The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis
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The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis. / Ravnholt, Cecilie; Kolpen, Mette; Skov, Marianne; Moser, Claus; Katzenstein, Terese L; Pressler, Tania; Høiby, Niels; Qvist, Tavs.
In: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 126, No. 12, 2018, p. 885-891.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The importance of early diagnosis of Mycobacterium abscessus complex in patients with cystic fibrosis
AU - Ravnholt, Cecilie
AU - Kolpen, Mette
AU - Skov, Marianne
AU - Moser, Claus
AU - Katzenstein, Terese L
AU - Pressler, Tania
AU - Høiby, Niels
AU - Qvist, Tavs
N1 - © 2018 APMIS. Published by John Wiley & Sons Ltd.
PY - 2018
Y1 - 2018
N2 - Mycobacterium abscessus complex can cause severe lung infections and has proven to be a serious threat to patients with cystic fibrosis and a challenge for clinicians due to difficulties in timely diagnosis and complex multidrug treatment regimes. Mycobacterial culture is the gold standard for diagnosis, but in most cystic fibrosis centers it is performed less frequently than culture for other pathogens. Consensus today recommends just one annual mycobacterial culture for asymptomatic patients with cystic fibrosis, a strategy likely to lead to diagnostic delays. Postponement of diagnosis might be the deciding factor in whether an early colonization turns into chronic infection. This review highlights the latest developments in knowledge about the pathogenicity and clinical consequences of M. abscessus complex pulmonary disease, addressing the central theme of why pulmonary infection requires early identification and aggressive antibiotic treatment. The window of opportunity, before M. abscessus complex transforms from a mucosal colonizer to a chronic biofilm infection, is where microbial eradication is most likely to be successful, making early diagnosis essential for improved outcomes.
AB - Mycobacterium abscessus complex can cause severe lung infections and has proven to be a serious threat to patients with cystic fibrosis and a challenge for clinicians due to difficulties in timely diagnosis and complex multidrug treatment regimes. Mycobacterial culture is the gold standard for diagnosis, but in most cystic fibrosis centers it is performed less frequently than culture for other pathogens. Consensus today recommends just one annual mycobacterial culture for asymptomatic patients with cystic fibrosis, a strategy likely to lead to diagnostic delays. Postponement of diagnosis might be the deciding factor in whether an early colonization turns into chronic infection. This review highlights the latest developments in knowledge about the pathogenicity and clinical consequences of M. abscessus complex pulmonary disease, addressing the central theme of why pulmonary infection requires early identification and aggressive antibiotic treatment. The window of opportunity, before M. abscessus complex transforms from a mucosal colonizer to a chronic biofilm infection, is where microbial eradication is most likely to be successful, making early diagnosis essential for improved outcomes.
KW - Anti-Bacterial Agents/therapeutic use
KW - Carrier State/diagnosis
KW - Cystic Fibrosis/complications
KW - Early Diagnosis
KW - Humans
KW - Mass Screening/methods
KW - Mycobacterium Infections, Nontuberculous/diagnosis
KW - Mycobacterium abscessus/isolation & purification
KW - Pneumonia, Bacterial/diagnosis
U2 - 10.1111/apm.12903
DO - 10.1111/apm.12903
M3 - Journal article
C2 - 30456869
VL - 126
SP - 885
EP - 891
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 12
ER -
ID: 219526595