Niels Høiby

Niels Høiby

Professor, No job title

Member of:


    1. 2012
    2. Published

      Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response

      Johansen, Helle Krogh, Aanæs, Kasper, Pressler, T., Nielsen, Kim G., Fisker, J., Skov, M., Høiby, Niels & von Buchwald, Christian, Dec 2012, In: Journal of Cystic Fibrosis. 11, 6, p. 525-531 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Treatment of lung infection in patients with cystic fibrosis: current and future strategies

      Döring, G., Flume, P., Heijerman, H., Elborn, J. S. & Consensus Study Group, C. S. G., Dec 2012, In: Journal of Cystic Fibrosis. 11, 6, p. 461-479 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis

      Cramer, N., Wiehlmann, L., Ciofu, Oana, Tamm, S., Høiby, Niels & Tümmler, B., Nov 2012, In: PLOS ONE. 7, 11, e50731.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo

      van Gennip, M., Hultqvist, Louise Dahl, Alhede, M., Qvortrup, Klaus, Jensen, Peter Østrup, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Aug 2012, In: Infection and Immunity. 80, 8, p. 2601-2607 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

      Marvig, R. L., Søndergaard, M. S. R., Damkiær, S., Høiby, Niels, Johansen, Helle Krogh, Molin, S. & Jelsbak, L., Aug 2012, In: Antimicrobial Agents and Chemotherapy. 56, 8, p. 4519-4521 3 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition

      Alhede, M., Qvortrup, Klaus, Liebrechts, R., Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 335-342 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections

      Ciofu, Oana, Mandsberg, L. F., Wang, H. & Høiby, Niels, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa

      Yang, L., Hengzhuang, W., Wu, H., Damkiaer, S., Jochumsen, N., Song, Z., Givskov, Michael, Høiby, Niels & Molin, S., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 366-376 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      Towards diagnostic guidelines for biofilm-associated infections

      Hall-Stoodley, L., Stoodley, P., Kathju, S., Høiby, Niels, Moser, Claus Ernst, William Costerton, J., Moter, A. & Bjarnsholt, Thomas, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 127-145 19 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Understanding biofilms - Are we there yet?

      Bjarnsholt, Thomas, Høiby, Niels, Donelli, G., Imbert, C. & Försberg, A., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 125-126 2 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Process for the manufacture of ajoene derivatives

      Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

      Research output: Patent

    13. Published

      A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production

      Sautter, R., Ramos, D., Schneper, L., Ciofu, Oana, Wassermann, T., Koh, C., Heydorn, A., Hentzer, M., Høiby, Niels, Kharazmi, A., Molin, S., Devries, C. A., Ohman, D. E. & Mathee, K., 1 May 2012, In: Gene. 498, 2, p. 242-253 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

      Jakobsen, Tim Holm, van Gennip, M., Phipps, R. K., Shanmugham, M. S., Hultqvist, Louise Dahl, Alhede, M., Skindersoe, M. E., Rasmussen, T. B., Friedrich, K., Uthe, F., Jensen, Peter Østrup, Moser, Claus Ernst, Nielsen, Kristian Fog, Eberl, L., Larsen, T. O., Tanner, D. A., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2314-25 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2683-2690 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

      Christensen, L., van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael & Alhede, M., May 2012, In: The Journal of antimicrobial chemotherapy. 67, 5, p. 1198-206 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients

      Moskowitz, S. M., Brannon, M. K., Dasgupta, N., Pier, M., Sgambati, N., Miller, A. K., Selgrade, S. E., Miller, S. I., Denton, M., Conway, S. P., Johansen, Helle Krogh & Høiby, Niels, Feb 2012, In: Antimicrobial Agents and Chemotherapy. 56, 2, p. 1019-1030 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection

      Christophersen, L. J., Trøstrup, H., Damlund, D. S. M., Bjarnsholt, Thomas, Thomsen, K., Jensen, Peter Østrup, Hougen, H. P., Høiby, Niels & Moser, Claus Ernst, 2012, In: Experimental and clinical endocrinology. 170, 2, p. 222-30 10 p., 170.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Combating biofilms

      Yang, L., Liu, Y., Wu, H., Song, Z., Høiby, Niels, Molin, S. & Givskov, Michael, 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 146–157

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Culture-dependent and -independent investigations of microbial diversity on urinary catheters

      Xu, Y., Moser, Claus Ernst, Abu Al-Soud, W., Sørensen, Søren Johannes, Høiby, Niels, Nielsen, P. H. & Thomsen, T. R., 2012, In: Journal of Clinical Microbiology. 50, 12, p. 3901-3908 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      Evolution and diversification of Pseudomonas aeruginosa in the paranasal sinuses of cystic fibrosis children have implications for chronic lung infection

      Hansen, S. K., Rau, M. H., Johansen, Helle Krogh, Ciofu, Oana, Jelsbak, L., Yang, L., Folkesson, A., Jarmer, H. Ø., Aanæs, Kasper, von Buchwald, Christian, Høiby, Niels & Molin, S., 2012, In: I S M E Journal. 6, 1, p. 31-45

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Extensive endoscopic image-guided sinus surgery decreases BPI-ANCA in patients with cystic fibrosis

      Aanæs, Kasper, Rasmussen, N., Pressler, T., Segelmark, M., Johansen, Helle Krogh, Lindberg, U., Høiby, Niels, Carlsson, M., Wieslander, J. & Buchwald, C., 2012, In: Scandinavian Journal of Immunology. 76, 6, p. 573-9 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa

      Jakobsen, Tim Holm, Bragason, S. K., Phipps, R. K., Hultqvist, Louise Dahl, van Gennip, M., Alhede, M., Skindersoe, M., Larsen, T. O., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Applied and Environmental Microbiology. 78, 7, p. 2410-2421 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis

      Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    25. Published

      Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in Guinea Pigs

      Jensen, Peter Østrup, Lykkesfeldt, Jens, Bjarnsholt, Thomas, Hougen, H. P., Høiby, Niels & Ciofu, Oana, 2012, In: Basic & Clinical Pharmacology & Toxicology. 110, 4, p. 353-358 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization

      Aanæs, Kasper, Johansen, Helle Krogh, Poulsen, Steen Seier, Pressler, T., Buchwald, C. & Høiby, Niels, 2012, In: Journal of Cystic Fibrosis. 12, 1, p. 81-87 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorom sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model.

      Hultqvist, Louise Dahl, van Gennip, M., Jakobsen, Tim Holm, Alhede, M., Hougen, H. P., Høiby, Niels, Bjarnsholt, Thomas & Givskov, Michael, 2012, In: Journal of Antimicrobial Chemotherapy. 67, 5, p. 1198-1206 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. 2011
    29. Published

      PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients

      Miller, A. K., Brannon, M. K., Stevens, L., Johansen, Helle Krogh, Selgrade, S. E., Miller, S. I., Høiby, Niels & Moskowitz, S. M., 3 Oct 2011, In: Antimicrobial Agents and Chemotherapy. 55, 12, p. 5761-5769

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Chronic pulmonary infection with Stenotrophomonas maltophilia and lung function in patients with cystic fibrosis

      Dalbøge, C. S., Hansen, C. R., Pressler, T., Høiby, Niels & Johansen, Helle Krogh, 1 Sep 2011, In: Journal of Cystic Fibrosis. 10, 5, p. 318-25 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, 1 Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z., Høiby, Niels & Wang, H., Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      Detection of microbial diversity in endocarditis using cultivation-independent molecular techniques

      Wolff, T. Y., Moser, Claus Ernst, Bundgaard, H., Høiby, Niels, Nielsen, P. H. & Thomsen, T. R., 26 Aug 2011, In: Scandinavian Journal of Infectious Diseases. 43, 11-12, p. 857-869

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Pattern differentiation in co-culture biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa

      Yang, L., Liu, Y., Markussen, T., Høiby, Niels, Tolker-Nielsen, Tim & Molin, S., 1 Aug 2011, In: F E M S Immunology and Medical Microbiology. 62, 3, p. 339-47 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    35. Published

      Effects of Photoactivated Titanium Dioxide Nanopowders and Coating on Planktonic and Biofilm Growth of Pseudomonas aeruginosa

      Polo, A., Diamanti, M. V., Bjarnsholt, Thomas, Høiby, Niels, Villa, F., Pedeferri, M. P. & Cappitelli, F., 25 Jul 2011, In: Photochemistry and Photobiology.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      The microorganisms in chronically infected end-stage and non-end-stage cystic fibrosis patients

      Rudkjøbing, V. B., Thomsen, T. R., Alhede, M., Kragh, K. N., Nielsen, P. H., Johansen, U. R., Givskov, Michael, Høiby, Niels & Bjarnsholt, Thomas, Jul 2011, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 236-244 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Chronic Pseudomonas aeruginosa infection definition: EuroCareCF Working Group report

      Pressler, T., Bohmova, C., Conway, S., Dumcius, S., Hjelte, L., Høiby, Niels, Kollberg, H., Tümmler, B. & Vavrova, V., 1 Jun 2011, In: Journal of Cystic Fibrosis. 10 Suppl 2, p. S75-8

      Research output: Contribution to journalJournal articleResearchpeer-review

    38. Published

      Effects of ginseng on Pseudomonas aeruginosa motility and biofilm formation

      Wu, H., Lee, B., Yang, L., Wang, H., Givskov, Michael, Molin, S., Høiby, Niels & Song, Z., 1 Jun 2011, In: F E M S Immunology and Medical Microbiology. 62, 1, p. 49-56 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Evolutionary dynamics of bacteria in a human host environment

      Yang, L., Jelsbak, L., Marvig, R. L., Damkiær, S., Workman, C., Rau, M. H., Hansen, S. K., Folkesson, A., Johansen, Helle Krogh, Ciofu, Oana, Høiby, Niels, Sommer, M. & Molin, S., 3 May 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 18, p. 7481-6 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Current understanding of multi-species biofilms

      Yang, L., Liu, Y., Wu, H., Høiby, Niels, Molin, S. & Song, Z., 1 Apr 2011, In: International Journal of Oral Science. 3, 2, p. 74-81 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Bacterial adaptation during chronic infection revealed by independent component analysis of transcriptomic data

      Yang, L., Rau, M. H., Yang, L., Høiby, Niels, Molin, S. & Jelsbak, L., 1 Jan 2011, In: B M C Microbiology. 11, p. 184

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

      Høiby, Niels, 1 Jan 2011, In: B M C Medicine. 9, p. 32

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients

      Høiby, Niels, Johansen, Helle Krogh, Moser, Claus Ernst, Ciofu, Oana, Jensen, Peter Østrup, Kolpen, Mette, Mandsberg, L., Givskov, Michael, Molin, S. & Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer, p. 167-184 18 p.

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

    44. Published

      Anaerobic bacteria in biofilm –and their tolerance to antibiotics

      Kragh, K. N., Kühl, Michael, Gregersen, A., Tvede, M., Høiby, Niels & Bjarnsholt, Thomas, 2011.

      Research output: Contribution to conferencePosterResearch

    45. Published

      Biofilm infections

      Bjarnsholt, Thomas, Moser, Claus Ernst, Jensen, Peter Østrup & Høiby, Niels, 2011, Springer New York. 314 p.

      Research output: Book/ReportBookResearchpeer-review

    46. Published

      Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

      Aanæs, Kasper, Rickelt, L. F., Johansen, Helle Krogh, von Buchwald, Christian, Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2011, In: Journal of Cystic Fibrosis. 10, 2, p. 114-120 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM)

      Mandsberg, L. F., Maciá, M. D., Bergmann, K. R., Christiansen, L., Alhede, M., Kirkby, N., Høiby, Niels, Oliver, A. & Ciofu, Oana, 2011, In: F E M S Microbiology Letters. 324, 1, p. 28-37 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Hvad er stafylokokker?

      Høiby, Niels, 2011

      Research output: Other contributionNet publication - Internet publicationResearch

    49. Published

      Methods to classify bacterial pathogens in cystic fibrosis

      Bjarnsholt, Thomas, Nielsen, X. C., Johansen, U., Nørgaard, L. & Høiby, Niels, 2011, In: Methods in Molecular Biology. 742, p. 143-71 29 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

      Lee, B., Schjerling, C. K., Kirkby, N., Hoffmann, N., Borup, R., Molin, S., Høiby, Niels & Ciofu, Oana, 2011, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 119, 4-5, p. 263-74 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    51. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      Prevention of biofilm formation in the soft tissue filler Aquamid

      Er, Ö., Kühl, Michael, Tvede, M., Høiby, Niels, Nielsen, A. K. & Bjarnsholt, Thomas, 2011.

      Research output: Contribution to conferencePosterResearchpeer-review

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