The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms
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The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms. / Zhang, Lianbo; Chiang, Wen-Chi; Gao, Qingguo; Givskov, Michael; Tolker-Nielsen, Tim; Yang, Liang; Zhang, Guang.
In: Microbiology, Vol. 158, No. 12, 12.2012, p. 3014-3019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms
AU - Zhang, Lianbo
AU - Chiang, Wen-Chi
AU - Gao, Qingguo
AU - Givskov, Michael
AU - Tolker-Nielsen, Tim
AU - Yang, Liang
AU - Zhang, Guang
PY - 2012/12
Y1 - 2012/12
N2 - Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells differentiate into subpopulations which display tolerance towards antimicrobial agents. However, the signal transduction pathways regulating subpopulation differentiation in biofilms are largely unelucidated. In the present study, we show that the catabolite repression control protein Crc regulates the metabolic state of Pseudomonas aeruginosa cells in biofilms, and plays an important role in the development of antimicrobial-tolerant subpopulations in P. aeruginosa biofilms.
AB - Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells differentiate into subpopulations which display tolerance towards antimicrobial agents. However, the signal transduction pathways regulating subpopulation differentiation in biofilms are largely unelucidated. In the present study, we show that the catabolite repression control protein Crc regulates the metabolic state of Pseudomonas aeruginosa cells in biofilms, and plays an important role in the development of antimicrobial-tolerant subpopulations in P. aeruginosa biofilms.
U2 - 10.1099/mic.0.061192-0
DO - 10.1099/mic.0.061192-0
M3 - Journal article
C2 - 23023972
VL - 158
SP - 3014
EP - 3019
JO - Microbiology
JF - Microbiology
SN - 1350-0872
IS - 12
ER -
ID: 43251669