Oana Ciofu

Oana Ciofu

Professor

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    ORCID: 0000-0001-5648-4858

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    1. Published

      Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

      Hengzhuang, W., Wu, H., Ciofu, Oana, Song, Z. & Høiby, Niels, 1 Sep 2011, In: Antimicrobial Agents and Chemotherapy. 55, 9, p. 4469-74 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      P. aeruginosa flow-cell biofilms are enhanced by repeated phage treatments but can be eradicated by phage-ciprofloxacin combination: —monitoring the phage–P. aeruginosa biofilms interactions

      Henriksen, K., Rørbo, N., Rybtke, Morten Levin, Martinet, M. G., Tolker-Nielsen, Tim, Høiby, Niels, Middelboe, Mathias & Ciofu, Oana, 2019, In: Pathogens and Disease. 77, 2, 11 p., ftz011.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      In vivo evolution of antimicrobial resistance in a biofilm model of Pseudomonas aeruginosa lung infection

      Higazy, Doaa Mohamed Mohamed E, Pham, A. D., van Hasselt, C., Høiby, Niels, Jelsbak, L., Moser, Claus Ernst & Ciofu, Oana, 2024, In: The ISME Journal. 18, 1

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Erratum: Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis (Infection and Immunity (2005) 73, 4 (2504-2514))

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, Aug 2005, In: Infection and Immunity. 73, 8, p. 5290 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    5. Published

      Novel mouse model of chronic Pseudomonas aeruginosa lung infection mimicking cystic fibrosis

      Hoffmann, N., Rasmussen, T. B., Jensen, Peter Østrup, Stub, C., Hentzer, M., Molin, S., Ciofu, Oana, Givskov, Michael, Johansen, Helle Krogh & Høiby, Niels, 2005, In: Infection and Immunity. 73, 4, p. 2504-14 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Use of carbapenems and other antibiotics for pulmonary infections in patients with cystic fibrosis.

      Høiby, Niels, Ciofu, Oana, Jensen, T., Pressler, T., Johansen, Helle Krogh & Koch, C., 1996, In: Pediatric Infectious Disease Journal. 15, 8, p. 738-43 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.

      Høiby, Niels, Johansen, Helle Krogh, Moser, C., Song, Z., Ciofu, Oana & Kharazmi, A., 2001, In: Microbes and Infection. 3, 1, p. 23-35 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Diagnosis of biofilm infections in cystic fibrosis patients

      Høiby, Niels, Bjarnsholt, Thomas, Moser, Claus Ernst, Jensen, Peter Østrup, Kolpen, Mette, Qvist, T., Aanæs, Kasper, Pressler, T., Skov, M. & Ciofu, Oana, Apr 2017, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 125, 4, p. 339-343 5 p.

      Research output: Contribution to journal › Review › Research › peer-review

    9. Published

      A master of adaptation and survival strategies

      Høiby, Niels, Johansen, H. K., Moser, C., Ciofu, Oana & Rehm, B. H. A., 2008, Pseudomonas. Model Organism, Pathogen, Cell Factory. Weinheim: Wiley-VCH, Vol. 2. p. 25-44 19 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    10. Published

      Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients

      Høiby, Niels, Johansen, Helle Krogh, Moser, Claus Ernst, Ciofu, Oana, Jensen, Peter Østrup, Kolpen, Mette, Mandsberg, L., Givskov, Michael, Molin, S. & Bjarnsholt, Thomas, 2011, Biofilm Infections. Springer, p. 167-184 18 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    11. Published

      The clinical impact of bacterial biofilms

      Høiby, Niels, Ciofu, Oana, Johansen, Helle Krogh, Song, Z., Moser, Claus Ernst, Jensen, Peter Østrup, Molin, S., Givskov, Michael, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2011, In: International Journal of Oral Science. 3, 2, p. 55-65

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Fremmedlegemeinfektioner--nyt om biofilm og quorum sensing.

      Høiby, Niels, Johansen, Helle Krogh, Ciofu, Oana, Jensen, Peter Østrup, Bjarnsholt, Thomas & Givskov, Michael, 2007, In: Ugeskrift for læger. 169, 48, p. 4163-6 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Formation of Pseudomonas aeruginosa inhibition zone during tobramycin disk diffusion is due to transition from planktonic to biofilm mode of growth

      Høiby, Niels, Henneberg, K. Å., Wang, H., Stavnsbjerg, Camilla, Bjarnsholt, Thomas, Ciofu, Oana, Johansen, U. R. & Sams, T., 2019, In: International Journal of Antimicrobial Agents. 53, 5, p. 564-573

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Kompendium i mikrobiologi og infektionsmedicin

      Høiby, N., Skinhøj, P., Andersen, Å. B., Andersen, Leif Percival, Arendrup, M. C., Christiansen, C. B., Ciofu, Oana, Gerstoft, Jan, Johansen, Helle Krogh, Kemp, M., Kurtzhals, Jørgen, Nielsen, L. P., Lyngsøe Svejgaard, E., Theander, Thor Grundtvig & Thomsen, Allan Randrup, 2015, 1. ed. FADL's Forlag.

      Research output: Book/Report › Book › Education

    15. Published

      Generel bakteriologi

      Høiby, Niels, Ciofu, Oana, Johansen, H. K., Andersen, L. P. & Skinhøj, P., 2008, Klinisk Mikrobiologi og Infektionsmedicin. 3rd ed. København: FADL's Forlag, Vol. 4. p. 21-107 86 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    16. Published

      Pseudomonas aeruginosa biofilms in cystic fibrosis

      Høiby, Niels, Ciofu, Oana & Bjarnsholt, Thomas, 1 Nov 2010, In: Future Microbiology. 5, p. 1663-74 12 p.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      Antibiotic resistance of bacterial biofilms

      Høiby, Niels, Bjarnsholt, Thomas, Givskov, Michael, Molin, S. & Ciofu, Oana, 2010, In: International Journal of Antimicrobial Agents. 35, 4, p. 322-332 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      Chromosomal mechanisms of aminoglycoside resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients

      Islam, S., Oh, H., Jalal, S., Karpati, F., Ciofu, Oana, Høiby, Niels & Wretlind, B., 2009, In: Clinical Microbiology and Infection. 15, 1, p. 60-6 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes

      Jakobsen, T. H., Hansen, M. A., Jensen, P. Ø., Hansen, L., Riber, L., Cockburn, A. P. I., Kolpen, M., Hansen, C. R., Ridderberg, W., Eickhardt-Sørensen, S. R., Hansen, M., Kerpedjiev, P., Alhede, M., Qvortrup, K., Burmølle, M., Moser, C. E., Kühl, M., Ciofu, O., Givskov, M., Sørensen, S. J. & 2 others, Høiby, Niels & Bjarnsholt, Thomas, 2013, In: P L o S One. 8, 7, 17 p., e68484.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.

      Jalal, S., Ciofu, Oana, Høiby, Niels, Gotoh, N. & Wretlind, B., 2000, In: Antimicrobial Agents and Chemotherapy. 44, 3, p. 710-2 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Molecular epidemiology and dynamics of Pseudomonas aeruginosa populations in lungs of cystic fibrosis patients.

      Jelsbak, L., Johansen, Helle Krogh, Frost, A., Thøgersen, R., Thomsen, Line Elnif, Ciofu, Oana, Yang, L., Haagensen, J. A. J., Høiby, Niels & Molin, S., 2007, In: Infection and Immunity. 75, 5, p. 2214-24 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

      Jensen, Peter Østrup, Møller, S. A., Lerche, C. J., Moser, Claus Ernst, Bjarnsholt, Thomas, Ciofu, Oana, Faurholt-Jepsen, Daniel, Høiby, Niels & Kolpen, Mette, 2019, In: Biofilm. 1, 4 p., 100008.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Poor antioxidant status exacerbates oxidative stress and inflammatory response to Pseudomonas aeruginosa lung infection in Guinea Pigs

      Jensen, Peter Østrup, Lykkesfeldt, Jens, Bjarnsholt, Thomas, Hougen, H. P., Høiby, Niels & Ciofu, Oana, 2012, In: Basic & Clinical Pharmacology & Toxicology. 110, 4, p. 353-358 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms

      Jensen, Peter Østrup, Briales, A., Brochmann, R. P., Wang, H., Kragh, K. N., Kolpen, Mette, Hempel, C., Bjarnsholt, Thomas, Høiby, Niels & Ciofu, Oana, 2014, In: Pathogens and Disease. 70, 3, p. 440-443 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients.

      Johansen, Helle Krogh, Moskowitz, S. M., Ciofu, Oana, Pressler, T. & Høiby, Niels, 2008, In: Journal of Cystic Fibrosis. 7, 5, p. 391-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Diversity of metabolic profiles of cystic fibrosis Pseudomonas aeruginosa during the early stages of lung infection

      Jorgensen, K. M., Wassermann, T., Johansen, Helle Krogh, Christiansen, L. E., Molin, S., Høiby, Niels & Ciofu, Oana, Jul 2015, In: Microbiology. 161, 7, p. 1447-1462 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Sublethal ciprofloxacin treatment leads to rapid development of high-level ciprofloxacin resistance during long-term experimental evolution of Pseudomonas aeruginosa

      Jørgensen, K. M., Wassermann, T., Jensen, Peter Østrup, Hengzuang, W., Molin, S., Høiby, Niels & Ciofu, Oana, Sep 2013, In: Antimicrobial Agents and Chemotherapy. 57, 9, p. 4215-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT

      Kolpen, Mette, Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    29. Published

      Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment

      Kolpen, Mette, Mousavi, N., Sams, T., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2016, In: International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    30. Published

      Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin

      Kolpen, Mette, Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

      Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions

      Kolpen, Mette, Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In: Pathogens and Disease. 74, 1, 7 p., ftv086.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Anvendelse af antibiotika i tandlægepraksis

      Larsen, Tove, Ciofu, Oana, Moesby, L., Kirkevang, L. & Havemose-Poulsen, A., Sep 2013, In: Tandlaegebladet. 117, 9, p. 718-729 12 p., 460.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in Pseudomonas aeruginosa in a Murine Biofilm Wound Model

      Laulund, A. S., Schwartz, F., Trøstrup, H., Thomsen, K., Christophersen, L., Calum, Henrik Pierre, Ciofu, Oana, Høiby, Niels & Moser, Claus Ernst, 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 652012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

      Lee, B., Schjerling, C. K., Kirkby, N., Hoffmann, N., Borup, R., Molin, S., Høiby, Niels & Ciofu, Oana, 2011, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 119, 4-5, p. 263-74 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Heterogeneity of biofilms formed by nonmucoid Pseudomonas aeruginosa isolates from patients with cystic fibrosis.

      Lee, B., Haagensen, J. A. J., Ciofu, Oana, Andersen, Jens Bo, Høiby, Niels & Molin, S., 2005, In: Journal of Clinical Microbiology. 43, 10, p. 5247-55 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum

      Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs

      Luján, A. M., Paterson, S., Hesse, E., Sommer, L. M., Marvig, R. L., Sharma, M. D., Alseth, E. O., Ciofu, Oana, Smania, A. M., Molin, S., Johansen, Helle Krogh & Buckling, A., 2022, In: Nature Ecology and Evolution. 6, p. 979–988

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Immunisation in the current management of cystic fibrosis patients.

      Malfroot, A., Adam, G., Ciofu, Oana, Döring, G., Knoop, C., Lang, A. B., Van Damme, P., Dab, I., Bush, A. & European Cystic Fibrosis Society (ECFS) Vaccination Group, E. C. F. S. (. V. G., 2005, In: Journal of Cystic Fibrosis. 4, 2, p. 77-87 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system

      Mandsberg, L. F., Ciofu, Oana, Kirkby, N., Christiansen, L. E., Poulsen, Henrik Enghusen, Høiby, Niels, Mandsberg, L. F., Ciofu, O., Kirkby, N., Christiansen, L. E., Poulsen, Henrik Enghusen & Høiby, N., 1 Jun 2009, In: Antimicrobial Agents and Chemotherapy. 53, 6, p. 2483-91 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM)

      Mandsberg, L. F., Maciá, M. D., Bergmann, K. R., Christiansen, L., Alhede, M., Kirkby, N., Høiby, Niels, Oliver, A. & Ciofu, Oana, 2011, In: F E M S Microbiology Letters. 324, 1, p. 28-37 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Within-host microevolution of Pseudomonas aeruginosa in Italian cystic fibrosis patients

      Marvig, R. L., Dolce, D., Sommer, L. M., Petersen, Bent, Ciofu, Oana, Campana, S., Molin, S., Taccetti, G. & Johansen, Helle Krogh, 19 Oct 2015, In: B M C Microbiology. 15, 13 p., 218.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.

      Mathee, K., Ciofu, Oana, Sternberg, C., Lindum, P. W., Campbell, J. I., Jensen, P., Johnsen, A. H., Givskov, Michael, Ohman, D. E., Molin, S., Høiby, Niels & Kharazmi, A., 1999, In: Microbiology. 145 ( Pt 6), p. 1349-57 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      IgG avidity to Pseudomonas aeruginosa over the course of chronic lung biofilm infection in cystic fibrosis

      Mauch, R. M., Nørregaard, L. L., Ciofu, Oana, Levy, C. E. & Høiby, Niels, 2018, In: Journal of Cystic Fibrosis. 17, 3, p. 356-359

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis

      Moser, C., Gennip, M. V., Bjarnsholt, Thomas, Jensen, Peter Østrup, Lee, B., Hougen, H. P., Calum, H., Ciofu, Oana, Givskov, Michael, Molin, S. & Høiby, Niels, 1 Feb 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 2, p. 95-107 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Antibiotic therapy as personalized medicine - general considerations and complicating factors

      Moser, Claus Ernst, Lerche, C. J., Thomsen, K., Hartvig, T., Schierbeck, J., Jensen, Peter Østrup, Ciofu, Oana & Høiby, Niels, 2019, In: APMIS. 127, 5, p. 361-371

      Research output: Contribution to journal › Review › Research › peer-review

    47. Published

      Novel experimental Pseudomonas aeruginosa infection model mimicking long-term host-pathogen interactions in cystic fibrosis.

      Moser, Claus Ernst, van Gennip, M., Bjarnsholt, Thomas, Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, Henrik Pierre, Ciofu, Oana, Givskov, Michael & Høiby, Niels, 2009, In: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 117, p. 95-107 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Hyperbaric oxygen treatment increases killing of aggregating Pseudomonas aeruginosa isolates from cystic fibrosis patients

      Møller, S. A., Jensen, Peter Østrup, Høiby, Niels, Ciofu, Oana, Kragh, K. N., Bjarnsholt, Thomas & Kolpen, Mette, 2019, In: Journal of Cystic Fibrosis. 18, 5, p. 657–664

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Genome sequence of Pseudomonas aeruginosa strain DK1-NH57388A, a stable mucoid cystic fibrosis isolate

      Norman, A., Ciofu, Oana, Amador, C. I., Høiby, Niels & Jelsbak, L., 2016, In: Genome Announcements. 4, 1, e00008-16.

      Research output: Contribution to journal › Journal article › Research

    50. Published

      Quantitative analysis of the IgG and IgG subclass immune responses to chromosomal Pseudomonas aeruginosa beta-lactamase in serum from patients with cystic fibrosis by western blotting and laser scanning densitometry.

      Petersen, T. D., Ciofu, Oana, Pressler, T., Giwercman, B., Pedersen, S. S. & Høiby, Niels, 1996, In: Thorax. 51, 7, p. 733-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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