rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine
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rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine. / Krogfelt, K A; Hjulgaard, M; Sørensen, K; Cohen, Paul; Givskov, M.
In: Infection and Immunity, Vol. 68, No. 5, 2000, p. 2518-24.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine
AU - Krogfelt, K A
AU - Hjulgaard, M
AU - Sørensen, K
AU - Cohen, Paul
AU - Givskov, M
PY - 2000
Y1 - 2000
N2 - The ability of Escherichia coli to survive stress during growth in different environments is, in large part, dependent on rpoS and the genes that comprise the rpoS regulon. E. coli BJ4 and an isogenic BJ4 rpoS mutant were used to examine the influence of the rpoS gene on E. coli colonization of the streptomycin-treated mouse large intestine. Colonization experiments in which the wild-type E. coli BJ4 and its rpoS mutant were fed individually as well as simultaneously to mice suggested that E. coli BJ4 does not face prolonged periods of nutrient starvation in the mouse large intestine and that the rpoS regulon is not expressed during long-term colonization after adaptation of the bacteria to the gut environment.
AB - The ability of Escherichia coli to survive stress during growth in different environments is, in large part, dependent on rpoS and the genes that comprise the rpoS regulon. E. coli BJ4 and an isogenic BJ4 rpoS mutant were used to examine the influence of the rpoS gene on E. coli colonization of the streptomycin-treated mouse large intestine. Colonization experiments in which the wild-type E. coli BJ4 and its rpoS mutant were fed individually as well as simultaneously to mice suggested that E. coli BJ4 does not face prolonged periods of nutrient starvation in the mouse large intestine and that the rpoS regulon is not expressed during long-term colonization after adaptation of the bacteria to the gut environment.
M3 - Journal article
C2 - 10768939
VL - 68
SP - 2518
EP - 2524
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 5
ER -
ID: 44305745