Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

Research output: Contribution to journal › Review › Research › peer-review

Standard

Pseudomonas aeruginosa Biofilm Infections : Community Structure, Antimicrobial Tolerance and Immune Response. / Rybtke, Morten; Hultqvist, Louise Dahl; Givskov, Michael; Tolker-Nielsen, Tim.

In: Journal of Molecular Biology, Vol. 427, No. 23, 2015, p. 3628-3645.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rybtke, M, Hultqvist, LD, Givskov, M & Tolker-Nielsen, T 2015, 'Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response', Journal of Molecular Biology, vol. 427, no. 23, pp. 3628-3645. https://doi.org/10.1016/j.jmb.2015.08.016

APA

Rybtke, M., Hultqvist, L. D., Givskov, M., & Tolker-Nielsen, T. (2015). Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response. Journal of Molecular Biology, 427(23), 3628-3645. https://doi.org/10.1016/j.jmb.2015.08.016

Vancouver

Rybtke M, Hultqvist LD, Givskov M, Tolker-Nielsen T. Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response. Journal of Molecular Biology. 2015;427(23):3628-3645. https://doi.org/10.1016/j.jmb.2015.08.016

Author

Rybtke, Morten ; Hultqvist, Louise Dahl ; Givskov, Michael ; Tolker-Nielsen, Tim. / Pseudomonas aeruginosa Biofilm Infections : Community Structure, Antimicrobial Tolerance and Immune Response. In: Journal of Molecular Biology. 2015 ; Vol. 427, No. 23. pp. 3628-3645.

Bibtex

@article{4c0e3de2dd3141cbbb6a8c1e7890aa2b,
title = "Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response",
abstract = "Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.",
author = "Morten Rybtke and Hultqvist, {Louise Dahl} and Michael Givskov and Tim Tolker-Nielsen",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
doi = "10.1016/j.jmb.2015.08.016",
language = "English",
volume = "427",
pages = "3628--3645",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "23",

}

RIS

TY - JOUR

T1 - Pseudomonas aeruginosa Biofilm Infections

T2 - Community Structure, Antimicrobial Tolerance and Immune Response

AU - Rybtke, Morten

AU - Hultqvist, Louise Dahl

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015

Y1 - 2015

N2 - Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.

AB - Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.

U2 - 10.1016/j.jmb.2015.08.016

DO - 10.1016/j.jmb.2015.08.016

M3 - Review

C2 - 26319792

VL - 427

SP - 3628

EP - 3645

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

SN - 0022-2836

IS - 23

ER -

ID: 152934511