Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers
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Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers. / Olsen, J A; Severinsen, Rune Eg; Rasmussen, T B; Hentzer, Morten; Givskov, M; Nielsen, J.
In: Bioorganic & Medicinal Chemistry Letters, Vol. 12, No. 3, 2002, p. 325-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers
AU - Olsen, J A
AU - Severinsen, Rune Eg
AU - Rasmussen, T B
AU - Hentzer, Morten
AU - Givskov, M
AU - Nielsen, J
PY - 2002
Y1 - 2002
N2 - The quorum sensing mechanism in Gram-negative bacteria uses small intercellular signal molecules, N-acyl-homoserine lactones (AHLs), to control transcription of specific genes in relation to population density. In this communication, we describe the parallel synthesis of new AHL analogues, in which substituents have been introduced into the 3- and 4-positions of the lactone ring. These analogues have been screened for their ability to activate and inhibit a Vibrio fischeri LuxI/LuxR-derived quorum sensing reporter system.
AB - The quorum sensing mechanism in Gram-negative bacteria uses small intercellular signal molecules, N-acyl-homoserine lactones (AHLs), to control transcription of specific genes in relation to population density. In this communication, we describe the parallel synthesis of new AHL analogues, in which substituents have been introduced into the 3- and 4-positions of the lactone ring. These analogues have been screened for their ability to activate and inhibit a Vibrio fischeri LuxI/LuxR-derived quorum sensing reporter system.
M3 - Journal article
C2 - 11814788
VL - 12
SP - 325
EP - 328
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -
ID: 44310192