Suicidal genetic elements and their use in biological containment of bacteria

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Suicidal genetic elements and their use in biological containment of bacteria. / Molin, Søren; Boe, Lars; Jensen, L B; Kristensen, C S; Givskov, M; Ramos, J L; Bej, A K.

In: Annual Review of Microbiology, Vol. 47, 1993, p. 139-66.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Molin, S, Boe, L, Jensen, LB, Kristensen, CS, Givskov, M, Ramos, JL & Bej, AK 1993, 'Suicidal genetic elements and their use in biological containment of bacteria', Annual Review of Microbiology, vol. 47, pp. 139-66. https://doi.org/10.1146/annurev.mi.47.100193.001035

APA

Molin, S., Boe, L., Jensen, L. B., Kristensen, C. S., Givskov, M., Ramos, J. L., & Bej, A. K. (1993). Suicidal genetic elements and their use in biological containment of bacteria. Annual Review of Microbiology, 47, 139-66. https://doi.org/10.1146/annurev.mi.47.100193.001035

Vancouver

Molin S, Boe L, Jensen LB, Kristensen CS, Givskov M, Ramos JL et al. Suicidal genetic elements and their use in biological containment of bacteria. Annual Review of Microbiology. 1993;47:139-66. https://doi.org/10.1146/annurev.mi.47.100193.001035

Author

Molin, Søren ; Boe, Lars ; Jensen, L B ; Kristensen, C S ; Givskov, M ; Ramos, J L ; Bej, A K. / Suicidal genetic elements and their use in biological containment of bacteria. In: Annual Review of Microbiology. 1993 ; Vol. 47. pp. 139-66.

Bibtex

@article{187a5aa54a164925b1dc9f958301c593,
title = "Suicidal genetic elements and their use in biological containment of bacteria",
abstract = "The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.",
author = "S{\o}ren Molin and Lars Boe and Jensen, {L B} and Kristensen, {C S} and M Givskov and Ramos, {J L} and Bej, {A K}",
year = "1993",
doi = "10.1146/annurev.mi.47.100193.001035",
language = "English",
volume = "47",
pages = "139--66",
journal = "Annual Review of Microbiology",
issn = "0066-4227",
publisher = "Annual Reviews, inc.",

}

RIS

TY - JOUR

T1 - Suicidal genetic elements and their use in biological containment of bacteria

AU - Molin, Søren

AU - Boe, Lars

AU - Jensen, L B

AU - Kristensen, C S

AU - Givskov, M

AU - Ramos, J L

AU - Bej, A K

PY - 1993

Y1 - 1993

N2 - The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.

AB - The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.

U2 - 10.1146/annurev.mi.47.100193.001035

DO - 10.1146/annurev.mi.47.100193.001035

M3 - Journal article

C2 - 8257096

VL - 47

SP - 139

EP - 166

JO - Annual Review of Microbiology

JF - Annual Review of Microbiology

SN - 0066-4227

ER -

ID: 44293715