Sinus surgery postpones chronic gram-negative lung infection: Cohort study of 106 patients with cystic fibrosis
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Sinus surgery postpones chronic gram-negative lung infection : Cohort study of 106 patients with cystic fibrosis. / Alanin, M C; Aanaes, K; Høiby, N; Pressler, T; Skov, M; Nielsen, K G; Taylor-Robinson, D; Waldmann, E; Johansen, H Krogh; von Buchwald, C.
In: Rhinology, Vol. 54, No. 3, 2016, p. 206-213.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sinus surgery postpones chronic gram-negative lung infection
T2 - Cohort study of 106 patients with cystic fibrosis
AU - Alanin, M C
AU - Aanaes, K
AU - Høiby, N
AU - Pressler, T
AU - Skov, M
AU - Nielsen, K G
AU - Taylor-Robinson, D
AU - Waldmann, E
AU - Johansen, H Krogh
AU - von Buchwald, C
PY - 2016
Y1 - 2016
N2 - Background: In patients with cystic fibrosis (CF) the sinuses are a bacterial reservoir for Gram-negative bacteria (GNB). From the sinuses the GNB can repeatedly migrate to the lungs. In a one-year follow-up study, endoscopic sinus surgery (ESS) with adjuvant therapy reduced the frequency of pulmonary samples positive for GNB. We investigated whether the effect is sustained. Methodology: We report the effect of ESS and adjuvant therapy three years postoperatively in a CF cohort participating in this prospective clinical follow-up study. The primary endpoint was the lung infection status defined by Leeds criteria. Results: One hundred and six CF patients underwent ESS; 27 had improved lung infection status after three years. The prevalence of patients free of lung colonization with GNB significantly increased from 16/106 patients (15%) preoperatively to 35/106 patients (33%) after three years. The total cohort had decreasing lung function during follow-up; however, in 27 patients with improved lung infection status lung function was stable. Revision surgery was performed in 31 patients (28%). Conclusion: ESS with adjuvant therapy significantly improves the lung infection status for at least three years in our cohort of patients with CF and may postpone chronic lung infection with GNB and thus stabilize lung function.
AB - Background: In patients with cystic fibrosis (CF) the sinuses are a bacterial reservoir for Gram-negative bacteria (GNB). From the sinuses the GNB can repeatedly migrate to the lungs. In a one-year follow-up study, endoscopic sinus surgery (ESS) with adjuvant therapy reduced the frequency of pulmonary samples positive for GNB. We investigated whether the effect is sustained. Methodology: We report the effect of ESS and adjuvant therapy three years postoperatively in a CF cohort participating in this prospective clinical follow-up study. The primary endpoint was the lung infection status defined by Leeds criteria. Results: One hundred and six CF patients underwent ESS; 27 had improved lung infection status after three years. The prevalence of patients free of lung colonization with GNB significantly increased from 16/106 patients (15%) preoperatively to 35/106 patients (33%) after three years. The total cohort had decreasing lung function during follow-up; however, in 27 patients with improved lung infection status lung function was stable. Revision surgery was performed in 31 patients (28%). Conclusion: ESS with adjuvant therapy significantly improves the lung infection status for at least three years in our cohort of patients with CF and may postpone chronic lung infection with GNB and thus stabilize lung function.
KW - ESS
KW - Lower airway cultures
KW - Pseudomonas aeruginosa
KW - Pulmonary function
KW - Quality of life
UR - http://www.rhinologyjournal.com/Abstract.php?id=1455
U2 - 10.4193/Rhino15.347
DO - 10.4193/Rhino15.347
M3 - Journal article
AN - SCOPUS:84986888444
VL - 54
SP - 206
EP - 213
JO - Rhinology. Supplement
JF - Rhinology. Supplement
SN - 1013-0047
IS - 3
ER -
ID: 179216886