Niels Høiby

Niels Høiby

Professor, No job title

Member of:


    1. Published

      Pengene eller livet. Det politiske ansvar for sundhedsvæsenets nedtur.

      Høiby, Niels, 2001, Ashehougs Forlag.

      Research output: Book/ReportBookResearchpeer-review

    2. Published

      Pharmacokinetic variability of clarithromycin and differences in CYP3A4 activity in patients with cystic fibrosis

      Dalbøge, C. S., Nielsen, X. C., Dalhoff, K., Alffenaar, J. W., Duno, M., Buchard, Anders, Uges, D. R. A., Jensen, A. G., Jürgens, G., Pressler, T., Johansen, H. K. & Høiby, Niels, Mar 2014, In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 13, 2, p. 179-85 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo

      Hengzhuang, W., Høiby, Niels & Ciofu, Oana, 2014, In: Methods in molecular biology (Clifton, N.J.). 1147, p. 239-54 16 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. Published

      Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, 1 Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Pharmacokinetics/pharmacodynamics of colistin and imipenem on mucoid and nonmucoid Pseudomonas aeruginosa biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z., Høiby, Niels & Wang, H., Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Phenotype of non-attached Pseudomonas aeruginosa microclonies resembles attached biofilm, including reversible antibiotic tolerance

      Alhede, M., Qvortrup, K., Allesen-Holm, M., van Gennip, M., Christensen, L., Jensen, Peter Østrup, Nielsen, A., Tolker-Nielsen, T., Høiby, Niels, Givskov, M. C. & Bjarnsholt, Thomas, 2010. 0 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    7. Published

      Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

      Alhede, M., Kragh, K. N., Qvortrup, Klaus, Allesen-Holm, M., van Gennip, M., Hultqvist, Louise Dahl, Jensen, Peter Østrup, Nielsen, A. K., Parsek, M., Wozniak, D., Molin, S., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 2011, In: P L o S One. 6, 11, p. e27943

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections

      Ciofu, Oana, Mandsberg, L. F., Wang, H. & Høiby, Niels, Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 215-225 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. Published

      Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

      Fernandez-Barat, L., Ciofu, Oana, Kragh, K. N., Pressler, T., Johansen, U., Motos, A., Torres, A. & Høiby, Niels, Mar 2017, In: Journal of Cystic Fibrosis. 16, 2, p. 222-229

      Research output: Contribution to journalJournal articleResearchpeer-review

    10. Published

      PhoQ mutations promote lipid A modification and polymyxin resistance of Pseudomonas aeruginosa found in colistin-treated cystic fibrosis patients

      Miller, A. K., Brannon, M. K., Stevens, L., Johansen, Helle Krogh, Selgrade, S. E., Miller, S. I., Høiby, Niels & Moskowitz, S. M., 3 Oct 2011, In: Antimicrobial Agents and Chemotherapy. 55, 12, p. 5761-5769

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

      Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      Plasmid-borne AmpC beta-lactamase

      Walter-Rasmussen, J. & Høiby, Niels, 2002, In: Canadian Journal of Microbiology. 48, p. 479-493

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model

      Brinch, K. S., Sandberg, A., Baudoux, P., Van Bambeke, F., Tulkens, P. M., Frimodt-Møller, N., Høiby, Niels & Kristensen, H., 2009, In: Antimicrobial Agents and Chemotherapy. 53, 11, p. 4801-8 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients

      Moskowitz, S. M., Brannon, M. K., Dasgupta, N., Pier, M., Sgambati, N., Miller, A. K., Selgrade, S. E., Miller, S. I., Denton, M., Conway, S. P., Johansen, Helle Krogh & Høiby, Niels, Feb 2012, In: Antimicrobial Agents and Chemotherapy. 56, 2, p. 1019-1030 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. Published

      Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

      Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    16. Published

      Polymorphonuclear leukocytes and pseudomonas aeruginosa biofilm

      Kharazmi, A., Mathee, K., Jensen, E. T., Molin, S. & Høiby, Niels, 1999, In: Clinical Microbiology and Infection. 5, p. S27-S28

      Research output: Contribution to journalJournal articleResearchpeer-review

    17. Published

      Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients

      Kragh, K. N., Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In: Infection and Immunity. 82, 11, p. 4477-4486 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    18. Published

      Polysaccharides serve as scaffold of biofilms formed by mucoid Pseudomonas aeruginosa

      Yang, L., Hengzhuang, W., Wu, H., Damkiaer, S., Jochumsen, N., Song, Z., Givskov, Michael, Høiby, Niels & Molin, S., Jul 2012, In: F E M S Immunology and Medical Microbiology. 65, 2, p. 366-376 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    19. Published

      Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in Guinea Pigs

      Jensen, Peter Østrup, Lykkesfeldt, Jens, Bjarnsholt, Thomas, Hougen, H. P., Høiby, Niels & Ciofu, Oana, 2012, In: Basic & Clinical Pharmacology & Toxicology. 110, 4, p. 353-358 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    20. Published

      Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective Endocarditis

      Lerche, C. J., Schwartz, F., Pries-Heje, M. M., Fosbøl, E. L., Iversen, Kasper, Jensen, Peter Østrup, Høiby, Niels, Hyldegaard, Ole, Bundgård, Henning & Moser, Claus Ernst, 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 805964.

      Research output: Contribution to journalReviewResearchpeer-review

    21. Published

      Preclinical in vitro and in vivo characterization of the fully human monoclonal IgM antibody KBPA101 specific for Pseudomonas aeruginosa serotype IATS-O11

      Horn, M. P., Zuercher, A. W., Imboden, M. A., Rudolf, M. P., Lazar, H., Wu, H., Høiby, Niels, Fas, S. C. & Lang, A. B., 1 Jun 2010, In: Antimicrobial Agents and Chemotherapy. 54, 6, p. 2338-44 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Prehospital diagnostic and therapeutic management of otogenic Streptococcus pneumoniae meningitis

      Ostergaard, C., Høiby, Niels, Konradsen, H. B. & Samuelsson, S., 2006, In: Scandinavian Journal of Infectious Diseases. 38, 3, p. 172-180 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Prevention of biofilm formation in the soft tissue filler Aquamid

      Er, Ö., Kühl, Michael, Tvede, M., Høiby, Niels, Nielsen, A. K. & Bjarnsholt, Thomas, 2011.

      Research output: Contribution to conferencePosterResearchpeer-review

    24. Published

      Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

      Arndal, E., Johansen, Helle Krogh, Haagensen, J. A. J., Bartell, J. A., Marvig, R. L., Alanin, M., Aanæs, Kasper, Høiby, Niels, Nielsen, Kim G., Backer, Vibeke & von Buchwald, Christian, 2020, In: The European Respiratory Journal. 55, 1, 4 p., 1901472.

      Research output: Contribution to journalLetterResearchpeer-review

    25. Published

      Process for the manufacture of ajoene derivatives

      Bjarnsholt, Thomas, Høiby, Niels, Jensen, Peter Østrup, Phipps, R., Shanmugham, Meenakshi, S., Alhede, M., Hultqvist, Louise Dahl, Jakobsen, Tim Holm, Tanner, D., Larsen, Thomas, O. & Givskov, Michael, 14 Jun 2012, IPC No. C07C 323/ 65 A I, Patent No. WO2012076016, Priority date 8 Dec 2010, Priority No. EP20100194154

      Research output: Patent

    26. Published

      Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis

      Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: F E M S Microbiology Letters. 184, 2, p. 273-8 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. Published

      Production of N-acyl-L-homoserine lactones by Pseudomonas aeruginosa isolates from chronic lung infections associated with cystic fibrosis

      Geisenberger, O., Givskov, Michael, Riedel, K., Høiby, Niels, Tümmler, B. & Eberl, L., 2000, In: FEMS Microbiology Letters. 184, p. 273-278

      Research output: Contribution to journalJournal articleResearchpeer-review

    28. Published

      Prospects for the prevention and control of Pseudomonal colinization in children with cystic fibrosis

      Høiby, Niels, 2000, In: Pediatric Drugs. 2, p. 451-463

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      Prosthesis infections after orthopedic joint replacement: the possible role of bacterial biofilms

      Song, Z., Borgwardt, L., Høiby, Niels, Wu, H., Sørensen, T. S. & Borgwardt, A., 7 Jun 2013, In: Orthopedic Reviews. 5, 2, p. 65-71 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Pseudomonas aeruginosa alginate is refractory to Th1 immune response and impedes host immune clearance in a mouse model of acute lung infection.

      Song, Z., Wu, H., Ciofu, Oana, Kong, K., Høiby, Niels, Rygaard, J., Kharazmi, A. & Mathee, K., 2003, In: Journal of Medical Microbiology. 52, Pt 9, p. 731-40 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.

      Høiby, Niels, Johansen, Helle Krogh, Moser, C., Song, Z., Ciofu, Oana & Kharazmi, A., 2001, In: Microbes and Infection. 3, 1, p. 23-35 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Pseudomonas aeruginosa antibody response in cystic fibrosis decreases rapidly following lung transplantation

      Schwensen, H. F., Moser, Claus Ernst, Perch, Michael, Pressler, T. & Høiby, Niels, 2020, In: Journal of Cystic Fibrosis. 19, 4, p. 587-594

      Research output: Contribution to journalJournal articleResearchpeer-review

    33. Published

      Pseudomonas aeruginosa biofilm aggravates skin inflammatory response in BALB/c mice in a novel chronic wound model

      Trøstrup, H., Thomsen, K., Christophersen, L. J., Hougen, H. P., Bjarnsholt, Thomas, Jensen, Peter Østrup, Kirkby, N., Calum, H., Høiby, Niels & Moser, Claus Ernst, Mar 2013, In: Wound Repair and Regeneration. 21, 2, p. 292-299 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Pseudomonas aeruginosa biofilm infection in the smaller airways of BALB/c mice exacerbates pulmonary inflammation.

      Christophersen, L. J., Bjarnsholt, Thomas, Jensen, Peter Østrup, Damlund, D., Høiby, Niels & Moser, Claus Ernst, 2010. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

    35. Published

      Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies

      Hassett, D. J., Korfhagen, T. R., Irvin, R. T., Schurr, M. J., Sauer, K., Lau, G. W., Sutton, M. D., Yu, H. & Høiby, Niels, 1 Feb 2010, In: Expert Opinion On Therapeutic Targets. 14, 2, p. 117-30 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    36. Published

      Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

      Bagge, N., Schuster, M., Hentzer, M., Ciofu, Oana, Givskov, Michael, Greenberg, E. P. & Høiby, Niels, 2004, In: Antimicrobial Agents and Chemotherapy. 48, 4, p. 1175-87 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    37. Published

      Pseudomonas aeruginosa biofilms in cystic fibrosis

      Høiby, Niels, Ciofu, Oana & Bjarnsholt, Thomas, 1 Nov 2010, In: Future Microbiology. 5, p. 1663-74 12 p.

      Research output: Contribution to journalReviewResearchpeer-review

    38. Published

      Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Fiandaca, M. J., Pedersen, J., Hansen, C. R., Andersen, C. B., Pressler, T., Givskov, Michael & Høiby, Niels, 1 Jun 2009, In: Pediatric Pulmonology. 44, 6, p. 547-58 12 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    39. Published

      Pseudomonas aeruginosa diversity in distinct paediatric patient groups

      Tramper-Stranders, G. A., Ent, C. K. V. D., Wolfs, T. F., Kimpen, J. L., Fleer, A., Johansen, U., Høiby, Niels & Johansen, Helle Krogh, 2008, In: Clinical Microbiology and Infection. 14, 10, p. 935-941 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Pseudomonas aeruginosa infection in cystic fibrosis

      Høiby, Niels, 2007, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 115, 5, p. 621-628 7 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region.

      Campbell, J. I., Ciofu, Oana & Høiby, Niels, 1997, In: Antimicrobial Agents and Chemotherapy. 41, 6, p. 1380-4 4 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    42. Published

      Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection

      Wu, H., Song, Z., Givskov, Michael, Doring, G., Worlitzsch, D., Mathee, K., Rygaard, J. & Høiby, Niels, 2001, In: Microbiology. 147, Pt 5, p. 1105-1113 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth

      Kerr, J. R., Taylor, G. W., Rutman, A., Høiby, Niels, Cole, P. J. & Wilson, R., 1999, In: Journal of Clinical Pathology. 52, p. 385-387

      Research output: Contribution to journalJournal articleResearchpeer-review

    44. Published

      Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

      Bjarnsholt, Thomas, Jensen, P. Ø., Burmølle, M., Hentzer, M., Haagensen, J. A. J., Hougen, H. P., Calum, H., Madsen, K. G., Moser, C., Molin, S., Høiby, Niels & Givskov, M. C., 1 Feb 2005, In: Microbiology. 151, Pt 2, p. 373-83 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Pseudomonas mendocina as a cause of chronic infective endocarditis in a patient with situs inversus

      Johansen, Helle Krogh, Kjeldsen, K. & Høiby, Niels, 2001, In: Clinical Microbiology and Infection. 7, p. 650-652

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Quantitative analysis of the IgG and IgG subclass immune responses to chromosomal Pseudomonas aeruginosa beta-lactamase in serum from patients with cystic fibrosis by western blotting and laser scanning densitometry.

      Petersen, T. D., Ciofu, Oana, Pressler, T., Giwercman, B., Pedersen, S. S. & Høiby, Niels, 1996, In: Thorax. 51, 7, p. 733-8 5 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

      Bjarnsholt, Thomas, Jensen, Peter Østrup, Jakobsen, Tim Holm, Phipps, R., Nielsen, A. K., Rybtke, Morten Levin, Tolker-Nielsen, Tim, Givskov, Michael, Høiby, Niels, Ciofu, Oana & Scandinavian Cystic Fibrosis Study Consortium, S. C. F. S. C., 1 Jan 2010, In: PLoS ONE. 5, 4, p. e10115

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. Published

      Quorum sensing in Gram-negative bacteria

      Wu, H., Song, Z., Høiby, Niels & Givskov, Michael, May 2004, In: Progress in Natural Science. 14, 5, p. 377-387 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    49. Published

      Quorum sensing systems contribute to the severity of the lung infection of pseudomonas aeruginosa in rats

      Wu, H., Song, Z. J., Givskov, Michael, Mathee, K., Rygaard, J. & Høiby, Niels, 1999, In: Pediatric Pulmonology. Suppl 19, p. 269-269

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT

      Kolpen, Mette, Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.

      Research output: Contribution to journalConference abstract in journalResearchpeer-review

    ID: 8427