Targeting quorum sensing for treatment of chronic bacterial biofilm infections

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Targeting quorum sensing for treatment of chronic bacterial biofilm infections. / Hentzer, Morten; Givskov, Michael; Parsek, Matthew R.

In: Laboratory Medicine, Vol. 33, No. 4, 2002, p. 295-306.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hentzer, M, Givskov, M & Parsek, MR 2002, 'Targeting quorum sensing for treatment of chronic bacterial biofilm infections', Laboratory Medicine, vol. 33, no. 4, pp. 295-306. https://doi.org/10.1309/EYEV-WT6T-GKHE-C8LM

APA

Hentzer, M., Givskov, M., & Parsek, M. R. (2002). Targeting quorum sensing for treatment of chronic bacterial biofilm infections. Laboratory Medicine, 33(4), 295-306. https://doi.org/10.1309/EYEV-WT6T-GKHE-C8LM

Vancouver

Hentzer M, Givskov M, Parsek MR. Targeting quorum sensing for treatment of chronic bacterial biofilm infections. Laboratory Medicine. 2002;33(4):295-306. https://doi.org/10.1309/EYEV-WT6T-GKHE-C8LM

Author

Hentzer, Morten ; Givskov, Michael ; Parsek, Matthew R. / Targeting quorum sensing for treatment of chronic bacterial biofilm infections. In: Laboratory Medicine. 2002 ; Vol. 33, No. 4. pp. 295-306.

Bibtex

@article{9a81071ee8ba47ff9edb949624cdeba0,
title = "Targeting quorum sensing for treatment of chronic bacterial biofilm infections",
abstract = "Cell-to-cell communication presents an enticing target for therapeutic strategies directed towards Pseudomonas aeruginosa infections. Quorum sensing not only regulates a battery of secreted virulence factors, but is required for the establishment of surface-attached, antimicrobial resistant communities called biofilms that have been implicated in chronic infection. A range of potential targets include, signal synthesis, reception, and stability. The widespread prevalence of cell-to-cell signaling mechanisms in bacteria as well as biofilm-mediated infections suggests that developed therapeutic strategies may have wide ranging applications.",
author = "Morten Hentzer and Michael Givskov and Parsek, {Matthew R.}",
year = "2002",
doi = "10.1309/EYEV-WT6T-GKHE-C8LM",
language = "English",
volume = "33",
pages = "295--306",
journal = "Laboratory Medicine",
issn = "0007-5027",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Targeting quorum sensing for treatment of chronic bacterial biofilm infections

AU - Hentzer, Morten

AU - Givskov, Michael

AU - Parsek, Matthew R.

PY - 2002

Y1 - 2002

N2 - Cell-to-cell communication presents an enticing target for therapeutic strategies directed towards Pseudomonas aeruginosa infections. Quorum sensing not only regulates a battery of secreted virulence factors, but is required for the establishment of surface-attached, antimicrobial resistant communities called biofilms that have been implicated in chronic infection. A range of potential targets include, signal synthesis, reception, and stability. The widespread prevalence of cell-to-cell signaling mechanisms in bacteria as well as biofilm-mediated infections suggests that developed therapeutic strategies may have wide ranging applications.

AB - Cell-to-cell communication presents an enticing target for therapeutic strategies directed towards Pseudomonas aeruginosa infections. Quorum sensing not only regulates a battery of secreted virulence factors, but is required for the establishment of surface-attached, antimicrobial resistant communities called biofilms that have been implicated in chronic infection. A range of potential targets include, signal synthesis, reception, and stability. The widespread prevalence of cell-to-cell signaling mechanisms in bacteria as well as biofilm-mediated infections suggests that developed therapeutic strategies may have wide ranging applications.

UR - http://www.scopus.com/inward/record.url?scp=0036193971&partnerID=8YFLogxK

U2 - 10.1309/EYEV-WT6T-GKHE-C8LM

DO - 10.1309/EYEV-WT6T-GKHE-C8LM

M3 - Review

AN - SCOPUS:0036193971

VL - 33

SP - 295

EP - 306

JO - Laboratory Medicine

JF - Laboratory Medicine

SN - 0007-5027

IS - 4

ER -

ID: 340024891