. 52, No. 9. pp. 3200-3208.

Bibtex

@article{a915196549364b08b763118bc26a02b3,
title = "Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients",
abstract = "Acinetobacter baumannii has emerged as one of the leading pathogens causing hospital-acquired infection. The success of A. baumannii as a pathogen has to a large extent been attributed to its capacity to remodel its genome. Several major epidemic clonal complexes of A. baumannii spread across different health care facilities around the world, each of which contains a subset of diversified strains. However, little is known about the population dynamics during colonization of A. baumannii within hosts. Here, whole-genome sequencing was used to analyze population dynamics of A. baumannii strains isolated from a group of patients at different time points as well as from different sites of a particular patient. Seven out of nine of the sampled A. baumannii strains belonged to the international clone II (CC92 clonal complex). While the A. baumannii strains were found to be stable in three patients, there was a change of A. baumannii strains in one patient. Comparative genomic analysis revealed that the accessory genome of these strains contained a large set of virulence-encoding genes and these virulence factors might play a role in determining population dynamics. Microscale genome modification has been revealed by analysis of single nucleotide polymorphisms (SNPs) between A. baumannii strains isolated from the same patient. Parallel evolutionary traits have been observed during genome diversification when A. baumannii colonize in different patients. Our study suggested that both antibiotic usage and host environment might impose selective forces that drive the rapid adaptive evolution in colonizing A. baumannii.",
author = "Hanchun Wen and Ke Wang and Yang Liu and Martin Tay and Lauro, {Federico M.} and Hong Huang and Huayu Wu and Hongjie Liang and Yichen Ding and Michael Givskov and Yiqiang Chen and Liang Yang",
year = "2014",
month = sep,
doi = "10.1128/JCM.00921-14",
language = "English",
volume = "52",
pages = "3200--3208",
journal = "Journal of clinical microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "9",

}

RIS

TY - JOUR

T1 - Population dynamics of an Acinetobacter baumannii clonal complex during colonization of patients

AU - Wen, Hanchun

AU - Wang, Ke

AU - Liu, Yang

AU - Tay, Martin

AU - Lauro, Federico M.

AU - Huang, Hong

AU - Wu, Huayu

AU - Liang, Hongjie

AU - Ding, Yichen

AU - Givskov, Michael

AU - Chen, Yiqiang

AU - Yang, Liang

PY - 2014/9

Y1 - 2014/9

N2 - Acinetobacter baumannii has emerged as one of the leading pathogens causing hospital-acquired infection. The success of A. baumannii as a pathogen has to a large extent been attributed to its capacity to remodel its genome. Several major epidemic clonal complexes of A. baumannii spread across different health care facilities around the world, each of which contains a subset of diversified strains. However, little is known about the population dynamics during colonization of A. baumannii within hosts. Here, whole-genome sequencing was used to analyze population dynamics of A. baumannii strains isolated from a group of patients at different time points as well as from different sites of a particular patient. Seven out of nine of the sampled A. baumannii strains belonged to the international clone II (CC92 clonal complex). While the A. baumannii strains were found to be stable in three patients, there was a change of A. baumannii strains in one patient. Comparative genomic analysis revealed that the accessory genome of these strains contained a large set of virulence-encoding genes and these virulence factors might play a role in determining population dynamics. Microscale genome modification has been revealed by analysis of single nucleotide polymorphisms (SNPs) between A. baumannii strains isolated from the same patient. Parallel evolutionary traits have been observed during genome diversification when A. baumannii colonize in different patients. Our study suggested that both antibiotic usage and host environment might impose selective forces that drive the rapid adaptive evolution in colonizing A. baumannii.

AB - Acinetobacter baumannii has emerged as one of the leading pathogens causing hospital-acquired infection. The success of A. baumannii as a pathogen has to a large extent been attributed to its capacity to remodel its genome. Several major epidemic clonal complexes of A. baumannii spread across different health care facilities around the world, each of which contains a subset of diversified strains. However, little is known about the population dynamics during colonization of A. baumannii within hosts. Here, whole-genome sequencing was used to analyze population dynamics of A. baumannii strains isolated from a group of patients at different time points as well as from different sites of a particular patient. Seven out of nine of the sampled A. baumannii strains belonged to the international clone II (CC92 clonal complex). While the A. baumannii strains were found to be stable in three patients, there was a change of A. baumannii strains in one patient. Comparative genomic analysis revealed that the accessory genome of these strains contained a large set of virulence-encoding genes and these virulence factors might play a role in determining population dynamics. Microscale genome modification has been revealed by analysis of single nucleotide polymorphisms (SNPs) between A. baumannii strains isolated from the same patient. Parallel evolutionary traits have been observed during genome diversification when A. baumannii colonize in different patients. Our study suggested that both antibiotic usage and host environment might impose selective forces that drive the rapid adaptive evolution in colonizing A. baumannii.

U2 - 10.1128/JCM.00921-14

DO - 10.1128/JCM.00921-14

M3 - Journal article

C2 - 24951812

AN - SCOPUS:84906862057

VL - 52

SP - 3200

EP - 3208

JO - Journal of clinical microbiology

JF - Journal of clinical microbiology

SN - 0095-1137

IS - 9

ER -

ID: 340026315