Thomas Bjarnsholt
Professor
Bacteriology
Nørre Allé 14
2200 København N
- Published
Har ny teknologi overflødiggjort Grams farvemetode? Dansk Selskab for Klinisk Mikrobiologi
Johansen, Helle Krogh, Bjarnsholt, Thomas, Høiby, Niels & Dansk Selskab for Klinisk Mikrobiologi, D. S. F. K. M., 17 Mar 2008, In: Ugeskrift for læger. 170, 12, p. 1041Research output: Contribution to journal › Journal article › Research › peer-review
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Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis
Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilm and equine limb wounds
Jørgensen, Elin , Bjarnsholt, Thomas & Jacobsen, Stine, 2021, In: Animals. 11, 10, 2825.Research output: Contribution to journal › Review › Research › peer-review
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Histologic changes and gene expression patterns in biopsy specimens from bacteria-inoculated and noninoculated excisional body and limb wounds in horses healing by second intention
Jørgensen, Elin , Hjerpe, F. B., Hougen, H. P., Bjarnsholt, Thomas, Berg, Lise Charlotte & Jacobsen, Stine, 2020, In: American Journal of Veterinary Research. 81, 3, p. 276-284 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The occurrence of biofilm in an equine experimental wound model of healing by secondary intention
Jørgensen, Elin , Bay, Lene, Bjarnsholt, Thomas, Bundgaard, L., Sørensen, M. A. & Jacobsen, Stine, May 2017, In: Veterinary Microbiology. 204, p. 90-95 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An equine wound model to study effects of bacterial aggregates on wound healing
Jørgensen, Elin , Bay, Lene, Skovgaard, Lene Theil, Bjarnsholt, Thomas & Jacobsen, Stine, 2019, In: Advances in Wound Care. 8, 10, p. 487-498Research output: Contribution to journal › Journal article › Research › peer-review
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Staphylococcus aureus augments release of matrix metalloproteinase-8 from human polymorphonuclear leukocytes
Kirketerp-Møller, K., Bjarnsholt, Thomas, Jensen, Peter Østrup & Ågren, Magnus, 2020, In: Acta Dermato-Venereologica. 100, 15, p. 1-2 2 p., adv00232.Research output: Contribution to journal › Journal article › Research › peer-review
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Distribution, organization, and ecology of bacteria in chronic wounds
Kirketerp-Møller, K., Jensen, Peter Østrup, Fazli, M., Madsen, K. G., Pedersen, J., Moser, C., Tolker-Nielsen, Tim, Høiby, Niels, Givskov, Michael & Bjarnsholt, Thomas, 1 Aug 2008, In: Journal of Clinical Microbiology. 46, 8, p. 2717-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The zone model: A conceptual model for understanding the microenvironment of chronic wound infection
Kirketerp-Møller, K., Stewart, P. S. & Bjarnsholt, Thomas, 2020, In: Wound Repair and Regeneration. 28, 5, p. 593-599Research output: Contribution to journal › Journal article › Research › peer-review
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Eradication of biofilms on tympanostomy tubes with acetic acid treatment: an in vitro study
Kjeldsen, M., Homøe, Preben, Nielsen, Anne Kirstine, Crone, S., Nørskov Kragh, K. & Bjarnsholt, Thomas, 2020, In: APMIS. 128, 6, p. 445-450Research output: Contribution to journal › Journal article › Research › peer-review
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Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization
Knudsen, N. R., Rasmussen, A. K. I., Fiandaca, M. J., Kragh, K. N., Bjarnsholt, Thomas, Høiby, Niels, Stender, H. & Guardabassi, Luca, 2014, In: New Microbes and New Infections. 2, 3, p. 79-81 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial biofilms predominate in both acute and chronic human lung infections
Kolpen, Mette, Kragh, K. N., Enciso, J. B., Faurholt-Jepsen, D., Lindegaard, Birgitte, Egelund, G. B., Jensen, A. V., Ravn, P., Mathiesen, I. H. M., Gheorghe, Alexandra Gabriella, Hertz, Frederik Boëtius, Qvist, T., Whiteley, M., Jensen, Peter Østrup & Bjarnsholt, Thomas, 2022, In: European Respiratory Journal. Supplement. 60, Suppl. 66, 4.Research output: Contribution to journal › Journal article › Research › peer-review
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RE-SENSITIZATION OF ANOXIC PSEUDOMONAS AERUGINOSA BIOFILMS WITH RE-OXYGENATION USING HYPERBARIC OXYGEN TREATMENT
Kolpen, Mette, Mousavi, N., Sams, T., Kragh, K. N., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, P. O., Oct 2015, In: Pediatric Pulmonology. 50, S41, p. 312-312 1 p., 322.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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O-2 AFFECTS THE ACTIVITY OF AMIKACIN ON MYCOBACTERIUM ABSCESSUS BIOFILM
Kolpen, M., Ravnholt, C., Qvist, T., Kragh, K., Fritz, Blaine Gabriel, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Peter Østrup, Sep 2017, In: Pediatric Pulmonology. 52, S47, p. S359-S360 379.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Reinforcement of the bactericidal effect of ciprofloxacin on Pseudomonas aeruginosa biofilm by hyperbaric oxygen treatment
Kolpen, Mette, Mousavi, N., Sams, T., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2016, In: International Journal of Antimicrobial Agents. 47, 2, p. 163–167 5 p.Research output: Contribution to journal › Letter › Research › peer-review
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Hyperbaric oxygen sensitizes anoxic Pseudomonas aeruginosa biofilm to ciprofloxacin
Kolpen, Mette, Lerche, C. J., Kragh, K. N., Sams, T., Koren, K., Jensen, A. S., Line, L., Bjarnsholt, Thomas, Ciofu, Oana, Moser, Claus Ernst, Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, Nov 2017, In: Antimicrobial Agents and Chemotherapy. 61, 11, 9 p., e01024-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Nitric oxide production by polymorphonuclear leukocytes in sputum from cystic fibrosis patients with chronic lung infection
Kolpen, Mette, Bjarnsholt, Thomas, Moser, C., Hansen, C. R., Kühl, Michael, Høiby, Niels & Jensen, P. Ø., 2010, In: Journal of Cystic Fibrosis. Supplement 1, p. S49 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Nitric oxide production by polymorphonuclear leukocytes in infected cystic fibrosis sputum consumes oxygen
Kolpen, Mette, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Rickelt, L. F., Kühl, Michael, Hempel, C., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Clinical and Experimental Immunology. 177, 1, p. 310–319 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial biofilms predominate in both acute and chronic human lung infections
Kolpen, M., Kragh, K. N., Enciso, J. B., Faurholt-Jepsen, D., Lindegaard, Birgitte, Egelund, G. B., Jensen, A. V., Ravn, Pernille, Mathiesen, I. H. M., Gheorghe, Alexandra Gabriella, Hertz, Frederik Boëtius, Qvist, T., Whiteley, M., Jensen, Peter Østrup & Bjarnsholt, Thomas, 2022, In: Thorax. 77, p. 1015–1022Research output: Contribution to journal › Journal article › Research › peer-review
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Denitrification by cystic fibrosis pathogens - Stenotrophomonas maltophilia is dormant in sputum
Kolpen, Mette, Kragh, K. N., Bjarnsholt, Thomas, Line, L., Hansen, C. R., Dalbøge, C. S., Hansen, N., Kühl, Michael, Høiby, Niels & Jensen, Peter Østrup, 2015, In: International Journal of Medical Microbiology. 305, 1, p. 1-10 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Kolpen, Mette, Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus Ernst, Hansen, C. R., Liengaard, L., Kharazmi, A., Pressler, T., Høiby, Niels & Jensen, Peter Østrup, 2014, In: PLOS ONE. 9, 1, p. e84353 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis
Kolpen, Mette, Hansen, C. R., Bjarnsholt, Thomas, Moser, C., Hultqvist, Louise Dahl, van Gennip, M., Ciofu, Oana, Mandsberg, L., Kharazmi, A., Döring, G., Givskov, Michael, Høiby, Niels & Jensen, Peter Østrup, 1 Jan 2010, In: Thorax. 65, 1, p. 57-62 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biofilms of mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation
Kolpen, Mette, Jensen, Peter Østrup, Qvist, T., Kragh, K. N., Ravnholt, C., Fritz, Blaine Gabriel, Johansen, U. R., Bjarnsholt, Thomas & Høiby, Niels, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 2, e01212.Research output: Contribution to journal › Journal article › Research › peer-review
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Prevalence of biofilms in acute infections challenges a longstanding paradigm
Kolpen, M., Jensen, Peter Østrup, Faurholt-Jepsen, D. & Bjarnsholt, Thomas, 2022, In: Biofilm. 4, 100080.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased bactericidal activity of colistin on Pseudomonas aeruginosa biofilms in anaerobic conditions
Kolpen, Mette, Appeldorff, C. F., Brandt, S., Mousavi, N., Kragh, K. N., Aydogan, S., Uppal, H. A., Bjarnsholt, Thomas, Ciofu, Oana, Høiby, Niels & Jensen, Peter Østrup, Feb 2016, In: Pathogens and Disease. 74, 1, 7 p., ftv086.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of multicellular aggregates in biofilm formation
Kragh, K. N., Hutchison, J. B., Melaugh, G., Rodesney, C., Roberts, A. E. L., Irie, Y., Jensen, Peter Østrup, Diggle, S. P., Allen, R. J., Gordon, V. & Bjarnsholt, Thomas, 22 Mar 2016, In: mBio. 7, 2, 11 p., e00237-16.Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculation method could impact the outcome of microbiological experiments
Kragh, K. N., Alhede, M., Rybtke, Morten Levin, Stavnsbjerg, Camilla, Tolker-Nielsen, Tim, Whiteley, M. & Bjarnsholt, Thomas, 2018, In: Applied and Environmental Microbiology. 84, 5, 14 p., e02264-17.Research output: Contribution to journal › Journal article › Research › peer-review
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Into the well—A close look at the complex structures of a microtiter biofilm and the crystal violet assay
Kragh, K. N., Alhede, M., Kvich, Lasse Andersson & Bjarnsholt, Thomas, 2019, In: Biofilm. 1, 9 p., 100006.Research output: Contribution to journal › Journal article › Research › peer-review
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Polymorphonuclear leukocytes restrict growth of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients
Kragh, K. N., Alhede, M., Jensen, Peter Østrup, Moser, Claus Ernst, Scheike, Thomas, Jacobsen, C. S., Poulsen, Steen Seier, Eickhardt-Sørensen, S. R., Trostrup, H., Christoffersen, L., Hougen, H. P., Rickelt, L. F., Kühl, Michael, Høiby, Niels & Bjarnsholt, Thomas, 2014, In: Infection and Immunity. 82, 11, p. 4477-4486 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF-oprN efflux pump
Kristensen, Rasmus, Andersen, Jens Bo, Rybtke, Morten Levin, Jansen, C. U., Fritz, Blaine Gabriel, Kiilerich, R. O., Uhd, J., Bjarnsholt, Thomas, Qvortrup, K., Tolker-Nielsen, Tim, Givskov, Michael & Jakobsen, Tim Holm, 2024, In: Antimicrobial Agents and Chemotherapy. 68, 2Research output: Contribution to journal › Journal article › Research › peer-review
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The Pseudomonas aeruginosa autoinducer dodecanoyl-homoserine lactone inhibits the putrescine synthesis in human cells
Kristiansen, S., Bjarnsholt, Thomas, Adeltoft, D., Ifversen, P. & Givskov, Michael, 2008, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 116, 5, p. 361-371 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unexpected Diagnosis of Cerebral Toxoplasmosis by 16S and D2 Large-Subunit Ribosomal DNA PCR and Sequencing
Kruse, Alexandra Yasmin Collin, Kvich, Lasse Andersson, Eickhardt-Dalbøge, S. R., Omland, L. H., Bjarnsholt, Thomas & Moser, Claus Ernst, Jun 2015, In: Journal of Clinical Microbiology. 53, 6, p. 1983-1985 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incidence of Propionibacterium acnes in initially culture-negative thioglycollate broths: a prospective cohort study at a Danish University Hospital
Kvich, Lasse Andersson, Jensen, Peter Østrup, Justesen, U. S. & Bjarnsholt, Thomas, Nov 2016, In: Clinical Microbiology and Infection. 22, 11, p. 941-945Research output: Contribution to journal › Journal article › Research › peer-review
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The Combination of Low-Frequency Ultrasound and Antibiotics Improves the Killing of In Vitro Staphylococcus aureus and Pseudomonas aeruginosa Biofilms
Kvich, Lasse Andersson, Christensen, M. H., Pierchala, M. K., Astafiev, K., Lou-Moeller, R. & Bjarnsholt, Thomas, 2022, In: Antibiotics. 11, 11, 1494.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxygen restriction generates difficult-to-culture p. Aeruginosa
Kvich, Lasse Andersson, Fritz, Blaine Gabriel, Crone, S., Kragh, K. N., Kolpen, Mette, Sønderholm, M., Andersson, M., Koch, A., Jensen, Peter Østrup & Bjarnsholt, Thomas, 2019, In: Frontiers in Microbiology. 10, AUG, 15 p., 1992.Research output: Contribution to journal › Journal article › Research › peer-review
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Do Mixed-Species Biofilms Dominate in Chronic Infections? Need for in situ Visualization of Bacterial Organization
Kvich, Lasse Andersson, Burmølle, Mette, Bjarnsholt, Thomas & Lichtenberg, Mads, 2020, In: Frontiers in Cellular and Infection Microbiology. 10, 12 p., 396.Research output: Contribution to journal › Review › Research › peer-review
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Investigation of the mechanism and chemistry underlying Staphylococcus aureus' ability to inhibit Pseudomonas aeruginosa growth in vitro
Kvich, Lasse Andersson, Crone, S. G., Christensen, M. H., Lima, R. D. C. L., Alhede, M., Alhede, M., Stærk, Dan & Bjarnsholt, Thomas, 2022, In: Journal of Bacteriology. 204, 11, 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Single cells and bacterial biofilm populations in chronic wound infections
Lichtenberg, Mads, Kirketerp-Møller, K., Kvich, Lasse Andersson, Christensen, Mads Holm, Fritz, Blaine Gabriel, Jakobsen, Tim Holm & Bjarnsholt, Thomas, 2024, (E-pub ahead of print) In: APMIS.Research output: Contribution to journal › Journal article › Research › peer-review
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What's in a name? Characteristics of clinical biofilms
Lichtenberg, Mads, Coenye, T., Parsek, M. R., Bjarnsholt, Thomas & Jakobsen, Tim Holm, 2023, In: FEMS Microbiology Reviews. 47, 5, p. 1-8 fuad050.Research output: Contribution to journal › Review › Research › peer-review
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Nitric-oxide-driven oxygen release in anoxic Pseudomonas aeruginosa
Lichtenberg, Mads, Line, L., Schrameyer, V., Jakobsen, Tim Holm, Rybtke, Morten Levin, Toyofuku, M., Nomura, N., Kolpen, Mette, Tolker-Nielsen, Tim, Kühl, Michael, Bjarnsholt, Thomas & Jensen, Peter Østrup, 2021, In: iScience. 24, 12, 103404.Research output: Contribution to journal › Journal article › Research › peer-review
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Cyclic-di-GMP signaling controls metabolic activity in Pseudomonas aeruginosa
Lichtenberg, Mads, Kragh, K. N., Fritz, Blaine Gabriel, Kirkegaard, Julius Bier, Tolker-Nielsen, Tim & Bjarnsholt, Thomas, 2022, In: Cell Reports. 41, 3, p. 111515 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inoculum Concentration Influences Pseudomonas aeruginosa Phenotype and Biofilm Architecture
Lichtenberg, Mads, Kvich, Lasse Andersson, Larsen, S. L. B., Jakobsen, Tim Holm & Bjarnsholt, Thomas, 2022, In: Microbiology Spectrum. 10, 6Research output: Contribution to journal › Journal article › Research › peer-review
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The structure-function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment
Lichtenberg, Mads, Jakobsen, Tim Holm, Kühl, Michael, Kolpen, Mette, Jensen, Peter Østrup & Bjarnsholt, Thomas, 2022, In: FEMS Microbiology Reviews. 46, 5, 13 p., fuac018.Research output: Contribution to journal › Journal article › Research › peer-review
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Line, L., Alhede, M., Kolpen, Mette, Kühl, Michael, Ciofu, Oana, Bjarnsholt, Thomas, Moser, Claus Ernst, Toyofuku, M., Nomura, N., Høiby, Niels & Jensen, Peter Østrup, 2014, In: Frontiers in Microbiology. 5, 11 p., 554.Research output: Contribution to journal › Journal article › Research › peer-review
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Interspecific bacterial interactions are reflected in multispecies biofilm spatial organization
Liu, W., Røder, Henriette Lyng, Madsen, Jonas Stenløkke, Bjarnsholt, Thomas, Sørensen, Søren Johannes & Burmølle, Mette, 2016, In: Frontiers in Microbiology. 7, 8 p., 1366.Research output: Contribution to journal › Review › Research › peer-review
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The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data
Malone, M., Bjarnsholt, Thomas, McBain, A. J., James, G. A., Stoodley, P., Leaper, D., Tachi, M., Schultz, G., Swanson, T. & Wolcott, R. D., Jan 2017, In: Journal of Wound Care. 26, 1, p. 20-25Research output: Contribution to journal › Review › Research › peer-review
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Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy
Malone, M., Fritz, Blaine Gabriel, Vickery, K., Schwarzer, S., Sharma, V., Biggs, N., Radzieta, M., Jeffries, T. T., Dickson, H. G., Jensen, S. O. & Bjarnsholt, Thomas, 2019, In: APMIS. 127, 10, p. 660-670 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Shaping the growth behaviour of biofilms initiated from bacterial aggregates
Melaugh, G., Hutchison, J., Kragh, K. N., Irie, Y., Roberts, A., Bjarnsholt, Thomas, Diggle, S. P., Gordon, V. D. & Allen, R. J., 2 Mar 2016, In: P L o S One. 11, 3, 18 p., e0149683.Research output: Contribution to journal › Journal article › Research › peer-review
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In silico analyses of metagenomes from human atherosclerotic plaque samples
Mitra, S., Drautz-Moses, D. I., Alhede, M., Maw, M. T., Liu, Y., Purbojati, R. W., Yap, Z. H., Kushwaha, K. K., Gheorghe, Alexandra Gabriella, Bjarnsholt, Thomas, Hansen, G. M., Sillesen, Henrik, Hougen, H. P., Hansen, Peter Riis, Yang, L., Tolker-Nielsen, Tim, Schuster, S. C. & Givskov, Michael, 2015, In: Microbiome. 3, p. 1-14 38.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis
Moser, C., Gennip, M. V., Bjarnsholt, Thomas, Jensen, Peter Østrup, Lee, B., Hougen, H. P., Calum, H., Ciofu, Oana, Givskov, Michael, Molin, S. & Høiby, Niels, 1 Feb 2009, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 2, p. 95-107 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 9755066
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Physiological levels of nitrate support anoxic growth by denitrification of Pseudomonas aeruginosa at growth rates reported in cystic fibrosis lungs and sputum
Research output: Contribution to journal › Journal article › Research › peer-review
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2838
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Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes
Research output: Contribution to journal › Journal article › Research › peer-review
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Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Research output: Contribution to journal › Journal article › Research › peer-review
Published