Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria

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Standard

Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria. / Persson, Tobias; Givskov, Michael; Nielsen, John.

In: Current Medicinal Chemistry, Vol. 12, No. 26, 2005, p. 3103-15.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Persson, T, Givskov, M & Nielsen, J 2005, 'Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria', Current Medicinal Chemistry, vol. 12, no. 26, pp. 3103-15.

APA

Persson, T., Givskov, M., & Nielsen, J. (2005). Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria. Current Medicinal Chemistry, 12(26), 3103-15.

Vancouver

Persson T, Givskov M, Nielsen J. Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria. Current Medicinal Chemistry. 2005;12(26):3103-15.

Author

Persson, Tobias ; Givskov, Michael ; Nielsen, John. / Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria. In: Current Medicinal Chemistry. 2005 ; Vol. 12, No. 26. pp. 3103-15.

Bibtex

@article{f1aeb0c0fce911ddb219000ea68e967b,
title = "Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria",
abstract = "Quorum sensing (QS) systems comprise a new therapeutic target potentially substitutive or complementary to traditional antibiotic treatment of chronic diseases. One route to disrupt the previously established interrelationship between pathogenesis and QS is by blocking the dual functioning signal/receptor transcriptional regulator in some clinically relevant Gram-negative bacteria. The present review contains all reported compound types that are currently known to inhibit the QS transcriptional regulator in Gram-negative bacteria. These compounds are sub-divided into two main groups, one comprising structural analogs of the native signaling molecules and the other compounds lacking structural resemblance. Biological activity is rationalized on the basis of structure-activity relationships and structural insight into the target protein.",
author = "Tobias Persson and Michael Givskov and John Nielsen",
note = "Keywords: Anti-Bacterial Agents; Bacterial Proteins; Cell Communication; Gram-Negative Bacteria; Structure-Activity Relationship; Transcription Factors",
year = "2005",
language = "English",
volume = "12",
pages = "3103--15",
journal = "Current Medicinal Chemistry",
issn = "0929-8673",
publisher = "Bentham Science Publishers",
number = "26",

}

RIS

TY - JOUR

T1 - Quorum sensing inhibition: targeting chemical communication in gram-negative bacteria

AU - Persson, Tobias

AU - Givskov, Michael

AU - Nielsen, John

N1 - Keywords: Anti-Bacterial Agents; Bacterial Proteins; Cell Communication; Gram-Negative Bacteria; Structure-Activity Relationship; Transcription Factors

PY - 2005

Y1 - 2005

N2 - Quorum sensing (QS) systems comprise a new therapeutic target potentially substitutive or complementary to traditional antibiotic treatment of chronic diseases. One route to disrupt the previously established interrelationship between pathogenesis and QS is by blocking the dual functioning signal/receptor transcriptional regulator in some clinically relevant Gram-negative bacteria. The present review contains all reported compound types that are currently known to inhibit the QS transcriptional regulator in Gram-negative bacteria. These compounds are sub-divided into two main groups, one comprising structural analogs of the native signaling molecules and the other compounds lacking structural resemblance. Biological activity is rationalized on the basis of structure-activity relationships and structural insight into the target protein.

AB - Quorum sensing (QS) systems comprise a new therapeutic target potentially substitutive or complementary to traditional antibiotic treatment of chronic diseases. One route to disrupt the previously established interrelationship between pathogenesis and QS is by blocking the dual functioning signal/receptor transcriptional regulator in some clinically relevant Gram-negative bacteria. The present review contains all reported compound types that are currently known to inhibit the QS transcriptional regulator in Gram-negative bacteria. These compounds are sub-divided into two main groups, one comprising structural analogs of the native signaling molecules and the other compounds lacking structural resemblance. Biological activity is rationalized on the basis of structure-activity relationships and structural insight into the target protein.

M3 - Journal article

C2 - 16375704

VL - 12

SP - 3103

EP - 3115

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

SN - 0929-8673

IS - 26

ER -

ID: 10614091