The non-attached biofilm aggregate
Research output: Contribution to journal › Review › Research › peer-review
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The non-attached biofilm aggregate. / Kragh, Kasper N.; Tolker-Nielsen, Tim; Lichtenberg, Mads.
In: Communications Biology , Vol. 6, 898, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The non-attached biofilm aggregate
AU - Kragh, Kasper N.
AU - Tolker-Nielsen, Tim
AU - Lichtenberg, Mads
N1 - Publisher Copyright: © 2023, Springer Nature Limited.
PY - 2023
Y1 - 2023
N2 - Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in chronic infections. Understanding their nature sparked fervent discussions in biofilm conferences and scientific literature. This review consolidates current insights on non-attached aggregates, offering examples of their occurrence in nature and diseases. We discuss their formation and dispersion mechanisms, resilience to antibiotics and immune-responses, drawing parallels to surface-attached biofilms. Moreover, we outline available in vitro models for studying non-attached aggregates.
AB - Biofilms have conventionally been perceived as dense bacterial masses on surfaces, following the five-step model of development. Initial biofilm research focused on surface-attached formations, but detached aggregates have received increasing attention in the past decade due to their pivotal role in chronic infections. Understanding their nature sparked fervent discussions in biofilm conferences and scientific literature. This review consolidates current insights on non-attached aggregates, offering examples of their occurrence in nature and diseases. We discuss their formation and dispersion mechanisms, resilience to antibiotics and immune-responses, drawing parallels to surface-attached biofilms. Moreover, we outline available in vitro models for studying non-attached aggregates.
U2 - 10.1038/s42003-023-05281-4
DO - 10.1038/s42003-023-05281-4
M3 - Review
C2 - 37658117
AN - SCOPUS:85169528193
VL - 6
JO - Communications Biology
JF - Communications Biology
SN - 2399-3642
M1 - 898
ER -
ID: 368637193