Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics
Research output: Contribution to journal › Journal article › Research › peer-review
A practical and scalable 4-step route is presented for the synthesis of 4-bromo-3-fluoro-6-methoxyoquinoline and 3-fluoro-4-iodo-6-methoxyoquinoline from readily available 2,4-dichloro-3-fluoroquinoline with an overall yield of 81-85%. Halogenated quinoline building blocks have found much use in antimicrobial drug discovery, and the method reported here would be useful for the synthesis of these compounds.
Original language | English |
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Journal | Synthesis (Germany) |
Volume | 46 |
Issue number | 23 |
Pages (from-to) | 3263-3267 |
Number of pages | 5 |
ISSN | 0039-7881 |
DOIs | |
Publication status | Published - 28 Aug 2014 |
Bibliographical note
Publisher Copyright:
© Georg Thieme Verlag Stuttgart · New York.
- antibiotic, fluorine, heterocycle, quinolone, regioselectivity
Research areas
ID: 340026011