Michael Givskov

Michael Givskov

Professor

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    ORCID: 0000-0001-5004-8609

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    1. rpoS gene function is a disadvantage for Escherichia coli BJ4 during competitive colonization of the mouse large intestine

      Krogfelt, K. A., Hjulgaard, M., Sørensen, K., Cohen, P. & Givskov, Michael, 2000, In: Infection and Immunity. 68, 5, p. 2518-24 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication

      Andersen, J. B., Heydorn, A., Hentzer, M., Eberl, L., Geisenberger, O., Christensen, B. B., Molin, S. & Givskov, Michael, 2001, In: Applied and Environmental Microbiology. 67, 2, p. 575-85 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Why chronic wounds will not heal: a novel hypothesis

      Bjarnsholt, Thomas, Kirketerp-Møller, K., Jensen, Peter Østrup, Madsen, K. G., Phipps, R. K., Krogfelt, K., Høiby, Niels & Givskov, Michael, 2008, In: Wound Repair and Regeneration. 16, 1, p. 2-10 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Well-known quorum sensing inhibitors do not affect bacterial quorum sensing-regulated bean sprout spoilage

      Rasch, M., Rasmussen, T. B., Andersen, J. B., Persson, T., Nielsen, J., Givskov, Michael & Gram, L., 2007, In: Journal of Applied Microbiology. 102, 3, p. 826-37 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Visualizing biofilm by targeting eDNA with long wavelength probe CDr15

      Kwon, H. Y., Kim, J. Y., Liu, X., Lee, J. Y., Yam, J. K. H., Hultqvist, Louise Dahl, Xu, W., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Heo, W., Kim, J. J., Kang, N. Y., Joo, T., Yang, L., Park, S. J., Givskov, Michael & Chang, Y. T., 2019, In: Biomaterials Science. 7, 9, p. 3594-3598 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Visualization of N-acylhomoserine lactone-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere

      Steidle, A., Sigl, K., Schuhegger, R., Ihring, A., Schmid, M., Gantner, S., Stoffels, M., Riedel, K., Givskov, Michael, Hartmann, A., Langebartels, C. & Eberl, L., 2001, In: Applied and Environmental Microbiology. 67, 12, p. 5761-70 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination

      Koh, A. Y., Mikkelsen, P. J., Smith, R. S., Coggshall, K. T., Kamei, A., Givskov, Michael, Lory, S. & Pier, G. B., 1 Dec 2010, In: P L o S One. 5, 12, p. e15131

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1

      Givskov, Michael, Ostling, J., Eberl, L., Lindum, P. W., Christensen, A. B., Christiansen, G., Molin, S. & Kjelleberg, S., 1998, In: Journal of Bacteriology. 180, 3, p. 742-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis

      Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2011, In: Journal of Clinical Microbiology. 49, 12, p. 4352-5 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa

      Hansen, M. R., Jakobsen, Tim Holm, Bang, C. G., Cohrt, A. E., Hansen, C. L., Clausen, J. R. W., Le Quement, S. T., Tolker-Nielsen, Tim, Givskov, Michael & Nielsen, T., 2015, In: Bioorganic & Medicinal Chemistry. 23, 7, p. 1638-1650 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Transposon Mutagenesis in Streptococcus Species

      Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, 2019, Microbial Transposon Mutagenesis: Protocols and Applications. Humana Press, p. 39-49 11 p. (Methods in Molecular Biology, Vol. 2016).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    12. Published

      Transcriptome analysis of Pseudomonas aeruginosa biofilm development: Anaerobic respiration and iron limitation

      Hentzer, M., Eberl, L. & Givskov, Michael, 2005, In: Biofilms. 2, 1, p. 37-61 25 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Transcriptional Activity of Predominant Streptococcus Species at Multiple Oral Sites Associate With Periodontal Status

      Midjord-Belstrøm, Daniel, Constancias, F., Markvart, Merete, Sikora, Martin, Sørensen, Christiane Elisabeth & Givskov, Michael, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 13 p., 752664.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Thermal injury induces impaired function in polymorphonuclear neutrophil granulocytes and reduced control of burn wound infection

      Calum, Henrik Pierre, Moser, Claus Ernst, Jensen, Peter Østrup, Christoffersen, L., Damlund, D. S. M., Alhede, M., Bjarnsholt, Thomas, Hougen, H. P., Givskov, Michael, Jacobsen, G. K. & Høiby, Niels, 2008, In: Clinical and Experimental Immunology. 156, 1, p. 102-110 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

      Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, Jul 2011, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 236-244 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The metabolically active subpopulation in Pseudomonas aeruginosa biofilms survives exposure to membrane-targeting antimicrobials via distinct molecular mechanisms

      Chiang, W., Pamp, S. J., Nilsson, Carl Martin Peter, Givskov, Michael & Tolker-Nielsen, Tim, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 245-256 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. The interaction of thin-film flow, bacterial swarming and cell differentiation in colonies of Serratia liquefaciens

      Bees, M. A., Andresén, P., Mosekilde, E. & Givskov, Michael, 2000, In: Journal of Mathematical Biology. 40, 1, p. 27-63 37 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      The implication of Pseudomonas aeruginosa biofilms in infections

      Rybtke, Morten Levin, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: Inflammation & Allergy - Drug Targets. 10, 2, p. 141-57 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional

      Shrout, J. D., Chopp, D. L., Just, C. L., Hentzer, M., Givskov, Michael & Parsek, M. R., 2006, In: Molecular Microbiology. 62, 5, p. 1264-77 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      The immune system vs. Pseudomonas aeruginosa biofilms

      Jensen, Peter Østrup, Givskov, Michael, Bjarnsholt, Thomas & Moser, C., 2010, In: FEMS Immunology and Medical Microbiology. 59, 3, p. 292-305 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. The identification of a tetracycline resistance gene tet(M), on a Tn916-like transposon, in the Bacillus cereus group

      Agersø, Y., Jensen, L. B., Givskov, Michael & Roberts, M. C., 2002, In: FEMS Microbiology Letters. 214, 2, p. 251-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The exopolysaccharide gene cluster Bcam1330-Bcam1341 is involved in Burkholderia cenocepacia biofilm formation, and its expression is regulated by c-di-GMP and Bcam1349

      Fazli, M., McCarthy, Y., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, Feb 2013, In: MicrobiologyOpen. 2, 1, p. 105-122 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture

      Eilers, K., Hoong Yam, J. K., Liu, X., Goh, Y. F., To, K. N., Paracuellos, P., Morton, R., Brizuela, J., Hui Yong, A. M., Givskov, Michael, Freibert, S. A., Bange, G., Rice, S. A., Steinchen, W. & Filloux, A., 2024, In: Journal of Biological Chemistry. 300, 2, 105659.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms

      Nilsson, Carl Martin Peter, Rybtke, Morten Levin, Givskov, Michael, Høiby, Niels, Twetman, Svante & Tolker-Nielsen, Tim, Sep 2016, In: International Journal of Antimicrobial Agents. 48, 3, p. 298–304

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. The divergent promoters mediating transcription of the par locus of plasmid RP4 are subject to autoregulation

      Eberl, L., Givskov, Michael & Schwab, H., 1992, In: Molecular Microbiology. 6, 14, p. 1969-79 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The contribution of cell-cell signaling and motility to bacterial biofilm formation

      Shrout, J. D., Tolker-Nielsen, Tim, Givskov, Michael & Parsek, M. R., May 2011, In: M R S Bulletin. 36, 5, p. 367-373 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      The clinical impact of bacterial biofilms

      Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. The cep quorum-sensing system of Burkholderia cepacia H111 controls biofilm formation and swarming motility

      Huber, B., Riedel, K., Hentzer, M., Heydorn, A., Gotschlich, A., Givskov, Michael, Molin, S. & Eberl, L., 2001, In: Microbiology. 147, Pt 9, p. 2517-28 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms

      Zhang, L., Chiang, W., Gao, Q., Givskov, Michael, Tolker-Nielsen, Tim, Yang, L. & Zhang, G., Dec 2012, In: Microbiology. 158, 12, p. 3014-3019 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      The bacteriology of chronic venous leg ulcer examined by culture-independent molecular methods

      Thomsen, T. R., Aasholm, M. S., Rudkjøbing, V. B., Saunders, A. M., Bjarnsholt, Thomas, Givskov, Michael, Kirketerp-Møller, K. & Nielsen, P. H., 2010, In: Wound Repair and Regeneration. 18, 1, p. 38-49 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      The bactericidal activity of β-lactam antibiotics is increased by metabolizable sugar species

      Thorsing, M., Bentin, Thomas, Givskov, Michael, Tolker-Nielsen, Tim & Goltermann, Lise, Oct 2015, In: Microbiology. 161, 10, p. 1999-2007 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

      Groizeleau, J., Rybtke, Morten Levin, Andersen, Jens Bo, Berthelsen, J., Liu, Y., Yang, L., Nielsen, Thomas Eiland, Kaever, V., Givskov, Michael & Tolker-Nielsen, Tim, 1 Oct 2016, In: Microbiology. 162, 10, p. 1797-1807 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells

      Kristiansen, S., Bjarnsholt, Thomas, Adeltoft, D., Ifversen, P. & Givskov, Michael, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 116, 5, p. 361-371 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier

      Tran, C. S., Rangel, S. M., Almblad, H., Kierbel, A., Givskov, Michael, Tolker-Nielsen, Tim, Hauser, A. R. & Engel, J. N., Nov 2014, In: P L o S Pathogens. 10, 11, p. 1-11 12 p., e1004479.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      The N-acyl-homoserine lactones from Pseudomonas aeruginosa can be monitored by green flourescent protein in vivo

      Wu, H., Song, Z. J., Lindum, P. W., Moser, C., Givskov, Michael & Høiby, Niels, 1999, In: Netherlands Journal of Medicine. 54, p. 42-42

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors

      Koch, B., Liljefors, T., Persson, T., Nielsen, J., Kjelleberg, S. & Givskov, Michael, 2005, In: Microbiology. 151, Pt 11, p. 3589-602 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      The LapG protein plays a role in Pseudomonas aeruginosa biofilm formation by controlling the presence of the CdrA adhesin on the cell surface

      Rybtke, Morten Levin, Berthelsen, J., Yang, L., Høiby, Niels, Givskov, Michael & Tolker-Nielsen, Tim, Dec 2015, In: MicrobiologyOpen. 4, 6, p. 917-930 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

      Almblad, H., Harrison, J. J., Rybtke, Morten Levin, Groizeleau, J., Givskov, Michael, Parsek, M. R. & Tolker-Nielsen, Tim, Jul 2015, In: Journal of Bacteriology. 197, 13, p. 2190-200 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data

      Lauro, F. M., Senstius, S. J., Cullen, J., Neches, R., Jensen, R. M., Brown, M. V., Darling, A. E., Givskov, Michael, McDougald, D., Hoeke, R., Ostrowski, M., Philip, G. K., Paulsen, I. T. & Grzymski, J. J., 2014, In: PLOS Biology. 12, 9

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

      Fazli, M., O'Connell, A., Nilsson, M., Niehaus, K., Dow, J. M., Givskov, Michael, Ryan, R. P. & Tolker-Nielsen, Tim, 2011, In: Molecular Microbiology. 82, 2, p. 327-41

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells

      Gall Mas, Laura, Fabbri, A., Namini, Martin Rich Javadi, Givskov, Michael, Fiorentini, C. & Krejsgaard, T., 2018, In: International Journal of Molecular Sciences . 19, 5, 11 p., 1408.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      The Acquisition of Resistance to Carbapenem and Macrolide-mediated Quorum Sensing Inhibition by Pseudomonas aeruginosa via a Novel Integrative and Conjugative Element ICETn43716385

      Ding, Y., Teo, J., Drautz-Moses, D. I., Schuster, S. C., Givskov, Michael & Yang, L., 2017, bioRxiv, 95 p.

      Research output: Working paper › Preprint › Research

    43. Published

      Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

      Jakobsen, Tim Holm, Bjarnsholt, Thomas, Jensen, Peter Østrup, Givskov, Michael & Høiby, Niels, Jul 2013, In: Future Microbiology. 8, 7, p. 901-21 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Targeting quorum sensing for treatment of chronic bacterial biofilm infections

      Hentzer, M., Givskov, Michael & Parsek, M. R., 2002, In: Laboratory Medicine. 33, 4, p. 295-306 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    45. Published

      Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice

      Wu, H., Song, Z., Hentzer, M., Andersen, Jens Bo, Molin, S., Givskov, Michael & Høiby, Niels, 2004, In: Journal of Antimicrobial Chemotherapy. 53, 6, p. 1054-61 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers

      Olsen, J. A., Severinsen, R. E., Rasmussen, T. B., Hentzer, M., Givskov, Michael & Nielsen, J., 2002, In: Bioorganic & Medicinal Chemistry Letters. 12, 3, p. 325-8 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers

      Olsen, J. A., Severinsen, R., Rasmussen, T. B., Hentzer, M., Givskov, Michael, Nielsen, J. & Nielsen, J., 11 Feb 2002, In: Bioorganic and Medicinal Chemistry Letters. 12, 3, p. 325-328 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity

      Hjelmgaard, T., Persson, T., Rasmussen, T. B., Givskov, Michael & Nielsen, J., 2003, In: Bioorganic & Medicinal Chemistry. 11, 15, p. 3261-71 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Synthesis of Substituted γ- and δ-Lactams through Mannich-Type Reactions of Solid-Supported N-Acyliminium Ions

      Komnatnyy, V. V., Taveras, K. M., Nandurkar, N. S., Le Quement, S. T., Givskov, Michael & Nielsen, T. E., Jun 2015, In: European Journal of Organic Chemistry. 2015, 16, p. 3524-3530 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Synthesis of 4-halogenated 3-fluoro-6-methoxyquinolines: Key building blocks for the synthesis of antibiotics

      Flagstad, T., Petersen, M. T., Hinnerfeldt, D. M., Givskov, Michael & Nielsen, Thomas Eiland, 28 Aug 2014, In: Synthesis (Germany). 46, 23, p. 3263-3267 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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